thymic-factor--circulating and Chronic-Disease

We compared the effectiveness of immunomodulators used in the treatment of patients with chronic salpingitis and oophoritis with or without changes in succinate dehydrogenase (SDH) activity in blood lymphocytes at incubation with the drug. Diurnal variations in individual reaction of SDH in blood lymphocytes to thymalin or ridostin were revealed. In the groups of women receiving ridostin or thymalin during the reaction of lymphocyte SDH to it, improvement of clinical laboratory and immunological parameters was observed in the majority of the patients and no effect was found in a lesser group of patients than in the groups treated with drugs during the absence of lymphocyte SDH reaction thereto. The timing of the presence of SDH reaction to drugs in the immunocompetent cells makes it possible to set the optimal daily regime of their application and to select a drug that would be most effective in each particular case.

Topics: Adolescent; Adult; Anti-Bacterial Agents; Chronic Disease; Combined Modality Therapy; Cytoplasmic Granules; Drug Chronotherapy; Drug Therapy, Combination; Female; Humans; Immunologic Factors; Killer Cells, Natural; L-Lactate Dehydrogenase; Lymphocyte Subsets; Monocytes; Oophoritis; Physical Therapy Modalities; Precision Medicine; RNA, Double-Stranded; RNA, Fungal; Salpingitis; Succinate Dehydrogenase; Thymus Hormones; Treatment Outcome; Vitamins; Young Adult

The paper provides the results of treatment of chronic pulmonary tuberculosis patients by using immunoactive drugs (thymalin and T-activin) and prednisolone, which has been performed by monitoring immunological parameters. The patients with fibrous and cavernous tuberculosis display a combination of antituberculous antibody hyperproduction and specific cell-mediated response inhibition. Immunological hormone therapy allows normalization of the immunological status (an increase in the count and functional activity of T-lymphocytes) and relative stabilization of the process with cessation of bacterial isolation in shorter periods than in the controls, which is favourable to the reduction in hospital treatment periods.

Topics: Adjuvants, Immunologic; Antibodies, Bacterial; Chronic Disease; Combined Modality Therapy; Drug Therapy, Combination; Humans; Leukocyte Count; Mycobacterium tuberculosis; Peptides; Prednisolone; T-Lymphocytes; Thymus Extracts; Thymus Hormones; Tuberculosis, Pulmonary

Facteur thymique serique (FTS), a thymic hormone with nonapeptide is involved in T cell differentiation in intestine. Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis. BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily. FTS did not affect the course of acute colitis induced by DSS as assessed by survival rate, clinical activity of diseases, extent of tissue damage of colons. On the other hand, FTS significantly ameliorated chronic colitis induced by multiple cycles of DSS as reflected by lower lethality, weight loss, clinical scores and histological scores. The levels of interferon (IFN)-gamma, interleukin 1(IL-1)-beta, and IL-12p40 in the culture supernatants of lamina propria (LP) cells of colon without any stimulation and IFN-gamma by T cells in the LP T cells under T cell receptor (TCR) triggering were reduced in FTS-treated mice, whereas the levels of IL-10 by LP cells and LPT cells were higher in FTS-treated mice. Thus, FTS may serve to suppress inflammation in DSS-induced chronic colitis accompanied by increased IL-10 production.

Topics: Animals; Chronic Disease; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Flow Cytometry; Immunosuppressive Agents; Injections, Subcutaneous; Interferon-gamma; Interleukin-10; Mice; Mice, Inbred BALB C; Mucous Membrane; Thymic Factor, Circulating; Treatment Outcome; Weight Loss

In contrast to young people, changes in the rhythms of parameters manifested in elderly and senile chronic coronary patients in inversion (decreased T cell count in the peripheral blood, values of lymphocyte blastogenesis test with phytohemagglutinin, and phagocytic index in the fall), monotony (B cell count in the peripheral blood), decreased amplitude of serum hydrocortisone, and desynchronization. The levels of thymic serum factor and IgG were higher in the fall than in the spring, but the seasonal difference leveled after 2.5 years of observation. On the other hand, the rhythms of changes in the thymic serum factor and hydrocortisone were retained in patients with chronic coronary disease after 6 courses of epithalamin by the optimal protocol (period of observation 30 months) and blood T cell count increased in the fall. Improvement of the rhythms of the parameters was associated with a benign clinical course of the disease.

