thymidine has been researched along with Bone Cancer in 42 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test a novel strategy for overcoming intrinsic resistance to methotrexate (MTX) in osteosarcoma (OS) due to nucleoside and nucleobase salvage (NS)." | 7.71 | Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs. ( Cole, PD; Kamen, BA; Smith, AK, 2002) |
| "We recently reported that picomolar doses of norethindrone (NET), a synthetic analog of 19-nortestosterone, significantly stimulated human TE85 osteosarcoma cell proliferation, differentiation, and activity in vitro." | 7.69 | Pretreatment with low doses of norethindrone potentiates the osteogenic effects of fluoride on human osteosarcoma cells. ( Baylink, DJ; Lau, KH; Takada, J, 1995) |
| "Hypoxanthine:guanine phosphoribosyltransferase (HPRT) activity was measured in 14 human osteosarcomas to test whether a subset of these tumors was deficient in the purine salvage pathway enzyme and thus provide a rationale for therapy with methotrexate-thymidine rescue." | 7.67 | Hypoxanthine:guanine phosphoribosyltransferase activity in primary human osteosarcomas. A rationale for therapy with methotrexate-thymidine rescue? ( Houghton, JA; Houghton, PJ; Meyer, WH, 1987) |
| "To test a novel strategy for overcoming intrinsic resistance to methotrexate (MTX) in osteosarcoma (OS) due to nucleoside and nucleobase salvage (NS)." | 3.71 | Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs. ( Cole, PD; Kamen, BA; Smith, AK, 2002) |
| " We used Swarm-rat chondrosarcoma chondrocytes to investigate the effect of each factor individually and of both factors in combination on [(3)H]thymidine incorporation into DNA and on [(35)S]sulfate incorporation into glycosaminoglycans." | 3.70 | Regulation by IGF-I and TGF-beta1 of Swarm-rat chondrosarcoma chondrocytes. ( Li, XQ; Matsumura, T; Trippel, SB; Whelan, MC, 2000) |
| "We recently reported that picomolar doses of norethindrone (NET), a synthetic analog of 19-nortestosterone, significantly stimulated human TE85 osteosarcoma cell proliferation, differentiation, and activity in vitro." | 3.69 | Pretreatment with low doses of norethindrone potentiates the osteogenic effects of fluoride on human osteosarcoma cells. ( Baylink, DJ; Lau, KH; Takada, J, 1995) |
| "The present study was performed to investigate the regulation of cytosolic pH (pHi) and DNA synthesis by parathyroid hormone(PTH) and PTH-related peptide (PTHrP) in osteoblasts, using osteoblastic osteosarcoma cells, UMR-106 which possessed PTH-responsive dual signal transduction systems (cAMP-dependent protein kinase (PKA) and calcium/protein kinase C [Ca/PKC]) and amiloride-inhibitable Na+/H+ exchange system." | 3.68 | Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange. ( Fujita, T; Fukase, M; Kano, J; Sugimoto, T, 1992) |
| "Hypoxanthine:guanine phosphoribosyltransferase (HPRT) activity was measured in 14 human osteosarcomas to test whether a subset of these tumors was deficient in the purine salvage pathway enzyme and thus provide a rationale for therapy with methotrexate-thymidine rescue." | 3.67 | Hypoxanthine:guanine phosphoribosyltransferase activity in primary human osteosarcomas. A rationale for therapy with methotrexate-thymidine rescue? ( Houghton, JA; Houghton, PJ; Meyer, WH, 1987) |
