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thymidine and Cancer of Rectum

thymidine has been researched along with Cancer of Rectum in 39 studies

Research Excerpts

ExcerptRelevanceReference
"Twenty-eight patients with advanced adenocarcinoma were treated with a combination of thymidine, 5-FU, and PALA."3.67Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination. ( Bedikian, A; Bodey, GP; Chiuten, DF; Freireich, EJ; Valdivieso, M, 1985)
"Tritiated thymidine incorporation by peripheral human lymphocytes stimulated with phytohemagglutinin (PHA) was investigated in 18 colorectal carcinoma patients (seven with localized tumor and 11 with metastatic tumors)."3.65Phytohemagglutinin-stimulated immune response. Assay in colorectal carcinoma patients. ( Kaplan, MS; Kummerfeld, KB; Lundak, RL; Mino, FO, 1975)
" A model established on the gene dosage effect, which likely results of these chromosome imbalances, may be proposed: (1) increase of thymidine kinase activity (chromosome 17q) and thus of the salvage pathway of thymidine synthesis (2) decrease of thymidine de novo pathways by decreased of thymidylate synthase (chromosome 18) and of dihydrofolate reductase (chromosome 5q) and thus accumulation of 2'-deoxyuridine-5'-P, which saves 2'-deoxycytidine 5'-P (3) decrease of cytidylate (or uridylate) kinase (chromosome 1p) and thus accumulation of 2-deoxycytidine-5-PP and of uridine-5-P (UMP) decreasing the metabolisation of orotidine-5'-P, precursor of 2-deoxycytidine-5-PP, which (4) saves -D-5-ribosyl-PP (PRPP) or even conversion of orotidine-5'-P in PRPP."2.37Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma. ( Dutrillaux, B; Muleris, M, 1986)
"We have compared the ability of cancer tissue to proliferate in native-state culture to the stage and histological grade of four major types of human carcinomas: breast, ovarian, colon, and lung."1.28Cancer biology for individualized therapy: correlation of growth fraction index in native-state histoculture with tumor grade and stage. ( Bordin, GM; Connors, KM; Hoffman, RM; Robb, JA; Umbreit, JN; Vescio, RA; Youngkin, T, 1990)
"In HCT 116 cells, a human colon cancer cell line, the levels of thymidine (0."1.27Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole. ( Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK, 1987)
" In pharmacokinetic studies in five patients, both schedules produced prolonged plasma beta-half-lives of 5-FU (96-189 minutes)."1.27Phase I evaluation and pharmacokinetic study of weekly iv thymidine and 5-FU in patients with advanced colorectal carcinoma. ( Chun, H; Kemeny, N; Lynch, G; Martin, D; Young, C, 1985)
"Screening for colon cancer is discussed with a selective diagnostic approach and with emphasis on this approach in early diagnosis of asymptomatic high risk patients."1.26Efforts in cancer diagnosis: national task forces--large bowel cancer. ( Copeland, MM, 1976)
"Prolifirative activity of rectum cancer cells was investigated with the help of 3H-thymidine in 13 patents before and after radiotherapy in doses 2000-4000 rad."1.26[Autoradiographic study of cancer of the rectum before and after radiotherapy]. ( Gapaniuk, ON; Zagrebin, VM, 1976)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-199035 (89.74)18.7374
1990's4 (10.26)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
DESCHNER, E1
LEWIS, CM1
LIPKIN, M3
Au, JL1
Rustum, YM2
Ledesma, EJ1
Mittelman, A2
Creaven, PJ1
Trotter, GA2
Morgan, GR2
Goeting, N1
Cooper, AJ2
Taylor, I2
Sternberg, A1
Petrelli, NJ1
Au, J1
Rustum, Y1
Creaven, P1
O'Connell, MJ1
Moertel, CG2
Rubin, J1
Hahn, RG1
Kvols, LK1
Schutt, AJ1
Bleiberg, H3
Buyse, M1
van den Heule, B1
Galand, P3
Morret, M1
Alberts, DS1
Einspahr, J1
Ritenbaugh, C1
Aickin, M1
Rees-McGee, S1
Atwood, J1
Emerson, S1
Mason-Liddil, N1
Bettinger, L1
Patel, J1
Bellapravalu, S1
Ramanujam, PS1
Phelps, J1
Clark, L1
Vogel, SJ1
Presant, CA1
Ratkin, GA1
Klahr, C1
Maskens, AP1
Deschner, EE2
Lesher, S1
Schiffer, LM1
Phanse, M1
Copeland, MM1
Zagrebin, VM1
Gapaniuk, ON1
Kaplan, MS1
Mino, FO1
Kummerfeld, KB1
Lundak, RL1
Scalmati, A1
Vescio, RA1
Connors, KM1
Youngkin, T1
Bordin, GM1
Robb, JA1
Umbreit, JN1
Hoffman, RM1
Dutrillaux, B1
Muleris, M1
Pero, RW1
Heim, S1
Bryngelsson, C1
Buroker, TR1
Fleming, TR1
Everson, LK1
Cullinan, SA1
Krook, JE1
Mailliard, JA1
Marschke, RF1
Klaassen, DJ1
Laurie, JA1
Fermor, B1
Umpleby, HC1
Lever, JV1
Symes, MO1
Williamson, RC1
Van Mouwerik, TJ1
Pangallo, CA1
Willson, JK1
Fischer, PH1
Lynch, G1
Kemeny, N1
Chun, H1
Martin, D1
Young, C1
Kirkham, N1
Whitehouse, JM1
Ota, DM1
Drewinko, B1
Lynch, HT1
Schuelke, GS1
Kimberling, WJ1
Albano, WA1
Lynch, JF1
Biscone, KA1
Lipkin, ML1
Mikol, YB1
Sandberg, AA1
Chiuten, DF1
Valdivieso, M1
Bedikian, A1
Bodey, GP1
Freireich, EJ1
Ansfield, FJ1
Ramirez, G1
Watkins, E2
Ogata, Y1
Anderson, LL1
Waters, MF1
Peckham, MJ1
Lauder, I1
Bone, G1
Manousos, ON1
Economidou, J1
Pathouli, C1
Merikas, G1
Mainguet, P1
Mizuno, NS1
Humphrey, EW1
Rowe-Jones, DC1
McKinna, JA2
Knock, FE1
Galt, RM1
Oester, YT1
Renaud, OV1
Sylvester, R1

