thymic-factor--circulating has been researched along with Cell-Transformation--Neoplastic* in 2 studies
2 other study(ies) available for thymic-factor--circulating and Cell-Transformation--Neoplastic
Article | Year |
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Studies of the thymus in mice bearing the Lewis lung carcinoma. II. Modulation of thymic natural killer activity by thymulin (FTS-Zn) and the antimetastatic effect of zinc.
Modulation of thymic natural killer (NK) cell activity by the serum thymic factor (thymulin or FTS-Zn) was demonstrated in mice carrying the Lewis lung carcinoma (3LL). Thymulin decreased the increased NK activity found in amputated (tumor) tumor-bearing mice and induced a significant NK activity in nonamputated mice, normally devoid of such activity. Zinc had no effect in either case. Histological studies revealed that zinc prevented the tumor-induced thymic atrophy. A clear-cut decrease in the number of lung metastases was observed in zinc-treated mice. This effect was suppressed by concomitant administration of thymulin to amputated mice. The thymic dependency of the anti-metastatic action of zinc as well as the mode of action of thymulin on NK cell activity in tumor-bearing animals is discussed. Topics: Animals; Cell Transformation, Neoplastic; Cytotoxicity, Immunologic; Female; Killer Cells, Natural; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Organ Size; Thymectomy; Thymic Factor, Circulating; Thymus Gland; Thymus Hormones; Zinc | 1983 |
T-cell differentiating activity in tissue cultures containing mycosis fungoides epidermal cells.
Topics: Cell Transformation, Neoplastic; Culture Techniques; Epidermis; Humans; Mycosis Fungoides; Skin Neoplasms; T-Lymphocytes; Thymic Factor, Circulating; Thymus Hormones | 1980 |