| " Results show that the cell proliferation rate of the stem cells in respective tissues was markedly suppressed, dependent on time after dosing and the dose of 90Y; 3." | 1.32 | Synchronous evaluation of toxico- and pharmaco-dynamics of yttrium-90 by a novel autoradiographic procedure. ( Awazu, S; Debori, Y; Hamai, Y; Hatori, A; Higashi, N; Kawai, N; Kuroiwa, H; Sato, Y; Shigematsu, A; Takeuchi, N; Yamabayashi, H; Yamamoto, T; Yui, J, 2004) |
| "[3H]Thymidine incorporation was used to evaluate cell proliferation." | 1.30 | Correlation between pulsed electromagnetic fields exposure time and cell proliferation increase in human osteosarcoma cell lines and human normal osteoblast cells in vitro. ( Baroni, T; Caruso, A; De Mattei, M; Pezzetti, F; Sollazzo, V; Traina, GC, 1999) |
| "In this model, enhanced bone resorption was associated with the selective growth promotion of metastatic W256 cells in bone, suggesting the existence of a bone-derived factor which is mitogenic to W256 cells." | 1.28 | Stimulation of bone resorption results in a selective increase in the growth rate of spontaneously metastatic Walker 256 cancer cells in bone. ( Kostenuik, PJ; Orr, FW; Singh, G; Suyama, KL, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (38.10) | 18.7374 |
| 1990's | 13 (30.95) | 18.2507 |
| 2000's | 11 (26.19) | 29.6817 |
| 2010's | 2 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cuccurullo, V | 1 |
| Cascini, GL | 1 |
| Tamburrini, O | 1 |
| Rotondo, A | 1 |
| Mansi, L | 1 |
| Wiebe, LI | 1 |
| Sun, W | 1 |
| Zhou, A | 1 |
| Yang, J | 1 |
| Sjuvarsson, EV | 1 |
| Eriksson, S | 1 |
| Paproski, RJ | 1 |
| Cass, CE | 1 |
| Kumar, P | 1 |
| Knaus, EE | 1 |
| Cole, PD | 1 |
| Smith, AK | 1 |
| Kamen, BA | 1 |
| Cohly, HH | 1 |
| Abraham, GE | 1 |
| Ndebele, K | 1 |
| Jenkins, JJ | 1 |
| Thompson, J | 1 |
| Angel, MF | 1 |
| Zheng, X | 1 |
| Lundberg, M | 1 |
| Karlsson, A | 1 |
| Johansson, M | 1 |
| Conover, CA | 1 |
| Khosla, S | 1 |
| Shigematsu, A | 1 |
| Kawai, N | 1 |
| Kuroiwa, H | 1 |
| Higashi, N | 1 |
| Debori, Y | 1 |
| Yui, J | 1 |
| Hamai, Y | 1 |
| Hatori, A | 1 |
| Awazu, S | 1 |
| Takeuchi, N | 1 |
| Yamabayashi, H | 1 |
| Sato, Y | 1 |
| Yamamoto, T | 1 |
| Lafleur, EA | 1 |
| Koshkina, NV | 1 |
| Stewart, J | 1 |
| Jia, SF | 1 |
| Worth, LL | 1 |
| Duan, X | 1 |
| Kleinerman, ES | 1 |
| Sakayama, K | 1 |
| Mashima, N | 1 |
| Kidani, T | 1 |
| Miyazaki, T | 1 |
| Yamamoto, H | 1 |
| Masuno, H | 1 |
| Buck, AK | 1 |
| Herrmann, K | 1 |
| Büschenfelde, CM | 1 |
| Juweid, ME | 1 |
| Bischoff, M | 1 |
| Glatting, G | 1 |
| Weirich, G | 1 |
| Möller, P | 1 |
| Wester, HJ | 1 |
| Scheidhauer, K | 1 |
| Dechow, T | 1 |
| Peschel, C | 1 |
| Schwaiger, M | 1 |
| Reske, SN | 1 |
| Magrassi, B | 1 |
| Pagani, G | 1 |
| Roveta, G | 1 |
| Umeda, T | 1 |
| Matsuoka, O | 1 |
| Wheeler, RH | 1 |
| Clauw, DJ | 1 |
| Natale, RB | 1 |
| Ruddon, RW | 1 |
| Ishii, M | 1 |
| Yamamuro, T | 1 |
| Takeda, T | 1 |
| Banes, AJ | 1 |
| Mechanic, GL | 1 |
| Zhou, Y | 1 |
| Li, J | 1 |
| Xu, K | 1 |
| Hu, SX | 1 |
| Benedict, WF | 1 |
| Xu, HJ | 1 |
| Raile, K | 1 |
| Höflich, A | 1 |
