thymic-factor--circulating and Lymphoma

thymic-factor--circulating has been researched along with Lymphoma* in 2 studies

Other Studies

2 other study(ies) available for thymic-factor--circulating and Lymphoma

Article	Year
Immune modulation of a T-suppressor cell lymphoma by thymic humoral factor, a thymic hormone. Cancer, 1984, Nov-15, Volume: 54, Issue:10 Lymphoid cells obtained from a mediastinal mass and bone marrow as well as peripheral blood of a patient with poorly differentiated diffuse malignant lymphoma were found to have both E and complement receptors. Addition of the bone marrow lymphoblasts to normal human T-lymphocytes induced a suppression of normal T functional activity as measured by a local xenogeneic graft versus host reaction. Incubation of the same cells with thymic humoral factor (THF), a thymic hormone, reversed their functional activity from suppression to help. Control studies with normal T-suppressor lymphocytes also showed a reversal of function to helper activity upon incubation with THF. In studies of normal T-lymphocytes with monoclonal antibodies, incubation with THF induced no change in phenotype in either theophylline-sensitive (suppressor) cells or theophylline-resistant (helper) cells. The ability of THF to modulate helper and suppressor activities suggests that this or similar agents may provide a useful means of therapy for disorders of immunoregulation. Topics: Adult; Antibodies, Monoclonal; Bone Marrow; Graft vs Host Reaction; Humans; In Vitro Techniques; Lymph Nodes; Lymphoma; Male; Mediastinal Neoplasms; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Theophylline; Thymic Factor, Circulating; Thymus Hormones	1984
[Suppression of thymus endocrine function and changes in the plasma membrane properties of the lymphocytes in the chemotherapy of systemic oncological diseases in children]. Voprosy onkologii, 1983, Volume: 29, Issue:5 An examination of 16 children suffering from malignancies established marked chemotherapy--induced suppression of endocrine function of the thymus. These findings were in correlation with variations in peripheral blood lymphocytes level in spontaneous rosette-formation test with ovine red blood cells and autoerythrocytes. The levels of E- and A-rosette-forming cells returned to normal following in vitro incubation of peripheral blood lymphocytes with thymostimuline. It is suggested that immunocorrection by means of thymal hormones should be carried out in the course of chemotherapy. Topics: Adolescent; Cell Membrane; Child; Cyclophosphamide; Depression, Chemical; Hodgkin Disease; Humans; Lymphocytes; Lymphoma; Rosette Formation; Thymic Factor, Circulating; Thymus Gland; Time Factors; Vinblastine	1983

Article

Year

Immune modulation of a T-suppressor cell lymphoma by thymic humoral factor, a thymic hormone.

Cancer, 1984, Nov-15, Volume: 54, Issue:10

Lymphoid cells obtained from a mediastinal mass and bone marrow as well as peripheral blood of a patient with poorly differentiated diffuse malignant lymphoma were found to have both E and complement receptors. Addition of the bone marrow lymphoblasts to normal human T-lymphocytes induced a suppression of normal T functional activity as measured by a local xenogeneic graft versus host reaction. Incubation of the same cells with thymic humoral factor (THF), a thymic hormone, reversed their functional activity from suppression to help. Control studies with normal T-suppressor lymphocytes also showed a reversal of function to helper activity upon incubation with THF. In studies of normal T-lymphocytes with monoclonal antibodies, incubation with THF induced no change in phenotype in either theophylline-sensitive (suppressor) cells or theophylline-resistant (helper) cells. The ability of THF to modulate helper and suppressor activities suggests that this or similar agents may provide a useful means of therapy for disorders of immunoregulation.

Topics: Adult; Antibodies, Monoclonal; Bone Marrow; Graft vs Host Reaction; Humans; In Vitro Techniques; Lymph Nodes; Lymphoma; Male; Mediastinal Neoplasms; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Theophylline; Thymic Factor, Circulating; Thymus Hormones

1984

[Suppression of thymus endocrine function and changes in the plasma membrane properties of the lymphocytes in the chemotherapy of systemic oncological diseases in children].

Voprosy onkologii, 1983, Volume: 29, Issue:5

An examination of 16 children suffering from malignancies established marked chemotherapy--induced suppression of endocrine function of the thymus. These findings were in correlation with variations in peripheral blood lymphocytes level in spontaneous rosette-formation test with ovine red blood cells and autoerythrocytes. The levels of E- and A-rosette-forming cells returned to normal following in vitro incubation of peripheral blood lymphocytes with thymostimuline. It is suggested that immunocorrection by means of thymal hormones should be carried out in the course of chemotherapy.

Topics: Adolescent; Cell Membrane; Child; Cyclophosphamide; Depression, Chemical; Hodgkin Disease; Humans; Lymphocytes; Lymphoma; Rosette Formation; Thymic Factor, Circulating; Thymus Gland; Time Factors; Vinblastine

1983