thymidine has been researched along with Cancer of Rectum in 39 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-eight patients with advanced adenocarcinoma were treated with a combination of thymidine, 5-FU, and PALA." | 3.67 | Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination. ( Bedikian, A; Bodey, GP; Chiuten, DF; Freireich, EJ; Valdivieso, M, 1985) |
| "Tritiated thymidine incorporation by peripheral human lymphocytes stimulated with phytohemagglutinin (PHA) was investigated in 18 colorectal carcinoma patients (seven with localized tumor and 11 with metastatic tumors)." | 3.65 | Phytohemagglutinin-stimulated immune response. Assay in colorectal carcinoma patients. ( Kaplan, MS; Kummerfeld, KB; Lundak, RL; Mino, FO, 1975) |
| " A model established on the gene dosage effect, which likely results of these chromosome imbalances, may be proposed: (1) increase of thymidine kinase activity (chromosome 17q) and thus of the salvage pathway of thymidine synthesis (2) decrease of thymidine de novo pathways by decreased of thymidylate synthase (chromosome 18) and of dihydrofolate reductase (chromosome 5q) and thus accumulation of 2'-deoxyuridine-5'-P, which saves 2'-deoxycytidine 5'-P (3) decrease of cytidylate (or uridylate) kinase (chromosome 1p) and thus accumulation of 2-deoxycytidine-5-PP and of uridine-5-P (UMP) decreasing the metabolisation of orotidine-5'-P, precursor of 2-deoxycytidine-5-PP, which (4) saves -D-5-ribosyl-PP (PRPP) or even conversion of orotidine-5'-P in PRPP." | 2.37 | Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma. ( Dutrillaux, B; Muleris, M, 1986) |
| "We have compared the ability of cancer tissue to proliferate in native-state culture to the stage and histological grade of four major types of human carcinomas: breast, ovarian, colon, and lung." | 1.28 | Cancer biology for individualized therapy: correlation of growth fraction index in native-state histoculture with tumor grade and stage. ( Bordin, GM; Connors, KM; Hoffman, RM; Robb, JA; Umbreit, JN; Vescio, RA; Youngkin, T, 1990) |
| "In HCT 116 cells, a human colon cancer cell line, the levels of thymidine (0." | 1.27 | Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole. ( Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK, 1987) |
| " In pharmacokinetic studies in five patients, both schedules produced prolonged plasma beta-half-lives of 5-FU (96-189 minutes)." | 1.27 | Phase I evaluation and pharmacokinetic study of weekly iv thymidine and 5-FU in patients with advanced colorectal carcinoma. ( Chun, H; Kemeny, N; Lynch, G; Martin, D; Young, C, 1985) |
| "Screening for colon cancer is discussed with a selective diagnostic approach and with emphasis on this approach in early diagnosis of asymptomatic high risk patients." | 1.26 | Efforts in cancer diagnosis: national task forces--large bowel cancer. ( Copeland, MM, 1976) |
| "Prolifirative activity of rectum cancer cells was investigated with the help of 3H-thymidine in 13 patents before and after radiotherapy in doses 2000-4000 rad." | 1.26 | [Autoradiographic study of cancer of the rectum before and after radiotherapy]. ( Gapaniuk, ON; Zagrebin, VM, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (89.74) | 18.7374 |