| Kessler, U | 1 |
| Yang, Y | 1 |
| Pfuender, M | 1 |
| Blum, WF | 1 |
| Kolb, H | 1 |
| Schwarz, HP | 1 |
| Kiess, W | 1 |
| Kostenuik, PJ | 3 |
| Orr, FW | 3 |
| Suyama, K | 1 |
| Singh, G | 3 |
| Downes, S | 1 |
| Clifford, CJ | 1 |
| Scotchford, C | 1 |
| Klein, CP | 1 |
| Takada, J | 1 |
| Baylink, DJ | 1 |
| Lau, KH | 2 |
| Haberkorn, U | 1 |
| Oberdorfer, F | 1 |
| Klenner, T | 1 |
| Strauss, LG | 1 |
| Stöhr, M | 1 |
| Wallich, R | 1 |
| Altmann, A | 1 |
| Kaick, GV | 1 |
| Kenny, JS | 1 |
| Kisaalita, WS | 1 |
| Rowland, G | 1 |
| Thai, C | 1 |
| Foutz, T | 1 |
| De Mattei, M | 1 |
| Caruso, A | 1 |
| Traina, GC | 1 |
| Pezzetti, F | 1 |
| Baroni, T | 1 |
| Sollazzo, V | 1 |
| Matsumura, T | 1 |
| Whelan, MC | 1 |
| Li, XQ | 1 |
| Trippel, SB | 1 |
| Girnita, L | 1 |
| Girnita, A | 1 |
| Wang, M | 1 |
| Meis-Kindblom, JM | 1 |
| Kindblom, LG | 1 |
| Larsson, O | 1 |
| Hashimoto, H | 1 |
| Kofránek, V | 1 |
| Parízek, O | 1 |
| Svoboda, V | 1 |
| Bubeníková, D | 1 |
| Machek, J | 1 |
| Frei, E | 1 |
| Balmukhanov, SB | 1 |
| Kozhanova, SV | 1 |
| Smagulova, NA | 1 |
| Kaliev, IuSh | 1 |
| Kosaev, IuSh | 1 |
| Bergsagel, DE | 1 |
| Ogawa, M | 1 |
| Librach, SL | 1 |
| Sugimoto, T | 1 |
| Kano, J | 1 |
| Fukase, M | 1 |
| Fujita, T | 1 |
| Fang, MA | 1 |
| Kujubu, DA | 1 |
| Hahn, TJ | 1 |
| Suyama, KL | 2 |
| Willnow, U | 1 |
| Schmidt, J | 1 |
| Closs, EI | 1 |
| Livne, E | 1 |
| Erfle, V | 1 |
| Silbermann, M | 1 |
| Birek, C | 1 |
| Pawson, T | 1 |
| McCulloch, CA | 1 |
| Tenenbaum, HC | 1 |
| Meyer, WH | 1 |
| Houghton, JA | 1 |
| Houghton, PJ | 1 |
| Terz, JJ | 1 |
| Curutchet, HP | 1 |
| Lawrence, W | 1 |
| Hagemann, RF | 1 |
| Schiffer, LM | 1 |
| Brues, AM | 1 |
| Auerbach, H | 1 |
| DeRoche, GM | 1 |
| Grube, DD | 1 |
2 reviews available for thymidine and Bone Cancer
| Article | Year |
|---|---|
Bone metastases radiopharmaceuticals: an overview.
Topics: 3-Iodobenzylguanidine; Bone Neoplasms; Choline; Dihydroxyphenylalanine; Diphosphonates; Fluorine Rad | 2013 |
Methotrexate revisited.
Topics: Adolescent; Adult; Alkalies; Aminopterin; Animals; Bone Marrow; Bone Neoplasms; Drug Therapy, Combin | 1976 |
2 trials available for thymidine and Bone Cancer
| Article | Year |
|---|---|
Imaging bone and soft tissue tumors with the proliferation marker [18F]fluorodeoxythymidine.
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; | 2008 |
Sequential therapy compared with combination therapy in multiple myeloma.
Topics: Autoradiography; Bence Jones Protein; Bone Neoplasms; Cell Count; Drug Therapy, Combination; Humans; | 1975 |
38 other studies available for thymidine and Bone Cancer
| Article | Year |
|---|---|
Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2).
Topics: Animals; Antineoplastic Agents; Autoradiography; Bone Neoplasms; Cell Line, Tumor; Dose-Response Rel | 2012 |
Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Bone Neoplasms; Cattle; Culture Medi | 2002 |
Effects of static electromagnetic fields on characteristics of MG-63 osteoblasts grown in culture.
Topics: Bone Neoplasms; Cell Division; Electromagnetic Fields; Gene Expression Regulation, Neoplastic; Human | 2003 |
Lipid-mediated protein delivery of suicide nucleoside kinases.
