thymidine has been researched along with Ataxia Telangiectasia in 19 studies
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of bromodeoxyuridine (BrdU)-substituted DNA template and thymidine (dT) pool on excess sister-chromatid exchanges (SCEs) was studied in Bloom syndrome (BS) cells and an ataxia telangiectasia (AT)-derived mutant cell line (AsHa)." | 7.68 | Bromodeoxyuridine (BrdU) template and thymidine pool effects on high frequencies of sister-chromatid exchange (SCE) in Bloom syndrome cells and a mutant cell line (AsHa) originated from ataxia telangiectasia. ( Li, MJ; Shiraishi, Y, 1990) |
| "The effect of bromodeoxyuridine (BrdU)-substituted DNA template and thymidine (dT) pool on excess sister-chromatid exchanges (SCEs) was studied in Bloom syndrome (BS) cells and an ataxia telangiectasia (AT)-derived mutant cell line (AsHa)." | 3.68 | Bromodeoxyuridine (BrdU) template and thymidine pool effects on high frequencies of sister-chromatid exchange (SCE) in Bloom syndrome cells and a mutant cell line (AsHa) originated from ataxia telangiectasia. ( Li, MJ; Shiraishi, Y, 1990) |
| "X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied." | 1.26 | Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages. ( Meyers, M; Natarajan, AT, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (68.42) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jaspers, NG | 2 |
| Zdzienicka, MZ | 1 |
| Houldsworth, J | 1 |
| Lavin, MF | 1 |
| Li, CY | 1 |
| Nagasawa, H | 1 |
| Dahlberg, WK | 1 |
| Little, JB | 1 |
| Hannan, MA | 1 |
| Khougeer, F | 1 |
| Halees, Z | 1 |
| Sanei, AM | 1 |
| Khan, BA | 1 |
| Yan, M | 1 |
| Qiang, W | 1 |
| Liu, N | 1 |
| Shen, J | 1 |
| Lynn, WS | 1 |
| Wong, PK | 1 |
| Natarajan, AT | 1 |
| Meyers, M | 1 |
| Kenne, K | 1 |
| Akerblom, L | 1 |
| Shiraishi, Y | 1 |
| Li, MJ | 1 |
| Curry, CJ | 1 |
| O'Lague, P | 1 |
| Tsai, J | 1 |
| Hutchison, HT | 1 |
| Wara, D | 1 |
| Gatti, RA | 1 |
| Hutchinson, HT | 1 |
| McFarlin, DE | 1 |
| Oppenheim, JJ | 1 |
| Schiff, RI | 1 |
| Buckley, RH | 1 |
| Gilbertsen, RB | 1 |
| Metzgar, RS | 1 |
| Lawton, AR | 1 |
| Wu, LY | 1 |
| Cooper, MD | 1 |
| Dwyer, JM | 1 |
| Hosking, CS | 2 |
| Griscelli, C | 1 |
| Revillard, JP | 1 |
| Betuel, H | 1 |
| Herzog, C | 1 |
| Touraine, JL | 1 |
| Panush, RS | 1 |
| Bianco, NE | 1 |
| Schur, PH | 1 |
| Rocklin, RE | 1 |
| David, JR | 1 |
| Stillman, JS | 1 |
| Fitzgerald, MG | 2 |
| Simons, MJ | 1 |
| Rigas, DA | 1 |
| Tisdale, VV | 1 |
| Hecht, F | 1 |
| Naspitz, CK | 1 |
| Eisen, AH | 1 |
| Richter, M | 1 |
19 other studies available for thymidine and Ataxia Telangiectasia
| Article | Year |
|---|---|
Inhibition of DNA synthesis by ionizing radiation: a marker for an S-phase checkpoint.
Topics: Animals; Ataxia Telangiectasia; Biomarkers; Cells, Cultured; DNA Replication; Gamma Rays; Humans; Is | 2006 |
Effect of ionizing radiation on synthesis of sub-replicon size DNA in ataxia telangiectasia cells.
Topics: Ataxia Telangiectasia; Cells, Cultured; Centrifugation, Density Gradient; DNA; DNA Replication; Gamm | 1983 |
Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.
