thymidine has been researched along with AIDS-Related Complex in 20 studies
AIDS-Related Complex: A prodromal phase of infection with the human immunodeficiency virus (HIV). Laboratory criteria separating AIDS-related complex (ARC) from AIDS include elevated or hyperactive B-cell humoral immune responses, compared to depressed or normal antibody reactivity in AIDS; follicular or mixed hyperplasia in ARC lymph nodes, leading to lymphocyte degeneration and depletion more typical of AIDS; evolving succession of histopathological lesions such as localization of Kaposi's sarcoma, signaling the transition to the full-blown AIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a double-blind, placebo-controlled trial of the efficacy of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) manifested by Pneumocystis carinii pneumonia alone, or with advanced AIDS-related complex." | 9.06 | The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. ( Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Schooley, RT; Volberding, PA, 1987) |
| "We conducted a double-blind, placebo-controlled trial of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex." | 9.06 | The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. ( Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Hirsch, MS; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Volberding, PA, 1987) |
| "On the basis of observation that acyclovir potentiates the in-vitro antiviral activity of 3-azido-2',3'-dideoxythymidine (also known as azidothymidine or zidovudine) against human immunodeficiency virus (HIV), we administered a regimen of azidothymidine and acyclovir to eight patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex." | 7.67 | Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study. ( Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R, 1988) |
| "Zidovudine was present in the semen and serum of six patients with acquired immunodeficiency syndrome or the related complex who were receiving 200 mg of the drug orally every four to six hours." | 7.67 | Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex. ( Balfour, HH; Chinnock, BJ; de Miranda, P; Fletcher, CV; Henry, K; Quinn, RP, 1988) |
| "Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma." | 6.66 | Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT). ( Despotes, JC; Emeson, EE; Falk, LA; Jackson, GG; Knigge, M; Mack, D; Paul, DA; Rubenis, M, 1988) |
| "We conducted a double-blind, placebo-controlled trial of the efficacy of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) manifested by Pneumocystis carinii pneumonia alone, or with advanced AIDS-related complex." | 5.06 | The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. ( Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Schooley, RT; Volberding, PA, 1987) |
| "We conducted a double-blind, placebo-controlled trial of oral azidothymidine (AZT) in 282 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex." | 5.06 | The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial. ( Fischl, MA; Gottlieb, MS; Grieco, MH; Groopman, JE; Hirsch, MS; Laskin, OL; Leedom, JM; Mildvan, D; Richman, DD; Volberding, PA, 1987) |
| "Five dose regimens of 2',3'-dideoxycytidine (ddC) were administered, intravenously for 2 weeks then orally for 4 or more weeks, to 20 patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC)." | 3.67 | Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT). ( Allain, JP; Dubinsky, R; Fischl, MA; Klecker, RW; McAtee, N; McNeely, MC; Perno, CF; Thomas, RV; Wills, RJ; Yarchoan, R, 1988) |
| "In a study of treatment by zidovudine in 106 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, an acute meningo-encephalitic illness developed in 4 of 21 patients within 17 days after the dose of zidovudine had had to be reduced because of myelotoxicity." | 3.67 | Acute meningo-encephalitis on dose reduction of zidovudine. ( Forster, S; Helbert, M; Jeffries, D; Kocsis, A; Peddle, B; Pinching, AJ; Robinson, D, 1988) |
| "On the basis of observation that acyclovir potentiates the in-vitro antiviral activity of 3-azido-2',3'-dideoxythymidine (also known as azidothymidine or zidovudine) against human immunodeficiency virus (HIV), we administered a regimen of azidothymidine and acyclovir to eight patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex." | 3.67 | Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study. ( Allain, JP; Blum, MR; Lehrman, SN; Leuther, M; Maha, M; McAtee, N; Mitsuya, H; Surbone, A; Thomas, RV; Yarchoan, R, 1988) |
| "Zidovudine was present in the semen and serum of six patients with acquired immunodeficiency syndrome or the related complex who were receiving 200 mg of the drug orally every four to six hours." | 3.67 | Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex. ( Balfour, HH; Chinnock, BJ; de Miranda, P; Fletcher, CV; Henry, K; Quinn, RP, 1988) |
| "Among 16 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex studied serially, 12 had or developed antigenemia ranging from 16 to 3006 pg/mL in plasma." | 2.66 | Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT). ( Despotes, JC; Emeson, EE; Falk, LA; Jackson, GG; Knigge, M; Mack, D; Paul, DA; Rubenis, M, 1988) |
| "1." | 2.39 | [In vitro synergic lymphocyte stimulation in HIV-1 infected patients using inosine derivatives and radio-detoxified endotoxin]. ( Bertók, L; Friedman, H; Hadden, JW; Nelson, R; Ongrádi, J; Specter, S, 1995) |