Topics: Aged; Aged, 80 and over; Chronic Disease; Coronary Disease; Endocrine System; Humans; Hydrocortisone; Immune System; Immunoglobulin G; Middle Aged; Peptides; Seasons; Thymic Factor, Circulating; Time Factors

In the past 35 years, the authors have followed up 5600 patients with sarcoidosis of respiratory organs (SRO), among whom 1.2 and 10.7% were found to have single and multiple recurrences. The clinical manifestations of recurrent sarcoidosis were moderate, by showing a drastic reduction in the count of T and T"a" lymphocytes, as well as helper lymphocytes, and an increase of circulating immune complexes and immunoglobulins G, A, and M. Poor adaptive responses (AR) defined by the blood leukocyte and lymphocyte counts that reflect the body's nonspecific responsiveness were concurrently diagnosed. In chronic recurrent SRO, poor AR as stress and superactivation amount to as much as 86.1%. To optimize treatment, the patients were given adaptogens (thymaline, levamisole, dibasole, etc.) that make AR better, by enhancing the efficiency of treatment, reducing its duration, and improving prognosis.

Topics: Adjuvants, Immunologic; Adult; Antigen-Antibody Complex; Benzimidazoles; Chronic Disease; Female; Humans; Immunoglobulins; Levamisole; Lymphocyte Count; Male; Middle Aged; Prognosis; Radiography, Thoracic; Recurrence; Sarcoidosis, Pulmonary; Thymus Hormones; Time Factors

Kept under medical surveillance were 120 patients with duodenal ulcer running an uncomplicated course. All patients and 30 healthy donors were studied for the status of the immunity T-system by spontaneous E-rosette formation (E-RFC) and availability of theophylline-resistant (TPP-RFC) and theophylline-sensitive (TPS-RFC) lymphocytes. With B-system being studied by FAC-rosette formation. All patients with duodenal ulcer displayed a decline in the content of E-RFC, TFP-RFC, TFS-RFC as compared to the indices in controls. Inclusion into the combined therapy of thymalin and dalargin was noted to be associated with a positive dynamics in the rise of T-lymphocytes, their subpopulations to the level in controls, percentage of TFS-RFC. Indices for TFS-RFC did not differ from control ones either before or after the treatment.

Topics: Adjuvants, Immunologic; Adolescent; Adult; Aged; B-Lymphocyte Subsets; Chronic Disease; Drug Evaluation; Duodenal Ulcer; Enkephalin, Leucine-2-Alanine; Female; Humans; Male; Middle Aged; T-Lymphocyte Subsets; Thymus Hormones

When examined for immunological status, complement, basic endogenic protease blockers parameters, patients with infiltrative destructive tuberculosis of the lungs (IDTL) and IDTL combination with exacerbation of chronic pyo-inflammatory bronchitis, exhibited disturbances in cellular and humoral immunity, complement activity, content of alpha 1 protease inhibitor and alpha 2 macroglobulin which aggravated in combined respiratory pathology. Nonspecific aerosol treatment with native protease inhibitors (contrykal or gordox) and thymalin aroused the efficacy of etiotropic treatment and promoted normalization of the above defense systems.

Topics: Adjuvants, Immunologic; Adult; Aerosols; Aprotinin; B-Lymphocytes; Bronchitis; Chronic Disease; Complement System Proteins; Humans; Immunoglobulins; Lung Diseases, Obstructive; Protease Inhibitors; T-Lymphocytes; Thymus Hormones; Trypsin Inhibitors; Tuberculosis, Pulmonary

Thymic serum activity (TSA) has been studied in 52 healthy subjects, 48 rheumatoid arthritis patients and 17 sufferers with systemic lupus erythematosus aged from 18 to 70. TSA was compared in patients under and over 40 years. In those under 40 TSA appeared significantly inhibited, while in older subjects it did not differ from age-matched control. No correlations were reported between TSA levels and clinical characteristics. Changes in TSA levels may be related both to low content of thymic hormones and formation of inactive complexes from thymic mediators with inhibitors.

Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Chronic Disease; Humans; Lupus Erythematosus, Systemic; Middle Aged; Thymic Factor, Circulating

Topics: Adjuvants, Immunologic; Asthma; Chronic Disease; Drug Evaluation; Humans; Immune Tolerance; Prognosis; Remission Induction; Thymus Hormones; Time Factors

Topics: Adjuvants, Immunologic; Chronic Disease; Drug Evaluation; Hepatitis; Hepatitis B; Hepatitis, Chronic; Humans; Liver Cirrhosis; Liver Diseases; Peptides; Thymus Extracts; Thymus Hormones

Changes in primordial lymphoid organs (bone marrow and thymus) with respect to the content of a serum thymic factor in the blood and specific activity of end desoxynucleotidyltransferase in the bone marrow and peripheral blood were studied in patients with chronic glomerulonephritis with and without the nephrotic syndrome. The mechanisms of autoimmunization were also studied with respect to the presence of renal tissue autoantigen antibodies. Alteration of primordial lymphoid organs was not attended by the autoimmune changes, i.e. production of the renal autoantigen antibodies was not increased. This makes difficult interpretation of the nephrotic syndrome as an autoimmune process and of glomerulonephritis as a whole. Lymphocytes bearing end desoxynucleotidyltransferase more probably participate in the developmental mechanisms of chronic glomerulonephritis.

