thymic-factor--circulating and Immune-System-Diseases

Topics: Humans; Immune System Diseases; Immunotherapy; Lymphokines; Thymic Factor, Circulating; Thymus Hormones; Transfer Factor

Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Cattle; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Immune System Diseases; Immunity, Cellular; Peptides; Thymus Gland; Thymus Hormones

Topics: Adjuvants, Immunologic; Adult; Disease Susceptibility; Disopyramide; Drug Therapy, Combination; Female; Humans; Immune System Diseases; Male; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Thymus Hormones; Wolff-Parkinson-White Syndrome

After subchronic intoxication with synthetic sumi-alpha pirethroid rats developed pronounced changes of macrophagocytic function; reduction of cell-mediated and humoral immunity, accumulation of pathogenic circulating immune complexes. In these conditions one-week thymalin treatment produced a normalizing effect. Sodium nucleinate was of low efficacy.

Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Drug Evaluation, Preclinical; Immune System Diseases; Immunity, Cellular; Nitriles; Nucleic Acids; Poisoning; Pyrethrins; Rats; Rats, Wistar; Thymus Hormones; Time Factors

Examination of the immunologic state of 73 patients with rhegmatogenous retinal detachment complicated by vitreoretinal proliferation has revealed correlation between the severity of the latter and disturbances in the immune state of the patient's body. 44% of patients with the stage C and 62% of patients with the stage D have immunodeficiency expressed by reduced level of T- and B-lymphocytes and their subpopulation. It is shown that disturbances in immunoreactivity can serve as an unfavourable sign for prognosis of effectiveness of surgical intervention in patients with rhegmatogenous retinal detachment. In 70% of the patients these disturbances lead to unfavourable outcome of the operation. For normalization of the revealed disturbances in the immune state, immunomodulator thymaline was used in a complex treatment of 17 patients. The preparation rose the effectiveness of the treatment in 78% of patients and reduced the number of postoperative complications. It is recommended to study the immunologic state of the patient with rhegmatogenous retinal detachment complicated by vitreoretinal proliferation for the purpose of its further correction and a higher effectiveness of surgical treatment of such patients.

Topics: Adjuvants, Immunologic; Antibody Formation; Drug Evaluation; Eye Diseases; Humans; Immune System Diseases; Immunity, Cellular; Retinal Detachment; Thymus Hormones; Vitreous Body

Thymalin administration to two-week-old offspring of neurosensitized female rats prevented the development of protein synthesis disturbances in the central nervous system and the retention of conditioned reflex of passive avoidance. Thymalin injection to the offspring of intact female rats improved conditioned reflex retention and did not affect brain protein synthesis. A possible mechanism of thymalin effect in conditions of congenital neuroimmunopathology is discussed.

Topics: Adjuvants, Immunologic; Animals; Brain; Conditioning, Classical; Female; Fetal Proteins; Immune System Diseases; Nerve Tissue Proteins; Pregnancy; Rats; Thymus Hormones

Thymic hormonal function, as assessed by thymic serum factor (FTS) titres, is reduced in melanoma. Correlation analysis was used to show dysfunctions of this gland to play an important role in the pathogenesis of changes occurring in cellular and humoral immune responses in tumor patients. The authors make a case for treatment with biologically active factors of the thymus or thymosin-like preparations as early as in T1 melanoma.

Topics: Adult; Female; Humans; Immune System Diseases; Immunity, Cellular; Immunoglobulins; Male; Melanoma; Middle Aged; Rosette Formation; Skin Neoplasms; Thymic Factor, Circulating; Thymus Hormones