| 1990's | 4 (10.26) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DESCHNER, E | 1 |
| LEWIS, CM | 1 |
| LIPKIN, M | 3 |
| Au, JL | 1 |
| Rustum, YM | 2 |
| Ledesma, EJ | 1 |
| Mittelman, A | 2 |
| Creaven, PJ | 1 |
| Trotter, GA | 2 |
| Morgan, GR | 2 |
| Goeting, N | 1 |
| Cooper, AJ | 2 |
| Taylor, I | 2 |
| Sternberg, A | 1 |
| Petrelli, NJ | 1 |
| Au, J | 1 |
| Rustum, Y | 1 |
| Creaven, P | 1 |
| O'Connell, MJ | 1 |
| Moertel, CG | 2 |
| Rubin, J | 1 |
| Hahn, RG | 1 |
| Kvols, LK | 1 |
| Schutt, AJ | 1 |
| Bleiberg, H | 3 |
| Buyse, M | 1 |
| van den Heule, B | 1 |
| Galand, P | 3 |
| Morret, M | 1 |
| Alberts, DS | 1 |
| Einspahr, J | 1 |
| Ritenbaugh, C | 1 |
| Aickin, M | 1 |
| Rees-McGee, S | 1 |
| Atwood, J | 1 |
| Emerson, S | 1 |
| Mason-Liddil, N | 1 |
| Bettinger, L | 1 |
| Patel, J | 1 |
| Bellapravalu, S | 1 |
| Ramanujam, PS | 1 |
| Phelps, J | 1 |
| Clark, L | 1 |
| Vogel, SJ | 1 |
| Presant, CA | 1 |
| Ratkin, GA | 1 |
| Klahr, C | 1 |
| Maskens, AP | 1 |
| Deschner, EE | 2 |
| Lesher, S | 1 |
| Schiffer, LM | 1 |
| Phanse, M | 1 |
| Copeland, MM | 1 |
| Zagrebin, VM | 1 |
| Gapaniuk, ON | 1 |
| Kaplan, MS | 1 |
| Mino, FO | 1 |
| Kummerfeld, KB | 1 |
| Lundak, RL | 1 |
| Scalmati, A | 1 |
| Vescio, RA | 1 |
| Connors, KM | 1 |
| Youngkin, T | 1 |
| Bordin, GM | 1 |
| Robb, JA | 1 |
| Umbreit, JN | 1 |
| Hoffman, RM | 1 |
| Dutrillaux, B | 1 |
| Muleris, M | 1 |
| Pero, RW | 1 |
| Heim, S | 1 |
| Bryngelsson, C | 1 |
| Buroker, TR | 1 |
| Fleming, TR | 1 |
| Everson, LK | 1 |
| Cullinan, SA | 1 |
| Krook, JE | 1 |
| Mailliard, JA | 1 |
| Marschke, RF | 1 |
| Klaassen, DJ | 1 |
| Laurie, JA | 1 |
| Fermor, B | 1 |
| Umpleby, HC | 1 |
| Lever, JV | 1 |
| Symes, MO | 1 |
| Williamson, RC | 1 |
| Van Mouwerik, TJ | 1 |
| Pangallo, CA | 1 |
| Willson, JK | 1 |
| Fischer, PH | 1 |
| Lynch, G | 1 |
| Kemeny, N | 1 |
| Chun, H | 1 |
| Martin, D | 1 |
| Young, C | 1 |
| Kirkham, N | 1 |
| Whitehouse, JM | 1 |
| Ota, DM | 1 |
| Drewinko, B | 1 |
| Lynch, HT | 1 |
| Schuelke, GS | 1 |
| Kimberling, WJ | 1 |
| Albano, WA | 1 |
| Lynch, JF | 1 |
| Biscone, KA | 1 |
| Lipkin, ML | 1 |
| Mikol, YB | 1 |
| Sandberg, AA | 1 |
| Chiuten, DF | 1 |
| Valdivieso, M | 1 |
| Bedikian, A | 1 |
| Bodey, GP | 1 |
| Freireich, EJ | 1 |
| Ansfield, FJ | 1 |
| Ramirez, G | 1 |
| Watkins, E | 2 |
| Ogata, Y | 1 |
| Anderson, LL | 1 |
| Waters, MF | 1 |
| Peckham, MJ | 1 |
| Lauder, I | 1 |
| Bone, G | 1 |
| Manousos, ON | 1 |
| Economidou, J | 1 |
| Pathouli, C | 1 |
| Merikas, G | 1 |
| Mainguet, P | 1 |
| Mizuno, NS | 1 |
| Humphrey, EW | 1 |
| Rowe-Jones, DC | 1 |
| McKinna, JA | 2 |
| Knock, FE | 1 |
| Galt, RM | 1 |
| Oester, YT | 1 |
| Renaud, OV | 1 |
| Sylvester, R | 1 |
3 reviews available for thymidine and Cancer of Rectum
| Article | Year |
|---|---|
Intermediate biomarkers of increased risk for colorectal cancer: comparison of different methods of analysis and modifications by chemopreventive interventions.
