thymic-factor--circulating and Lymphopenia

Topics: Adult; Aged; Animals; Antibody-Producing Cells; Cell Membrane; Child; Female; Humans; Hypersensitivity, Delayed; Immunologic Deficiency Syndromes; Lymphocyte Activation; Lymphopenia; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Nutrition Disorders; Pregnancy; T-Lymphocytes, Cytotoxic; Thymic Factor, Circulating; Zinc

The thymic peptide thymaline combined with psychotropic drugs was used in the treatment of 36 therapeutically resistant patients with pronounced immune abnormalities. Such a policy favoured considerable enhancement of the treatment efficacy which manifested itself by the elimination or amelioration of psychic disorders, appreciable activation of patients and reduction of neuroleptic complications. The positive dynamics in the patients' status always correlated with the normalization of immune abnormalities, with this being seen to a greater degree in cases of the secondary "pharmacogenic" resistance and resistance because of the "pathological ground". On the one hand, the studies demonstrated wide potentialities of the use of thymaline in the treatment of the resistant patterns of schizophrenia. On the other hand, they showed the heterogeneity of immune abnormalities in patients with different varieties of resistance.

Topics: Adjuvants, Immunologic; Adolescent; Adult; Clinical Trials as Topic; Drug Resistance; Female; Humans; Leukocyte Count; Lymphopenia; Male; Middle Aged; Placebos; Psychotropic Drugs; Schizophrenia; T-Lymphocytes; Thymus Hormones

A total of 84 women with normal pregnancy and those with threatened abortions were examined, as were 28 healthy nonpregnant women, to estimate the function of the thymus. The findings evidence enhancement of the endocrine function of the thymus in pregnancy, this function being assessed from the thymic serum factor titer. The function activation is related to pregnancy course and is more marked in threatened abortion. Before labor the thymic serum factor titers are the highest and they persist high after spontaneous delivery. The biological sense of thymic hormonal function activation in pregnancy is discussed, as are the possible mechanisms of this phenomenon.

Topics: Abortion, Threatened; Female; Fetus; Humans; Leukocyte Count; Lymphopenia; Pregnancy; Reference Values; T-Lymphocytes, Regulatory; Thymic Factor, Circulating; Thymus Gland

Addition of immunomodulating therapy with Thymalin, a thymus agent, to the multimodality therapy of burnt patients contributes to a rapid normalization of immunological parameters. The most marked immune response was observed 7-10 days after a therapy course initiated in the early periods of burn disease in patients with severely depressed T-system immunity and a high sensitivity to the drug. Inclusion of a donor blood leukomass transfusion course activates the cellular link of the immune system just after the treatment course, but fails to favour a stable normalization of thymus-dependent lymphocyte ratios.

Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; Blood Transfusion; Burns; Combined Modality Therapy; Humans; Leukocyte Count; Lymphopenia; Middle Aged; T-Lymphocytes; Thymus Hormones

A colony of German shepherd dogs was studied in which a high proportion of antinuclear antibody (ANAb) carriers and dogs with systemic lupus erythematosus (SLE)-like signs were found. The titre of serum thymulin and the percentage of circulating T lymphocytes were both low. The incidence of disease decreased down the generations through the introduction of outside sires, thus suggesting a genetic origin for the disease.

Topics: Animals; Antibodies, Antinuclear; Breeding; Dogs; Joints; Kidney; Lupus Erythematosus, Systemic; Lymphopenia; Skin; T-Lymphocytes; Thrombocytopenia; Thymic Factor, Circulating

Topics: Adjuvants, Immunologic; Child; Child, Preschool; Chronic Disease; Hepatitis B; Humans; Leukocyte Count; Lymphopenia; T-Lymphocytes; Thymus Hormones

Topics: Animals; Female; Lung; Lymphopenia; Rats; Thymectomy; Thymus Hormones; Tuberculosis, Pulmonary

Topics: Adjuvants, Immunologic; Animals; Cattle; Humans; Lymphopenia; Male; Middle Aged; T-Lymphocytes; Thymectomy; Thymus Hormones