thymidine has been researched along with Acute Lymphoid Leukemia in 20 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " To further investigate this possible therapeutic approach we used a whole blood assay to characterize the proliferative responsiveness (3H-thymidine incorporation) of circulating T cells from AML patients with severe treatment-induced leukopenia, i." | 3.72 | Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia. ( Bruserud, Ø; Ernst, P; Nesthus, I; Paulsen, K; Sjo, M; Wendelbo, Ø, 2004) |
| "Twenty patients who received high-dose methotrexate for osteosarcoma (n = 11), lymphoid cancers (n = 8), and gastric cancer (n = 1) developed nephrotoxicity (median serum creatinine, 3." | 3.69 | Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction. ( Adamson, PC; Balis, FM; Montello, MJ; Murphy, RF; O'Brien, M; Sorensen, JM; Widemann, BC, 1997) |
| "It is uncertain if acute lymphoblastic leukemia (ALL) cells expressing myeloid makers can respond to granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF)." | 2.68 | Heterogeneous effects of G-CSF and GM-CSF on cell growth and ara-C cytotoxicity in childhood leukemias which express myeloid markers. ( Cao, DC; Higashigawa, M; Hori, H; Ido, M; Kawasaki, H; Komada, Y; Kuwabara, H; Ohkubo, T; Sakurai, M, 1996) |
| "Acute lymphoblastic leukemia (ALL) with mixed lineage leukemia (MLL) gene rearrangements (MLL+ALL) has a dismal prognosis and is characterized by high surface CD44 expression." | 1.46 | Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression. ( Abe, M; Ando, N; Furuichi, Y; Goi, K; Inukai, T; Kagami, K; Kasai, S; Nagano, O; Nakane, T; Ohno, S; Okazaki, S; Saitoh, S; Saya, H; Sugita, K, 2017) |
| "We show that acute lymphoblastic leukemia (ALL) cells avoid lethal replication stress after thymidine (dT)-induced inhibition of DNP dCTP synthesis by switching to NSP-mediated dCTP production." | 1.40 | Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. ( Armijo, AL; Austin, WR; Boulos, N; Campbell, DO; Czernin, J; Darvish, R; Dimitrova, E; Faull, KF; Gordin, A; Herschman, HR; Jung, ME; Lavie, A; Le, TM; Lee, JT; Li, Z; Liao, HI; Martin, C; Murphy, JM; Nathanson, DA; Nomme, J; Phelps, ME; Radu, CG; Sadeghi, S; Ta, L; Tom, M; Wei, L; Wilks, M, 2014) |
| "Neoplastic cells of childhood acute lymphoblastic leukemia (ALL) with natural killer (NK) cell properties were studied for the expression of p75 interleukin-2 receptors (IL-2R) and the receptor functions." | 1.28 | Functional p75 interleukin-2 receptor expression on the fresh blast cells in childhood acute lymphoblastic leukemia with natural killer cell properties. ( Ichikawa, M; Kawai, H; Kinoshita, A; Komiyama, A; Miyasaka, M; Nakazawa, S; Tsudo, M, 1991) |
| "Using JM and MOLT3, two human T-cell acute lymphoblastic leukemia cell lines, we investigated the ability of 24-h thymidine exposures to enhance the cytotoxicity of cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) (carboplatin)." | 1.28 | Interactions of thymidine, hyperthermia, and cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) in human T-cell leukemia. ( Cohen, JD; Robins, HI; Schmitt, CL; Tanner, MA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kasai, S | 1 |
