thymic-factor--circulating and Hepatitis-B

Topics: Adjuvants, Immunologic; Chronic Disease; Drug Evaluation; Hepatitis; Hepatitis B; Hepatitis, Chronic; Humans; Liver Cirrhosis; Liver Diseases; Peptides; Thymus Extracts; Thymus Hormones

Topics: Adjuvants, Immunologic; Child; Chronic Disease; Genetic Carrier Screening; Hepatitis B; Hepatitis, Chronic; Homozygote; Humans; Levamisole; Thymus Hormones

The work deals with the results of the study of T-lymphocytes and their subpopulations (active, thermostable, theophylline-sensitive and theophylline-resistant) in 102 children with chronic viral hepatitis B, depending on the effectiveness of thymalin therapy. The sensitization of lymphocytes to specific antigens was studied. Among patients with chronic viral hepatitis B and cirrhosis of the liver the homozygous phenotype of haptoglobin is registered essentially more frequently (63.6% and 82.4% respectively) than among healthy persons (44.0%). The patients of this group showed a decrease in the number of T-lymphocytes, disturbances in the suppressor/helper ratio: hypersuppression in persisting hepatitis and hyposuppression in active hepatitis. In 71.6% of cases thymalin therapy produced an effect manifested by clinico-biochemical remission, an increase in the number of T-lymphocytes, thermostable cells and the normalization of the T-suppressor/T-helper ratio. In these patients sensitization to HBsAg essentially decreased (from 30.5% to 13.9%), while sensitization to human liver lipoprotein retained its high level even after treatment with thymalin.

Topics: Adjuvants, Immunologic; Adolescent; Child; Child, Preschool; Chronic Disease; Haptoglobins; Hepatitis B; Hepatitis B Surface Antigens; Humans; Immunologic Deficiency Syndromes; Phenotype; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thymus Hormones

Topics: Adjuvants, Immunologic; Child; Chronic Disease; Drug Evaluation; Female; Hepatitis B; Humans; Male; T-Lymphocytes; Thymus Hormones

Topics: Adjuvants, Immunologic; Child; Child, Preschool; Chronic Disease; Hepatitis B; Humans; Leukocyte Count; Lymphopenia; T-Lymphocytes; Thymus Hormones