Reviews

3 reviews available for thymidine and Cancer of Rectum

ArticleYear
Intermediate biomarkers of increased risk for colorectal cancer: comparison of different methods of analysis and modifications by chemopreventive interventions.
    Journal of cellular biochemistry. Supplement, 1992, Volume: 16G

    Topics: Anticarcinogenic Agents; Biomarkers; Biomarkers, Tumor; Cell Cycle; Cell Division; Colonic Neoplasms

1992
Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma.
    Annales de genetique, 1986, Volume: 29, Issue:1

    Topics: Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, 1-3; Chromosomes, Human, 16-18; Chr

1986
Obstacles to the improvement of radiotherapy of rectal cancer.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:12

    Topics: Adenocarcinoma; Animals; Cyclophosphamide; Fluorouracil; Humans; Laparotomy; Lymphography; Methods;

1973

Trials

3 trials available for thymidine and Cancer of Rectum

ArticleYear
The effect of wheat bran fiber and calcium supplementation on rectal mucosal proliferation rates in patients with resected adenomatous colorectal polyps.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 1997, Volume: 6, Issue:3

    Topics: Adenomatous Polyps; Aged; Calcium Carbonate; Calcium, Dietary; Cell Division; Cells, Cultured; Colon

1997
Phase I study of thymidine plus 5-fluorouracil infusions in advanced colorectal carcinoma.
    Cancer treatment reports, 1979, Volume: 63, Issue:1

    Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Flu

1979
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:12

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluat

1985

Other Studies

33 other studies available for thymidine and Cancer of Rectum

ArticleYear
IN VITRO STUDY OF HUMAN RECTAL EPITHELIAL CELLS. I. ATYPICAL ZONE OF H3 THYMIDINE INCORPORATION IN MUCOSA OF MULTIPLE POLYPOSIS.
    The Journal of clinical investigation, 1963, Volume: 42

    Topics: Cell Division; DNA; DNA, Neoplasm; Epithelial Cells; Epithelium; Humans; In Vitro Techniques; Metabo

1963
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
    Cancer research, 1982, Volume: 42, Issue:7

    Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenter

1982
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
    The British journal of surgery, 1984, Volume: 71, Issue:12

    Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine

1984
A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma.
    Cancer chemotherapy and pharmacology, 1984, Volume: 13, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Colonic Neoplasms; Drug Sy

1984
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasm

1984
Cell cycle parameters and prognosis of colorectal cancer.
    European journal of cancer & clinical oncology, 1984, Volume: 20, Issue:3

    Topics: Aged; Colonic Neoplasms; Female; Humans; Interphase; Male; Middle Aged; Mitosis; Prognosis; Rectal N

1984
Correlation between [3H]thymidine and proliferating cell nuclear antigen (PCNA)/cyclin indices in archival, formaldehyde-fixed human colorectal tissues.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:3

    Topics: Adenocarcinoma; Antigens, Neoplasm; Colonic Neoplasms; Humans; Immunohistochemistry; In Vitro Techni

1993
Tritiated thymidine incorporation into epithelial cells of normal-appearing colorectal mucosa of cancer patients.
    Journal of the National Cancer Institute, 1977, Volume: 58, Issue:5

    Topics: Adult; Aged; Cell Division; Colon; Colonic Neoplasms; DNA; Epithelial Cells; Epithelium; Female; Hum

1977
Human colonic tumor cell kinetics: potential for therapy.
    Cancer, 1977, Volume: 40, Issue:5 Suppl

    Topics: Adenocarcinoma; Adenoma; Cell Cycle; Cells, Cultured; Colonic Neoplasms; DNA; DNA-Directed DNA Polym

1977
Efforts in cancer diagnosis: national task forces--large bowel cancer.
    Journal of surgical oncology, 1976, Volume: 8, Issue:6

    Topics: Adult; Antilymphocyte Serum; Bile Acids and Salts; Carcinoembryonic Antigen; Chondro-4-Sulfatase; Co

1976
[Autoradiographic study of cancer of the rectum before and after radiotherapy].
    Arkhiv patologii, 1976, Volume: 38, Issue:9

    Topics: Adenocarcinoma; Aged; Autoradiography; Cell Division; Female; Humans; Isotope Labeling; Male; Middle

1976
Phytohemagglutinin-stimulated immune response. Assay in colorectal carcinoma patients.
    Archives of surgery (Chicago, Ill. : 1960), 1975, Volume: 110, Issue:10

    Topics: Adult; Aged; Carcinoma; Colonic Neoplasms; Humans; Immunity, Cellular; Lectins; Lymphocytes; Middle

1975
Cancer biology for individualized therapy: correlation of growth fraction index in native-state histoculture with tumor grade and stage.
    Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:2

    Topics: Carcinoma, Non-Small-Cell Lung; Cell Division; Colonic Neoplasms; DNA Replication; Female; Humans; L

1990
Lower rates of thymidine incorporation into DNA of skin fibroblasts from patients with adenomatosis of the colon and rectum.
    Carcinogenesis, 1986, Volume: 7, Issue:4

    Topics: Acetoxyacetylaminofluorene; Adult; Child; Colonic Neoplasms; DNA; Female; Fibroblasts; Humans; Male;

1986
Proliferative and metastatic potential of exfoliated colorectal cancer cells.
    Journal of the National Cancer Institute, 1986, Volume: 76, Issue:2