Topics: Anticarcinogenic Agents; Biomarkers; Biomarkers, Tumor; Cell Cycle; Cell Division; Colonic Neoplasms | 1992 |
Induction of increased salvage pathways of nucleotide synthesis by dosage effect due to chromosome imbalances may be fundamental in carcinogenesis: the example of colorectal carcinoma.
Topics: Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, 1-3; Chromosomes, Human, 16-18; Chr | 1986 |
Obstacles to the improvement of radiotherapy of rectal cancer.
Topics: Adenocarcinoma; Animals; Cyclophosphamide; Fluorouracil; Humans; Laparotomy; Lymphography; Methods; | 1973 |
3 trials available for thymidine and Cancer of Rectum
| Article | Year |
|---|---|
The effect of wheat bran fiber and calcium supplementation on rectal mucosal proliferation rates in patients with resected adenomatous colorectal polyps.
Topics: Adenomatous Polyps; Aged; Calcium Carbonate; Calcium, Dietary; Cell Division; Cells, Cultured; Colon | 1997 |
Phase I study of thymidine plus 5-fluorouracil infusions in advanced colorectal carcinoma.
Topics: Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Flu | 1979 |
A controlled evaluation of recent approaches to biochemical modulation or enhancement of 5-fluorouracil therapy in colorectal carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic Neoplasms; Drug Evaluat | 1985 |
33 other studies available for thymidine and Cancer of Rectum
| Article | Year |
|---|---|
IN VITRO STUDY OF HUMAN RECTAL EPITHELIAL CELLS. I. ATYPICAL ZONE OF H3 THYMIDINE INCORPORATION IN MUCOSA OF MULTIPLE POLYPOSIS.
Topics: Cell Division; DNA; DNA, Neoplasm; Epithelial Cells; Epithelium; Humans; In Vitro Techniques; Metabo | 1963 |
Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Topics: Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Humans; Infusions, Parenter | 1982 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine | 1984 |
A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Colonic Neoplasms; Drug Sy | 1984 |
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasm | 1984 |
Cell cycle parameters and prognosis of colorectal cancer.
Topics: Aged; Colonic Neoplasms; Female; Humans; Interphase; Male; Middle Aged; Mitosis; Prognosis; Rectal N | 1984 |
Correlation between [3H]thymidine and proliferating cell nuclear antigen (PCNA)/cyclin indices in archival, formaldehyde-fixed human colorectal tissues.
Topics: Adenocarcinoma; Antigens, Neoplasm; Colonic Neoplasms; Humans; Immunohistochemistry; In Vitro Techni | 1993 |
Tritiated thymidine incorporation into epithelial cells of normal-appearing colorectal mucosa of cancer patients.
Topics: Adult; Aged; Cell Division; Colon; Colonic Neoplasms; DNA; Epithelial Cells; Epithelium; Female; Hum | 1977 |
Human colonic tumor cell kinetics: potential for therapy.
Topics: Adenocarcinoma; Adenoma; Cell Cycle; Cells, Cultured; Colonic Neoplasms; DNA; DNA-Directed DNA Polym | 1977 |
Efforts in cancer diagnosis: national task forces--large bowel cancer.
Topics: Adult; Antilymphocyte Serum; Bile Acids and Salts; Carcinoembryonic Antigen; Chondro-4-Sulfatase; Co | 1976 |
[Autoradiographic study of cancer of the rectum before and after radiotherapy].
Topics: Adenocarcinoma; Aged; Autoradiography; Cell Division; Female; Humans; Isotope Labeling; Male; Middle | 1976 |
Phytohemagglutinin-stimulated immune response. Assay in colorectal carcinoma patients.