Topics: Ataxia Telangiectasia; Base Sequence; Blotting, Western; Cell Cycle; Cell Line; Cell Survival; Cycli | 1995 |
Increased radiosensitivity and radioresistant DNA synthesis in cultured fibroblasts from patients with coronary atherosclerosis.
Topics: Adult; Ataxia Telangiectasia; Cell Survival; Cells, Cultured; Coronary Artery Disease; DNA; Female; | 1994 |
The ataxia-telangiectasia gene product may modulate DNA turnover and control cell fate by regulating cellular redox in lymphocytes.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Ataxia Telangiectasia; Ataxia Telangiectasia Muta | 2001 |
Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages.
Topics: Ataxia Telangiectasia; Cell Cycle; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes, | 1979 |
Deoxyribonucleoside triphosphate pool levels in three cell strains of human chromosome instability syndromes: ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368).
Topics: Anemia, Aplastic; Ataxia Telangiectasia; Bloom Syndrome; Cell Division; Cell Line; Culture Media; De | 1990 |
Bromodeoxyuridine (BrdU) template and thymidine pool effects on high frequencies of sister-chromatid exchange (SCE) in Bloom syndrome cells and a mutant cell line (AsHa) originated from ataxia telangiectasia.
Topics: Ataxia Telangiectasia; Bloom Syndrome; Bromodeoxyuridine; Cell Fusion; Cell Line; Diploidy; Dose-Res | 1990 |
ATFresno: a phenotype linking ataxia-telangiectasia with the Nijmegen breakage syndrome.
Topics: Ataxia Telangiectasia; California; Cell Line; Cells, Cultured; Child; Chromosome Aberrations; Chromo | 1989 |
Impaired lymphocyte transformation in ataxia-telangiectasia in part due to a plasma inhibitory factor.
Topics: Adolescent; Adult; Ataxia Telangiectasia; Child; Child, Preschool; Culture Techniques; Electrophores | 1969 |
Membrane receptors and in vitro responsiveness of lymphocytes in human immunodeficiency.
Topics: Adolescent; Adult; Agammaglobulinemia; Ataxia Telangiectasia; Binding Sites, Antibody; Candida albic | 1974 |
The cellular basis of IgA deficiency in humans.
Topics: Ataxia Telangiectasia; Autoradiography; B-Lymphocytes; Blood Protein Disorders; Carbon Radioisotopes | 1974 |
Antigen-binding lymphocytes in children with immune deficiency.
Topics: Adult; Agammaglobulinemia; Antibodies, Bacterial; Antibody Formation; Antigens, Bacterial; Ataxia Te | 1972 |
Transfer factor therapy in immuno-deficiencies.
Topics: Agammaglobulinemia; Antigens; Ataxia Telangiectasia; Candida; Candidiasis, Cutaneous; Hypersensitivi | 1973 |
Juvenile rheumatoid arthritis. Cellular hypersensitivity and selective IgA deficiency.
Topics: Agammaglobulinemia; Arthritis, Juvenile; Ataxia Telangiectasia; Cell Migration Inhibition; Complemen | 1972 |
Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases.
Topics: Agammaglobulinemia; Ataxia Telangiectasia; Child; Child, Preschool; Culture Techniques; Humans; Immu | 1971 |
Transformation of blood lymphocytes in ataxia telangiectasia. Dose and time response to phytohemagglutinin.
Topics: Ataxia Telangiectasia; Carbon Isotopes; Culture Techniques; Female; Heterozygote; Humans; Lectins; L | 1970 |
The establishment of a normal human population dose-response curve for lymphocytes cultured with PHA (phytohaemagglutinin).
Topics: Adolescent; Adult; Ataxia Telangiectasia; Child; Culture Techniques; DNA; Humans; Immunologic Defici | 1971 |
DN synthesis in vitro in leukocytes from patients with ataxia telangiectasia.
Topics: Ataxia Telangiectasia; Autoradiography; Cell Differentiation; Child; Child, Preschool; Culture Techn | 1968 |