| "Persons with the acquired immunodeficiency syndrome (AIDS) (n = 25), AIDS-related complex (n = 14), and HIV-seropositive men with only lymphadenopathy or no symptoms (n = 27)." | 1.27 | The influence of human immunodeficiency virus (HIV) infection on antibody responses to influenza vaccines. ( Clements, ML; Cohn, S; Miotti, P; Nelson, KE; Polk, BF, 1988) |
| "The basic pharmacokinetic and bioavailability information on zidovudine was obtained during the initial phase I study." | 1.27 | Pharmacokinetics and bioavailability of zidovudine in humans. ( Blum, MR; de Miranda, P; Good, SS; Liao, SH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (95.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ongrádi, J | 1 |
| Hadden, JW | 1 |
| Bertók, L | 1 |
| Specter, S | 1 |
| Nelson, R | 1 |
| Friedman, H | 1 |
| Duvic, M | 1 |
| Rios, A | 1 |
| Brewton, GW | 1 |
| Yarchoan, R | 2 |
| Perno, CF | 1 |
| Thomas, RV | 2 |
| Klecker, RW | 1 |
| Allain, JP | 2 |
| Wills, RJ | 1 |
| McAtee, N | 2 |
| Fischl, MA | 3 |
| Dubinsky, R | 1 |
| McNeely, MC | 1 |
| Fleury, HJ | 1 |
| Morere, G | 1 |
| Delord, B | 1 |
| Faivre, R | 1 |
| Helbert, M | 1 |
| Robinson, D | 1 |
| Peddle, B | 1 |
| Forster, S | 1 |
| Kocsis, A | 1 |
| Jeffries, D | 1 |
| Pinching, AJ | 1 |
| Surbone, A | 1 |
| Blum, MR | 2 |
| Maha, M | 1 |
| Mitsuya, H | 1 |
| Lehrman, SN | 1 |
| Leuther, M | 1 |
| Nelson, KE | 1 |
| Clements, ML | 1 |
| Miotti, P | 1 |
| Cohn, S | 1 |
| Polk, BF | 1 |
| Offerhaus, L | 1 |
| Jackson, GG | 1 |
| Paul, DA | 1 |
| Falk, LA | 1 |
| Rubenis, M | 1 |
| Despotes, JC | 1 |
| Mack, D | 1 |
| Knigge, M | 1 |
| Emeson, EE | 1 |
| Henry, K | 1 |
| Chinnock, BJ | 1 |
| Quinn, RP | 1 |
| Fletcher, CV | 1 |
| de Miranda, P | 2 |
| Balfour, HH | 1 |
| Liao, SH | 1 |
| Good, SS | 1 |
| Hirsch, MS | 2 |
| Richman, DD | 2 |
| Grieco, MH | 2 |
| Gottlieb, MS | 2 |
| Volberding, PA | 2 |
| Laskin, OL | 2 |
| Leedom, JM | 2 |
| Groopman, JE | 2 |
| Mildvan, D | 2 |
| Schooley, RT | 1 |
| Bessen, LJ | 1 |
| Greene, JB | 1 |
| Louie, E | 1 |
| Seitzman, P | 1 |
| Weinberg, H | 1 |
| Kolata, G | 1 |
2 reviews available for thymidine and AIDS-Related Complex
| Article | Year |
|---|---|
[In vitro synergic lymphocyte stimulation in HIV-1 infected patients using inosine derivatives and radio-detoxified endotoxin].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Endotoxins; HIV Infections; HIV-1; | 1995 |
AIDS commentary. Azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Humans; T | 1988 |
6 trials available for thymidine and AIDS-Related Complex
| Article | Year |
|---|---|
[Azidothymidine and HIV infection].
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic | 1987 |
Human immunodeficiency virus (HIV) antigenemia (p24) in the acquired immunodeficiency syndrome (AIDS) and the effect of treatment with zidovudine (AZT).
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antigens, Viral; Antiviral Agents; Clinica | 1988 |
AIDS commentary. Azidothymidine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Clinical Trials as Topic; Humans; T | 1988 |
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Clinical Trials as Topic | 1987 |
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; AIDS-Related Complex; Anemia; Antiviral Ag | 1987 |
Azidothymidine for AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Bone Marrow Diseases; Clinical Tria | 1986 |
13 other studies available for thymidine and AIDS-Related Complex
| Article | Year |
|---|---|
Remission of AIDS-associated psoriasis with zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Humans; Male; Psoriasis; Thymidine; | 1987 |
Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT).
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Deoxycytidine; Drug Administration | 1988 |
Isolation of HIV from mononuclear cells of patients receiving zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; HIV; Humans; Leuk | 1988 |
Acute meningo-encephalitis on dose reduction of zidovudine.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Complex; Antiviral Agents; Fo | 1988 |
Treatment of the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex with a regimen of 3'-azido-2',3'-dideoxythymidine (azidothymidine or zidovudine) and acyclovir. A pilot study.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; AIDS-Related Complex; Antiviral Agents; Drug I | 1988 |
The influence of human immunodeficiency virus (HIV) infection on antibody responses to influenza vaccines.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antibodies, Viral; Antiviral Agents | 1988 |
Concurrent zidovudine levels in semen and serum determined by radioimmunoassay in patients with AIDS or AIDS-related complex.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Chromatography, High Pressure Liquid; Huma | 1988 |
Pharmacokinetics and bioavailability of zidovudine in humans.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Antiviral Agents; Biological Availa | 1988 |
Azidothymidine in the treatment of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Complex; Humans; Male; Thymidine; Zidovudine | 1988 |
Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Humans; Myositis; Thymidine; Zidovudine | 1988 |
FDA approves AZT.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Humans; Thymidine; United States; United S | 1987 |
Update on AZT for AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Drug Interactions; Hemat | 1987 |
Zidovudine for AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Antiviral Agents; Humans; Thymidine; Zidov | 1987 |