| Furuichi, Y | 1 |
| Ando, N | 1 |
| Kagami, K | 1 |
| Abe, M | 1 |
| Nakane, T | 1 |
| Goi, K | 1 |
| Inukai, T | 1 |
| Saitoh, S | 1 |
| Ohno, S | 1 |
| Okazaki, S | 1 |
| Nagano, O | 1 |
| Saya, H | 1 |
| Sugita, K | 1 |
| Nathanson, DA | 1 |
| Armijo, AL | 1 |
| Tom, M | 1 |
| Li, Z | 1 |
| Dimitrova, E | 1 |
| Austin, WR | 1 |
| Nomme, J | 1 |
| Campbell, DO | 1 |
| Ta, L | 1 |
| Le, TM | 1 |
| Lee, JT | 1 |
| Darvish, R | 1 |
| Gordin, A | 1 |
| Wei, L | 1 |
| Liao, HI | 1 |
| Wilks, M | 1 |
| Martin, C | 1 |
| Sadeghi, S | 1 |
| Murphy, JM | 1 |
| Boulos, N | 1 |
| Phelps, ME | 1 |
| Faull, KF | 1 |
| Herschman, HR | 1 |
| Jung, ME | 1 |
| Czernin, J | 1 |
| Lavie, A | 1 |
| Radu, CG | 1 |
| Hegazy, AN | 1 |
| Klein, C | 1 |
| Wendelbo, Ø | 1 |
| Nesthus, I | 1 |
| Sjo, M | 1 |
| Paulsen, K | 1 |
| Ernst, P | 1 |
| Bruserud, Ø | 1 |
| Roychowdhury, S | 1 |
| Baiocchi, RA | 1 |
| Vourganti, S | 1 |
| Bhatt, D | 1 |
| Blaser, BW | 1 |
| Freud, AG | 1 |
| Chou, J | 1 |
| Chen, CS | 2 |
| Xiao, JJ | 1 |
| Parthun, M | 1 |
| Chan, KK | 1 |
| Eisenbeis, CF | 1 |
| Ferketich, AK | 1 |
| Grever, MR | 1 |
| Caligiuri, MA | 1 |
| Gangjee, A | 1 |
| Devraj, R | 1 |
| McGuire, JJ | 1 |
| Kisliuk, RL | 1 |
| Haber, M | 1 |
| Norris, MD | 1 |
| Kavallaris, M | 1 |
| Camacho, M | 1 |
| Madafiglio, J | 1 |
| Baker, CJ | 1 |
| White, L | 1 |
| Stewart, BW | 2 |
| Taskén, K | 2 |
| Andersson, KB | 2 |
| Erikstein, BK | 1 |
| Hansson, V | 1 |
| Jahnsen, T | 1 |
| Blomhoff, HK | 2 |
| Christoffersen, J | 1 |
| Smeland, EB | 1 |
| Stokke, T | 1 |
| van der Plas, DC | 1 |
| Smiers, F | 1 |
| Pouwels, K | 2 |
| Hoefsloot, LH | 1 |
| Löwenberg, B | 2 |
| Touw, IP | 2 |
| Higashigawa, M | 1 |
| Kuwabara, H | 1 |
| Cao, DC | 1 |
| Hori, H | 1 |
| Ohkubo, T | 1 |
| Kawasaki, H | 1 |
| Ido, M | 1 |
| Komada, Y | 1 |
| Sakurai, M | 1 |
| Widemann, BC | 1 |
| Balis, FM | 1 |
| Murphy, RF | 1 |
| Sorensen, JM | 1 |
| Montello, MJ | 1 |
| O'Brien, M | 1 |
| Adamson, PC | 1 |
| Sackey, FN | 1 |
| Watson, CS | 1 |
| Gametchu, B | 1 |
| Barnes, MJ | 1 |
| Taylor, GA | 1 |
| Newell, DR | 1 |
| Jeanteur, P | 1 |
| Ichikawa, M | 1 |
| Kawai, H | 1 |
| Komiyama, A | 1 |
| Tsudo, M | 1 |
| Miyasaka, M | 1 |
| Kinoshita, A | 1 |
| Nakazawa, S | 1 |
| Catchpoole, D | 1 |
| Bökkerink, JP | 1 |
| Damen, FJ | 1 |
| Hulscher, MW | 1 |
| Bakker, MA | 1 |
| De Abreu, RA | 1 |
| van Agthoven, AJ | 1 |
| van Gurp, R | 1 |
| Delwel, R | 1 |
| Hagemeijer, A | 1 |
| Hählen, K | 1 |
| Cohen, JD | 1 |
| Robins, HI | 1 |
| Schmitt, CL | 1 |
| Tanner, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Trial of Carboxypeptidase-G2 (CPDG2) and Thymidine for the Management of Patients With Methotrexate Toxicity and Renal Dysfunction[NCT00001298] | Phase 1 | 10 participants | Interventional | 1992-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for thymidine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Heterogeneous effects of G-CSF and GM-CSF on cell growth and ara-C cytotoxicity in childhood leukemias which express myeloid markers.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; C | 1996 |
19 other studies available for thymidine and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.
