thymic-factor--circulating and Angina-Pectoris

The effect of the thymus polypeptide factor-thymidin on the lipid spectrum of the blood, thymic factor content in the blood and clinical course of the disease were studied in 156 patients with exertion stenocardia (II-IV functional class). Results indicate that patients with exertion stenocardia show with advance of the disease a reduction of the blood thymic factor and 85.6% develop hyperlipidemia. Complex treatment with inclusion of thymalin resulted in an increase of the thymic factor, normalization of the lipid metabolism increase of the contractile function of the myocardium and, thus, increases the treatment efficacy.

Topics: Adjuvants, Immunologic; Adult; Angina Pectoris; Combined Modality Therapy; Drug Evaluation; Female; Humans; Lipids; Male; Middle Aged; Myocardial Ischemia; Physical Exertion; Thymus Hormones

Using immunological and biochemical methods, the existence was proved of a relationship between atherogenous types of hyperlipoproteinaemia and decrease of the functional activity of the T-component of the immune system in patients with ischaemic heart disease. In IHD patients without lipid metabolism disturbances the indicators of the functional activity of the thymus-dependent factor of the immune system were reduced to a much lesser extent. The results stress the role of thymus-dependent factors and lipids in the development of ischaemic heart disease.

Topics: Adult; Angina Pectoris; Coronary Disease; Humans; Hyperlipoproteinemias; Hypertension; Immune Tolerance; Male; Middle Aged; Myocardial Infarction; T-Lymphocytes; Thymic Factor, Circulating