Topics: Adult; Aged; Carcinoma; Colonic Neoplasms; Humans; Immunity, Cellular; Lectins; Lymphocytes; Middle | 1975 |
Cancer biology for individualized therapy: correlation of growth fraction index in native-state histoculture with tumor grade and stage.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Division; Colonic Neoplasms; DNA Replication; Female; Humans; L | 1990 |
Lower rates of thymidine incorporation into DNA of skin fibroblasts from patients with adenomatosis of the colon and rectum.
Topics: Acetoxyacetylaminofluorene; Adult; Child; Colonic Neoplasms; DNA; Female; Fibroblasts; Humans; Male; | 1986 |
Proliferative and metastatic potential of exfoliated colorectal cancer cells.
Topics: Animals; Autoradiography; Cell Division; Colonic Neoplasms; Female; Humans; Lung Neoplasms; Mice; Mi | 1986 |
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxant | 1987 |
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Fluorouracil; Humans; Ki | 1985 |
Phase I evaluation and pharmacokinetic study of weekly iv thymidine and 5-FU in patients with advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration | 1985 |
Cell kinetics and in vitro clonogenicity of primary colorectal cancer: clinicopathological relationships and the implications for chemotherapy.
Topics: Adenocarcinoma; Cells, Cultured; Clone Cells; Colonic Neoplasms; Humans; Kinetics; Neoplasm Staging; | 1985 |
Growth kinetics of human colorectal carcinoma.
Topics: Adenocarcinoma; Colonic Neoplasms; Humans; Kinetics; Rectal Neoplasms; Thymidine; Tritium | 1985 |
Hereditary nonpolyposis colorectal cancer (Lynch syndromes I and II). II. Biomarker studies.
Topics: Colon; Colonic Neoplasms; Cytogenetics; Fibroblasts; Genetic Carrier Screening; Genetic Linkage; Gen | 1985 |
Phase I-II clinical trial of thymidine, 5-FU, and PALA given in combination.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colonic | 1985 |
Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520).
Topics: Blood Cell Count; Bone Marrow; Breast Neoplasms; Colonic Neoplasms; Deoxyuridine; Female; Floxuridin | 1971 |
Activation of host lymphocytes cultured with cancer cells treated with neuraminidase.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Culture Tec | 1971 |
Lymphocyte transformation in large bowel cancer.
Topics: Adenocarcinoma; Adult; Aged; Carbon Isotopes; Colonic Neoplasms; Hemolysis; Humans; Intestinal Neopl | 1973 |
Disturbance of cell-mediated immunity in patients with carcinoma of colon and rectum.
Topics: Adenocarcinoma; Adult; Aged; Autoradiography; Colonic Neoplasms; DNA; Female; Humans; Immunity, Cell | 1973 |
Cell renewal in familial polyposis: comparison between polyps and adjacent healthy mucosa.
Topics: Adolescent; Adult; Autoradiography; Biopsy; Cell Division; DNA, Neoplasm; Female; Humans; Intestinal | 1972 |
Metabolism of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388) in human and animal tumor tissue.
Topics: Amides; Animals; Antineoplastic Agents; Carbohydrates; Carbon Isotopes; Chromatography, Thin Layer; | 1972 |
Cytotoxic penetration and concentration in human malignant tumours.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Female; Fluorouracil; Humans; Injections | 1969 |
Cell proliferation in gastrointestinal disease.
Topics: Atrophy; Autoradiography; Biopsy; Cell Division; DNA; DNA, Neoplasm; Epithelial Cells; Epithelium; F | 1969 |
A physiological study of isolated human tumours.
Topics: Adenocarcinoma; Adhesiveness; Autoradiography; Colonic Neoplasms; DNA, Neoplasm; Humans; Intestinal | 1970 |
Access of drugs to tumours of the large intestine.
Topics: Autoradiography; Colonic Neoplasms; Humans; Mustard Compounds; Perfusion; Rectal Neoplasms; Sulfur I | 1970 |
The use of selected sulfhydryl inhibitors in a preferential drug attack on cancer.
Topics: Adenocarcinoma; Adult; Agar; Animals; Antineoplastic Agents; Anus Neoplasms; Breast Neoplasms; Carci | 1971 |