Topics: Animals; Arabinonucleosides; Bone Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; CHO Cells; Criceti | 2003 |
Role of extracellular matrix in insulin-like growth factor (IGF) binding protein-2 regulation of IGF-II action in normal human osteoblasts.
Topics: Animals; Apoptosis; Bone Neoplasms; Breast Neoplasms; Cattle; Cell Division; Cells, Cultured; Collag | 2003 |
Synchronous evaluation of toxico- and pharmaco-dynamics of yttrium-90 by a novel autoradiographic procedure.
Topics: Animals; Area Under Curve; Autoradiography; Bone Marrow; Bone Neoplasms; Cell Line, Tumor; Cell Nucl | 2004 |
Increased Fas expression reduces the metastatic potential of human osteosarcoma cells.
Topics: Animals; Apoptosis; Bone Neoplasms; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Lu | 2004 |
Effect of cortisol on cell proliferation and the expression of lipoprotein lipase and vascular endothelial growth factor in a human osteosarcoma cell line.
Topics: Blotting, Western; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Replication; Hormone An | 2008 |
[Autoradiographic studies with thymidine-H3 in Oberling's aleukemic myeloma in rats, during bone invasion].
Topics: Animals; Autoradiography; Bone Neoplasms; DNA; Neoplasm Metastasis; Plasmacytoma; Rats; Thymidine; T | 1967 |
[Double tracer autoradiography of bone tumor using 3H-thymidine and radionuclides for diagnostic purpose].
Topics: Animals; Autoradiography; Bone Neoplasms; Diphosphonates; Gallium Radioisotopes; Half-Life; Male; Mi | 1982 |
The cytokinetic and cytotoxic effects of ICRF-159 and ICRF-187 in vitro and ICRF-187 in human bone marrow in vivo.
Topics: Antineoplastic Agents; Bone Marrow Cells; Bone Neoplasms; Burkitt Lymphoma; Cell Cycle; Cell Divisio | 1983 |
[Assay of anti-cancer drug sensitivity of cells from human tumors. Detection of cell viability with radioisotope (author's transl)].
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Count; Cell Survival; Cells, Cultured; HeLa Cells; Human | 1982 |
Collagen and noncollagen protein synthesis in chick limb bud cells infected with a virus that causes osteoblastoma.
Topics: Animals; Avian Myeloblastosis Virus; Bone Neoplasms; Cell Adhesion; Cell Division; Cells, Cultured; | 1981 |
Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells.
Topics: Animals; Base Sequence; Bone Neoplasms; Cell Division; Cell Line; DNA Primers; DNA, Neoplasm; Gene E | 1994 |
Human osteosarcoma (U-2 OS) cells express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptors and synthesize IGF-II: autocrine growth stimulation by IGF-II via the IGF-I receptor
Topics: Animals; Binding, Competitive; Blood; Blotting, Northern; Blotting, Western; Bone Neoplasms; Cell Di | 1994 |
Increased growth rate and tumor burden of spontaneously metastatic Walker 256 cancer cells in the skeleton of bisphosphonate-treated rats.
Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Neoplasms; Carcinoma 256, Walker; Cell Division; Dip | 1993 |
Comparison of the release of growth hormone from hydroxyapatite, heat-treated hydroxyapatite, and fluoroapatite coatings on titanium.
Topics: Apatites; Biocompatible Materials; Bone Neoplasms; Cell Division; Ceramics; DNA; Durapatite; Enzyme- | 1995 |
Pretreatment with low doses of norethindrone potentiates the osteogenic effects of fluoride on human osteosarcoma cells.
Topics: Alkaline Phosphatase; Androgens; Bone Neoplasms; Calcitriol; Collagen; Dose-Response Relationship, D | 1995 |
Metabolic and transcriptional changes in osteosarcoma cells treated with chemotherapeutic drugs.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Cisplatin; Deoxyglucose; Flow Cytometry; Fluorodeoxy | 1994 |
Quantitative study of calcium uptake by tumorigenic bone (TE-85) and neuroblastoma x glioma (NG108-15) cells exposed to extremely-low-frequency (ELF) electric fields.
