Compounds > thymidine
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thymidine and Adverse Drug Event

thymidine has been researched along with Adverse Drug Event in 12 studies

Research Excerpts

ExcerptRelevanceReference
"In the phase-III GLOBE/015 studies, telbivudine demonstrated superior efficacy vs lamivudine during 2-year treatment in HBeAg-positive and HBeAg-negative chronic hepatitis B (CHB)."9.17Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B. ( Bao, W; Chan, HL; Gane, EJ; Hou, J; Jia, J; Liaw, YF; Naoumov, NV; Niu, J; Papatheodoridis, G; Thongsawat, S; Trylesinski, A; Wan, M; Wang, Y, 2013)
"Telbivudine, an FDA pregnancy category B drug, has been found to reduce hepatitis B virus (HBV) perinatal transmission with no safety concerns in infants aged up to 1 year."7.85Long-term safety and efficacy of telbivudine in infants born to mothers treated during the second or third trimesters of pregnancy. ( Ding, Y; Han, GR; Jiang, HX; Wang, CM; Wang, GJ; Yue, X; Zhao, W; Zhou, L, 2017)
"Both telbivudine and entecavir were associated with eGFR improvement, especially in patients with renal insufficiency."5.40A comparison of efficacy and safety of 2-year telbivudine and entecavir treatment in patients with chronic hepatitis B: a match-control study. ( Chang, KC; Chen, CH; Chiu, KW; Hu, TH; Hung, CH; Lee, CM; Lu, SN; Tsai, MC; Tseng, PL; Wang, JH; Yen, YH, 2014)
"In the phase-III GLOBE/015 studies, telbivudine demonstrated superior efficacy vs lamivudine during 2-year treatment in HBeAg-positive and HBeAg-negative chronic hepatitis B (CHB)."5.17Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B. ( Bao, W; Chan, HL; Gane, EJ; Hou, J; Jia, J; Liaw, YF; Naoumov, NV; Niu, J; Papatheodoridis, G; Thongsawat, S; Trylesinski, A; Wan, M; Wang, Y, 2013)
"Telbivudine, an FDA pregnancy category B drug, has been found to reduce hepatitis B virus (HBV) perinatal transmission with no safety concerns in infants aged up to 1 year."3.85Long-term safety and efficacy of telbivudine in infants born to mothers treated during the second or third trimesters of pregnancy. ( Ding, Y; Han, GR; Jiang, HX; Wang, CM; Wang, GJ; Yue, X; Zhao, W; Zhou, L, 2017)
"Entecavir (ETV) is effective in the treatment of chronic hepatitis B virus (HBV) infections, even in patients with underlying cirrhosis."3.81Efficacy of telbivudine compared with entecavir in hepatitis B virus-related cirrhosis: 2 year follow-up data. ( Byun, KS; Hyun, JJ; Kang, S; Kim, HR; Kim, JH; Kim, SY; Koo, JS; Lee, SW; Seo, YS; Suh, SJ; Um, SH; Yeon, JE; Yim, HJ, 2015)
"Telbivudine was absorbed rapidly and exhibited dose-related plasma exposure."2.72Single-dose and multiple-dose pharmacokinetics and safety of telbivudine after oral administration in healthy Chinese subjects. ( Brown, NA; Chao, GC; Hu, P; Jiang, J; Pietropaolo, K; Wang, H; Zhou, XJ, 2006)
"Both telbivudine and entecavir were associated with eGFR improvement, especially in patients with renal insufficiency."1.40A comparison of efficacy and safety of 2-year telbivudine and entecavir treatment in patients with chronic hepatitis B: a match-control study. ( Chang, KC; Chen, CH; Chiu, KW; Hu, TH; Hung, CH; Lee, CM; Lu, SN; Tsai, MC; Tseng, PL; Wang, JH; Yen, YH, 2014)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's1 (8.33)18.2507
2000's1 (8.33)29.6817
2010's7 (58.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W1
Wang, Y1
Thongsawat, S1
Gane, EJ1
Liaw, YF1
Jia, J1
Hou, J1
Chan, HL1
Papatheodoridis, G1
Wan, M1
Niu, J1
Bao, W1
Trylesinski, A1
Naoumov, NV1
Tsai, MC2
Chen, CH2
Hung, CH2
Lee, CM2
Chiu, KW2
Wang, JH2
Lu, SN2
Tseng, PL2
Chang, KC2
Yen, YH2
Hu, TH2
Kim, HR1
Yim, HJ1
Kang, S1
Suh, SJ1
Kim, SY1
Hyun, JJ1
Koo, JS1
Kim, JH1
Seo, YS1
Yeon, JE1
Lee, SW1
Byun, KS1
Um, SH1
Lin, MT1
Chou, YP1
Yue-Meng, W1
Li, YH1
Wu, HM1
Yang, J1
Xu, Y1
Yang, LH1
Yang, JH1
Han, GR1
Jiang, HX1
Wang, CM1
Ding, Y1
Wang, GJ1
Yue, X1
Zhou, L1
Zhao, W1
Hu, P1
Jiang, J1
Wang, H1
Pietropaolo, K1
Chao, GC1
Brown, NA1
Zhou, XJ1
Marmer, DJ1
Steele, RW1
Miescher, PA1
Nydegger, U1
Ward, JM1
Weghorst, CM1
Diwan, BA1
Konishi, N1
Lubet, RA1
Henneman, JR1
Devor, DE1
Honegger, P1
Werffeli, P1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Study of Efficacy and Safety of Telbivudine in Pregnancy for the Prevention of Perinatal Transmission of Hepatitis B Virus Infection[NCT00939068]Phase 4180 participants (Anticipated)Interventional2008-02-29Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for thymidine and Adverse Drug Event

