thymic-factor--circulating and Neoplasm-Metastasis

The effect of thymalin and epithalamin on dissemination of tumors treated by pulsed laser radiation was studied in C57B1 female mice bearing subcutaneously transplanted melanoma B16 and Lewis carcinoma. Radiation was delivered from TOC-1001 neodymium laser, wave-length of 1,060 nm, pulse duration--1 msec and fluence--350-400 J/cm2. Drug dosage was 1 mg. Thymalin and epithalamin treatment potentiated the preventive effect of laser radiation on tumor dissemination. Application of the said agents was followed by an increase in antibody-producing cells (as measured by Jerne's procedure) in the spleen of irradiated melanoma B16--bearing mice.

Topics: Adjuvants, Immunologic; Animals; Combined Modality Therapy; Laser Therapy; Male; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Peptides; Thymus Hormones; Time Factors