Topics: Animals; Biological Transport; Bone Neoplasms; Calcium; Cattle; Cell Division; DNA, Neoplasm; Electr | 1997 |
Correlation between pulsed electromagnetic fields exposure time and cell proliferation increase in human osteosarcoma cell lines and human normal osteoblast cells in vitro.
Topics: Adult; Bone Neoplasms; Cell Division; Cells, Cultured; Culture Media; Electromagnetic Fields; Humans | 1999 |
Regulation by IGF-I and TGF-beta1 of Swarm-rat chondrosarcoma chondrocytes.
Topics: Animals; Bone Neoplasms; Cell Division; Cells, Cultured; Chondrocytes; Chondrosarcoma; Glycosaminogl | 2000 |
A link between basic fibroblast growth factor (bFGF) and EWS/FLI-1 in Ewing's sarcoma cells.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Bone Neoplasms; Cell Cycle; Cell Division; Chromosomes, Huma | 2000 |
Differential effects of bacterial toxins on mitogenic actions of sodium fluoride and those of aluminum fluoride in human TE85 osteosarcoma cells.
Topics: Alkaline Phosphatase; Aluminum Compounds; Bone Neoplasms; Cell Division; Cholera Toxin; Fluorides; H | 2001 |
3H-TDR labelling of osteoprogenitor cells after 226RA incorporation in mice.
Topics: Animals; Autoradiography; Bone and Bones; Bone Neoplasms; Cell Division; DNA; Dose-Response Relation | 1977 |
[Blast-transformation reaction in patients with bone tumors].
Topics: Bone Neoplasms; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Thymidine | 1976 |
Mouse myeloma. A model for studies of cell kinetics.
Topics: Alkylating Agents; Animals; Bone Marrow; Bone Marrow Cells; Bone Neoplasms; Cell Division; Cells, Cu | 1975 |
Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange.
Topics: Amiloride; Bone Neoplasms; Bucladesine; Calcimycin; Carrier Proteins; DNA, Neoplasm; Dose-Response R | 1992 |
The effects of prostaglandin E2, parathyroid hormone, and epidermal growth factor on mitogenesis, signaling, and primary response genes in UMR 106-01 osteoblast-like cells.
Topics: Animals; Bone Neoplasms; Calcium; Colforsin; Cyclic AMP; Cycloheximide; Dinoprostone; DNA-Binding Pr | 1992 |
Stimulation of bone resorption results in a selective increase in the growth rate of spontaneously metastatic Walker 256 cancer cells in bone.
Topics: Animals; Body Burden; Bone Neoplasms; Bone Resorption; Calcium; Carcinoma 256, Walker; Cell Division | 1992 |
A quantitative model for spontaneous bone metastasis: evidence for a mitogenic effect of bone on Walker 256 cancer cells.
Topics: Animals; Body Burden; Bone and Bones; Bone Neoplasms; Carcinoma 256, Walker; Cell Division; Female; | 1992 |
[Effect by proliferation kinetics of malignant tumors of children of hyperthermia].
Topics: Autoradiography; Bone Neoplasms; Cell Division; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; | 1990 |
Biochemical characterization of a virus-induced osteosarcoma-like osseous lesion in vitro.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Bone Neoplasms; Calcium; Cartilage; Cell Count; Cel | 1989 |
Dexamethasone effects on induction of neoplastic transformation by Fujinami sarcoma virus in an in vitro chick embryo periosteal model for osteosarcoma.
Topics: Alkaline Phosphatase; Animals; Avian Sarcoma Viruses; Bone Neoplasms; Cell Transformation, Neoplasti | 1988 |
Hypoxanthine:guanine phosphoribosyltransferase activity in primary human osteosarcomas. A rationale for therapy with methotrexate-thymidine rescue?
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Female; Humans; Hypoxanthine; | 1987 |
Analysis of the cell kinetics of human solid tumors.
Topics: Adult; Aged; Biopsy; Bone Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Colo | 1971 |
Cell kinetic analysis of a human melanoma in vitro and in vivo-vitro.
Topics: Adult; Bone Marrow; Bone Marrow Cells; Bone Neoplasms; Carbon Isotopes; Culture Techniques; DNA, Neo | 1971 |
Mechanisms of carcinogenesis. ANL-7635.
Topics: Animals; Autoradiography; Bone Neoplasms; Carcinogens; DNA; Dogs; Liver; Mice; Neoplasms, Experiment | 1969 |