thymic-humoral-factor-gamma-2 and Hepatitis-D

thymic-humoral-factor-gamma-2 has been researched along with Hepatitis-D* in 1 studies

Other Studies

1 other study(ies) available for thymic-humoral-factor-gamma-2 and Hepatitis-D

ArticleYear
Treatment of chronic hepatitis D with thymus-derived polypeptide thymic humoral factor-gamma 2: a pilot study.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2002, Volume: 34, Issue:4

    Thymic humoral factor-gamma 2 is a thymus-derived synthetic octapeptide, shown to be effective in chronic hepatitis B virus infection; as the latter is needed to support hepatitis D virus, thymic humoral factor-gamma 2 may have a therapeutic role in hepatitis D.. To evaluate tolerability and efficacy of thymic humoral factor-gamma 2 in chronic hepatitis D.. Intramuscular thymic humoral factor-gamma 2, 40 microg, was given for 15 consecutive days and twice weekly for 22 additional weeks to adult patients with chronic hepatitis D virus hepatitis.. A total of 11 patients (male/female 9/2, mean age 45.9 years] completed the treatment period, 10 the 6-month follow-up. At baseline, hepatitis D virus-RNA was positive in 8/11 (73%) patients. During treatment, hepatitis D virus-RNA became undetectable in 3/8 (37%), decreased in 1/8 (13%), remained unchanged in 4/8 (50%) and persisted undetectable in 3 patients, negative at baseline. During follow-up hepatitis D-viraemia relapsed in all patients but 2, one already negative at baseline. No changes in hepatitis B virus markers occurred. Mean serum alanine aminotransferase levels did not change significantly None of the patients reached normal serum alanine aminotransferase levels.. At the doses given, thymic humoral factor-gamma 2 has been of limited efficacy A possible role of thymic humoral factor-gamma 2 in the treatment of chronic hepatitis D requires further dose-finding studies and/or combination with other antivirals.

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Alanine Transaminase; Female; Hepatitis D; Hepatitis D, Chronic; Humans; Male; Middle Aged; Oligopeptides; Pilot Projects; RNA, Viral; Treatment Outcome

2002