Topics: Bone Marrow; Cell Differentiation; Chronic Disease; DNA Nucleotidylexotransferase; Female; Glomerulonephritis; Hematopoietic Stem Cells; Humans; Lymphocytes; Male; Thymic Factor, Circulating; Thymus Gland

Topics: Adjuvants, Immunologic; Adolescent; Adult; Chronic Disease; Duodenitis; Female; Gastritis; Humans; Immunity, Cellular; Levamisole; Male; Peptic Ulcer; Thymus Hormones

Topics: Adjuvants, Immunologic; Child; Chronic Disease; Genetic Carrier Screening; Hepatitis B; Hepatitis, Chronic; Homozygote; Humans; Levamisole; Thymus Hormones

Topics: Adjuvants, Immunologic; Adolescent; Adult; Antibody Formation; Chronic Disease; Drug Evaluation; Humans; Immunity, Cellular; Middle Aged; Skin Diseases; Thymus Hormones

The work deals with the results of the study of T-lymphocytes and their subpopulations (active, thermostable, theophylline-sensitive and theophylline-resistant) in 102 children with chronic viral hepatitis B, depending on the effectiveness of thymalin therapy. The sensitization of lymphocytes to specific antigens was studied. Among patients with chronic viral hepatitis B and cirrhosis of the liver the homozygous phenotype of haptoglobin is registered essentially more frequently (63.6% and 82.4% respectively) than among healthy persons (44.0%). The patients of this group showed a decrease in the number of T-lymphocytes, disturbances in the suppressor/helper ratio: hypersuppression in persisting hepatitis and hyposuppression in active hepatitis. In 71.6% of cases thymalin therapy produced an effect manifested by clinico-biochemical remission, an increase in the number of T-lymphocytes, thermostable cells and the normalization of the T-suppressor/T-helper ratio. In these patients sensitization to HBsAg essentially decreased (from 30.5% to 13.9%), while sensitization to human liver lipoprotein retained its high level even after treatment with thymalin.

Topics: Adjuvants, Immunologic; Adolescent; Child; Child, Preschool; Chronic Disease; Haptoglobins; Hepatitis B; Hepatitis B Surface Antigens; Humans; Immunologic Deficiency Syndromes; Phenotype; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thymus Hormones

Topics: Adjuvants, Immunologic; Child; Chronic Disease; Drug Evaluation; Female; Hepatitis B; Humans; Male; T-Lymphocytes; Thymus Hormones

Topics: Adjuvants, Immunologic; Child; Child, Preschool; Chronic Disease; Hepatitis B; Humans; Leukocyte Count; Lymphopenia; T-Lymphocytes; Thymus Hormones

Topics: Adjuvants, Immunologic; Adolescent; Adult; Antibody Formation; Chronic Disease; Drug Therapy, Combination; Female; Glomerulonephritis; Hemostasis; Humans; Hypertension; Immunity, Cellular; Kidney Failure, Chronic; Male; Middle Aged; Nephrotic Syndrome; Thymus Hormones

Ninety-eight patients with different patterns of chronic nonspecific pulmonary diseases (CNPD) were examined for thymus-dependent immunity. The clinical manifestations of T lymphocyte dysfunction included a torpid recurrent inflammatory process in the respiratory system, respiratory viral infections, short-term efficacy of antibacterial drugs. The patients demonstrated a decrease in the number of T lymphocytes, in production of immune interferon, and in secretion of serum thymic humoral factor. Application of tactivin, a new immunomodulator, is an effective approach to correction of the disorders enumerated. The drug has a beneficial effect on inflammatory process, reduces the symptoms of virus-induced intoxication. Administration of repeated tactivin treatment made it possible to shorten the time of repeated tactivin treatment made it possible to shorten the time of staying at hospital, to reduce the frequency of CNPD relapses from 80 to 36% within the period from 2 months to 1.5 years. This permits recommending the drug during resistance to antibiotic therapy.

Topics: Adjuvants, Immunologic; Adolescent; Adult; Chronic Disease; Combined Modality Therapy; Drug Evaluation; Female; Humans; Immunity, Cellular; Immunologic Deficiency Syndromes; Interferon Type I; Leukocyte Count; Lung Diseases; Lymphocyte Activation; Male; Middle Aged; Peptides; T-Lymphocytes; Thymic Factor, Circulating; Thymus Extracts