    Topics: Animals; Autoradiography; Cell Division; Colonic Neoplasms; Female; Humans; Lung Neoplasms; Mice; Mi

1986
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
    Biochemical pharmacology, 1987, Mar-15, Volume: 36, Issue:6

    Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxant

1987
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1985, Volume: 4, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Ki

1985
Phase I evaluation and pharmacokinetic study of weekly iv thymidine and 5-FU in patients with advanced colorectal carcinoma.
    Cancer treatment reports, 1985, Volume: 69, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration

1985
Cell kinetics and in vitro clonogenicity of primary colorectal cancer: clinicopathological relationships and the implications for chemotherapy.
    Gut, 1985, Volume: 26, Issue:3

    Topics: Adenocarcinoma; Cells, Cultured; Clone Cells; Colonic Neoplasms; Humans; Kinetics; Neoplasm Staging;

1985
Growth kinetics of human colorectal carcinoma.
    Cancer research, 1985, Volume: 45, Issue:5

    Topics: Adenocarcinoma; Colonic Neoplasms; Humans; Kinetics; Rectal Neoplasms; Thymidine; Tritium

1985
Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies.
    Cancer, 1985, Aug-15, Volume: 56, Issue:4

    Topics: Colon; Colonic Neoplasms; Cytogenetics; Fibroblasts; Genetic Carrier Screening; Genetic Linkage; Gen

1985
Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination.
    Cancer treatment reports, 1985, Volume: 69, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic

1985
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
    Cancer chemotherapy reports, 1971, Volume: 55, Issue:2

    Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridin

1971
Activation of host lymphocytes cultured with cancer cells treated with neuraminidase.
    Nature: New biology, 1971, May-19, Volume: 231, Issue:20

    Topics: Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Culture Tec

1971
Lymphocyte transformation in large bowel cancer.
    British journal of cancer, 1973, Volume: 27, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Carbon Isotopes; Colonic Neoplasms; Hemolysis; Humans; Intestinal Neopl

1973
Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum.
    Gut, 1973, Volume: 14, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Autoradiography; Colonic Neoplasms; DNA; Female; Humans; Immunity, Cell

1973
Cell renewal in familial polyposis: comparison between polyps and adjacent healthy mucosa.
    Gastroenterology, 1972, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Autoradiography; Biopsy; Cell Division; DNA, Neoplasm; Female; Humans; Intestinal

1972
Metabolism of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388) in human and animal tumor tissue.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:4

    Topics: Amides; Animals; Antineoplastic Agents; Carbohydrates; Carbon Isotopes; Chromatography, Thin Layer;

1972
Cytotoxic penetration and concentration in human malignant tumours.
    The British journal of surgery, 1969, Volume: 56, Issue:10

    Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Female; Fluorouracil; Humans; Injections

1969
Cell proliferation in gastrointestinal disease.
    National Cancer Institute monograph, 1969, Volume: 30

    Topics: Atrophy; Autoradiography; Biopsy; Cell Division; DNA; DNA, Neoplasm; Epithelial Cells; Epithelium; F

1969
A physiological study of isolated human tumours.
    Annals of the Royal College of Surgeons of England, 1970, Volume: 46, Issue:2

    Topics: Adenocarcinoma; Adhesiveness; Autoradiography; Colonic Neoplasms; DNA, Neoplasm; Humans; Intestinal

1970
Access of drugs to tumours of the large intestine.
    Proceedings of the Royal Society of Medicine, 1970, Volume: 63 Suppl

    Topics: Autoradiography; Colonic Neoplasms; Humans; Mustard Compounds; Perfusion; Rectal Neoplasms; Sulfur I

1970
The use of selected sulfhydryl inhibitors in a preferential drug attack on cancer.
    Surgery, gynecology & obstetrics, 1971, Volume: 133, Issue:3

    Topics: Adenocarcinoma; Adult; Agar; Animals; Antineoplastic Agents; Anus Neoplasms; Breast Neoplasms; Carci

1971