Topics: Biological Transport; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Female; Gene Express | 2017 |
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
Topics: Animals; Biosynthetic Pathways; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Disease Eradication | 2014 |
Ex vivo priming of CD4 T cells converts immunological tolerance into effective antitumor immunity in a murine model of acute lymphoblastic leukemia.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Dendritic Cells; Disease Models, Animal; Fe | 2008 |
Functional characterization of T lymphocytes derived from patients with acute myelogenous leukemia and chemotherapy-induced leukopenia.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; CD28 Antigen | 2004 |
Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder.
Topics: Animals; Antineoplastic Agents; Apoptosis; Burkitt Lymphoma; Caspase Inhibitors; Cell Division; Cell | 2004 |
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
Topics: Antineoplastic Agents; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Hypoxanthine; Hypo | 1995 |
An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro.
Topics: Animals; Cryopreservation; Freezing; Methotrexate; Mice; Mice, Nude; Neoplasm Transplantation; Precu | 1995 |
Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.
Topics: B-Lymphocytes; Blotting, Northern; Cell Division; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protei | 1994 |
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells.
Topics: B-Lymphocytes; Cell Cycle; Cell Division; Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Humans; Mi | 1994 |
Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain.
Topics: Animals; Antigens, CD; B-Lymphocytes; Base Sequence; Burkitt Lymphoma; Cell Line; DNA Primers; DNA-B | 1996 |
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.
Topics: Adolescent; Adult; Antidotes; Antimetabolites, Antineoplastic; Carboxypeptidases; Child; Child, Pres | 1997 |
Cell cycle regulation of membrane glucocorticoid receptor in CCRF-CEM human ALL cells: correlation to apoptosis.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Membrane; Demecolcine; DNA, Neoplasm; G1 Phase; Gene | 1997 |
Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Child; Guanine; Humans; Inosine; Leukemia; Methotrexate; P | 2000 |
[Nutrition, genetic polymorphism, and cancer].
Topics: Colorectal Neoplasms; DNA; DNA Repair; Folic Acid; Genotype; Humans; Methylenetetrahydrofolate Reduc | 2000 |
Functional p75 interleukin-2 receptor expression on the fresh blast cells in childhood acute lymphoblastic leukemia with natural killer cell properties.
Topics: Adolescent; Antibodies, Monoclonal; Antigens, CD; Blast Crisis; Cell Division; Histocytochemistry; H | 1991 |
Structural analysis of replicating DNA following exposure to cytotoxic drugs: implications for current models of DNA synthesis in mammalian cells.
Topics: Antineoplastic Agents; Cell Line; Chromatography, DEAE-Cellulose; DNA; DNA Replication; DNA, Single- | 1990 |
Biochemical evidence for synergistic combination treatment with methotrexate and 6-mercaptopurine in acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Drug Synergism; Humans; Lymphocytes; | 1990 |
Role of interleukin-7 in the growth of acute lymphoblastic leukemia.
Topics: Cell Division; DNA, Neoplasm; Humans; Interleukin-7; Precursor Cell Lymphoblastic Leukemia-Lymphoma; | 1990 |
Interactions of thymidine, hyperthermia, and cis-diammine-1,1-cyclobutane dicarboxylate platinum (II) in human T-cell leukemia.
Topics: Antineoplastic Agents; Carboplatin; Cell Line; Cell Survival; Drug Synergism; Heart; Humans; Organop | 1989 |