ArticleYear
[Drug-induced thrombocytopenias].
    Blut, 1976, Volume: 32, Issue:5

    Topics: Agglutination Tests; Autoimmune Diseases; Complement Fixation Tests; Culture Techniques; Drug-Relate

1976
Evaluation of cell proliferation in the kidneys of rodents with bromodeoxyuridine immunohistochemistry of tritiated thymidine autoradiography after exposure to renal toxins, tumor promoters, and carcinogens.
    Progress in clinical and biological research, 1991, Volume: 369

    Topics: Animals; Autoradiography; Bromodeoxyuridine; Carcinogenicity Tests; Carcinogens; Cell Division; Drug

1991

Trials

2 trials available for thymidine and Adverse Drug Event

ArticleYear
Efficacy and safety of continuous 4-year telbivudine treatment in patients with chronic hepatitis B.
    Journal of viral hepatitis, 2013, Volume: 20, Issue:4

    Topics: Adult; Antiviral Agents; Drug-Related Side Effects and Adverse Reactions; Female; Hepatitis B, Chron

2013
Single-dose and multiple-dose pharmacokinetics and safety of telbivudine after oral administration in healthy Chinese subjects.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:9

    Topics: Administration, Oral; Adult; China; Dose-Response Relationship, Drug; Drug-Related Side Effects and

2006

Other Studies

8 other studies available for thymidine and Adverse Drug Event

ArticleYear
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
A comparison of efficacy and safety of 2-year telbivudine and entecavir treatment in patients with chronic hepatitis B: a match-control study.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2014, Volume: 20, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Res

2014
Efficacy of telbivudine compared with entecavir in hepatitis B virus-related cirrhosis: 2 year follow-up data.
    Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:3

    Topics: Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug-Related Side Effects and Adverse R

2015
Comparison of renal safety and efficacy of telbivudine, entecavir and tenofovir treatment in chronic hepatitis B patients: real world experience.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2016, Volume: 22, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug-Related Side Effects and Adverse Reactions; F

2016
Telbivudine versus lamivudine and entecavir for treatment-naïve decompensated hepatitis B virus-related cirrhosis.
    Clinical and experimental medicine, 2017, Volume: 17, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug-Related Side Effects and Adver

2017
Long-term safety and efficacy of telbivudine in infants born to mothers treated during the second or third trimesters of pregnancy.
    Journal of viral hepatitis, 2017, Volume: 24, Issue:6

    Topics: Adult; Antiviral Agents; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female;

2017
Comparison of flow cytometric analysis and [3H]thymidine incorporation for measurement of the effects of drug toxicity on lymphocyte stimulation.
    Antimicrobial agents and chemotherapy, 1983, Volume: 24, Issue:4

    Topics: Bromodeoxyuridine; Cytarabine; DNA; Drug-Related Side Effects and Adverse Reactions; Flow Cytometry;

1983
Use of aggregating cell cultures for toxicological studies.
    Experientia, 1988, Oct-15, Volume: 44, Issue:10

    Topics: Animals; beta-Alanine; Biotransformation; Brain; Cell Aggregation; Cell Division; Cells, Cultured; C

1988