thymic-factor--circulating and Candidiasis

27 patients with chronic candidiasis of the skin and mucous membranes have been examined with a view to study the expression of E-receptors and its changes after the incubation of T-lymphocytes with theophylline, levamisole, thymaline and Candida albicans antigen. This study has revealed that, in comparison with healthy persons, most patients show decreased expression of E-receptors, and the character of their changes after incubation with the above-mentioned preparations is essentially different. The deviations revealed in this study have been regarded as the modification of T-cell membranes, which is seemingly one of the reasons of the weak competence of T-cells. In its turn, the expression of E-receptors may be considered as an indicator of the influence of different factors on T-lymphocytes. Substances altering the level of cyclic nucleotides in the cell, the antigenic fractions of the fungal causative agent, the suppression or blocking the action of thymic hormone-like substances may serve as such factors.

Topics: Adjuvants, Immunologic; Adolescent; Adult; Antigens, Fungal; Candida albicans; Candidiasis; Candidiasis, Chronic Mucocutaneous; Child; Child, Preschool; Humans; Leukocyte Count; Levamisole; Receptors, Immunologic; Rosette Formation; Surface Properties; T-Lymphocytes; Theophylline; Thymus Hormones