thymic-factor--circulating and Coronary-Disease

In contrast to young people, changes in the rhythms of parameters manifested in elderly and senile chronic coronary patients in inversion (decreased T cell count in the peripheral blood, values of lymphocyte blastogenesis test with phytohemagglutinin, and phagocytic index in the fall), monotony (B cell count in the peripheral blood), decreased amplitude of serum hydrocortisone, and desynchronization. The levels of thymic serum factor and IgG were higher in the fall than in the spring, but the seasonal difference leveled after 2.5 years of observation. On the other hand, the rhythms of changes in the thymic serum factor and hydrocortisone were retained in patients with chronic coronary disease after 6 courses of epithalamin by the optimal protocol (period of observation 30 months) and blood T cell count increased in the fall. Improvement of the rhythms of the parameters was associated with a benign clinical course of the disease.

Topics: Aged; Aged, 80 and over; Chronic Disease; Coronary Disease; Endocrine System; Humans; Hydrocortisone; Immune System; Immunoglobulin G; Middle Aged; Peptides; Seasons; Thymic Factor, Circulating; Time Factors

Using immunological and biochemical methods, the existence was proved of a relationship between atherogenous types of hyperlipoproteinaemia and decrease of the functional activity of the T-component of the immune system in patients with ischaemic heart disease. In IHD patients without lipid metabolism disturbances the indicators of the functional activity of the thymus-dependent factor of the immune system were reduced to a much lesser extent. The results stress the role of thymus-dependent factors and lipids in the development of ischaemic heart disease.

Topics: Adult; Angina Pectoris; Coronary Disease; Humans; Hyperlipoproteinemias; Hypertension; Immune Tolerance; Male; Middle Aged; Myocardial Infarction; T-Lymphocytes; Thymic Factor, Circulating

It was established that the use of thymalin in multimodality therapy of CHD patients suffering from attacks of angina pectoris of effort and at rest brought back to normal the state of cellular and humoral immunity, slowed down blood coagulation, decreased fibrinogen and FDP concentration, enhanced total euglobulin and Hageman-dependent fibrinolysis. A more rapid disappearance of the pain syndrome was noted in these patients as compared to those who had not received the drug.

Topics: Adult; Aged; B-Lymphocytes; Blood Coagulation; Coronary Disease; Dysgammaglobulinemia; Female; Humans; Immunoglobulins; Leukocyte Count; Male; Middle Aged; T-Lymphocytes; Thymus Hormones