thymic-factor--circulating and Acute-Disease

The study was aimed to research levels of main acute inflammation phase peptides, coagulative and fibrinolitic plasma activity on the background of traditional treatment and with addition of Timalin in patients with acute lung abscess. The study demonstrated that induction of bioregulative therapy leads to faster normalization of main indicators of SIRS and plasma fibrinolitic activity and eliminates hypercoagulation.

Topics: Acute Disease; Acute-Phase Proteins; Adjuvants, Immunologic; Adult; Anti-Bacterial Agents; Biomarkers; Blood Coagulation Tests; Combined Modality Therapy; Disseminated Intravascular Coagulation; Female; Humans; Immunomodulation; Lung; Lung Abscess; Male; Pneumonectomy; Systemic Inflammatory Response Syndrome; Thymus Hormones; Treatment Outcome

Analysis of immune and enzyme disorders in 85 patients with acute pancreatitis shows that persistent imbalance of immunoregulatory T-lymphocytes with suppression predominance; reduction of all immunoglobulines number, imbalance in phagocytic immunity with height of absorbing activity of neutropils and stimultaneous decrease of their digestive capacity are prognostically unfavourable for high risk of pyonecrotic complications and lethal outcome. It is necessary to include immunocorrectors in combined therapy. Direct assessment of leukocytic elastase activity and alpha-IP level in blood plasma permits to evaluate spreading of inflammatory process and it severity, efficacy and prognosis of treatment.

Topics: Acute Disease; Adjuvants, Immunologic; Adult; Aged; Anti-Bacterial Agents; Clinical Enzyme Tests; Humans; Immunoglobulins; Leukocytes; Middle Aged; Neutrophils; Pancreatitis; Phagocytes; Prognosis; Risk Factors; T-Lymphocytes; Thymus Hormones; Time Factors

Topics: Acute Disease; Child; Child, Preschool; Combined Modality Therapy; Dermatitis, Atopic; Desensitization, Immunologic; Humans; Immunosuppressive Agents; Levamisole; Respiratory Hypersensitivity; Thymus Hormones; Virus Diseases

The content of the thymalin polypeptides in the thymus is studied in the course of the 1st to 4th stages of the acute thymus involution in children dying from noninfectious and infectious disease. The results obtained were compared to the level of the circulating thymic factor and the number of T- and 'O' lymphocytes in the circulating blood of children with identical diseases and control group of the same age. It is concluded that the acute involution of the thymus in children with non-infectious and acute infectious diseases results in the progressive decrease of the production by the thymus of the immunomodulating polypeptides (thymic hormones) which is restored in the period of recovery.

Topics: Acute Disease; Adjuvants, Immunologic; Communicable Diseases; Humans; Infant; Infant, Newborn; Leukocyte Count; Peptides; Thymic Factor, Circulating; Thymus Gland

Nonspecific adhesiveness of lymphocytes to polyacrylonitrile fiber and the antigen-specific adhesiveness of T-lymphocytes to Shigella flexneri pellicular immunosorbent have been studied in dysentery patients. Short courses of treatment with indomethacin, but not with thymalin (the preparation of thymic hormones), used for immunomodulation, have accelerated the normalization of nonspecific lymphocyte adhesiveness during regression of the disease, while indomethacin, in contrast to thymalin, inhibits antigen-specific T-lymphocyte adhesiveness which increases with the development of immune response.

Topics: Acute Disease; Adjuvants, Immunologic; Adult; Antigens, Bacterial; Combined Modality Therapy; Convalescence; Dysentery, Bacillary; Epitopes; Humans; Immunity, Innate; Immunosorbent Techniques; Indomethacin; Lymphocytes; Middle Aged; Shigella flexneri; Thymus Hormones

Topics: Acute Disease; Adjuvants, Immunologic; Adolescent; Adult; Combined Modality Therapy; Drug Evaluation; Dysentery, Bacillary; Humans; Intestinal Diseases; Male; Shigella flexneri; Shigella sonnei; Thymus Hormones; Typhoid Fever

Results of the investigation of parameters of cell and humoral immunity and coagulogram in 63 patients with acute peritonitis have shown that thymalin when used solely or in combination with heparin facilitates quicker arrest of the pathological process, its clinical and laboratory symptoms. The combination of thymalin and heparin is indicated to elderly patients and in cases with higher risk of thromboformation.

Topics: Acute Disease; Adjuvants, Immunologic; Adolescent; Adult; Aged; Antibody Formation; Blood Coagulation; Drug Evaluation; Drug Therapy, Combination; Female; Heparin; Humans; Immunity, Cellular; Male; Middle Aged; Peritonitis; Postoperative Care; Thymus Hormones

Topics: Acute Disease; Humans; Infant; Infant, Newborn; Reference Values; Respiratory Tract Infections; Thymic Factor, Circulating; Thymus Hormones; Thymus Hyperplasia; Virus Diseases

Lymphocyte subpopulations were determined in 13 patients, recipients of kidney allografts, 7 of them during an acute rejection episode (ARE). Monitoring of the T lymphocyte suppressor or T helper cells was performed by aid of the theophylline sensitivity test and the local xenogeneic graft-versus-host reaction (GVHR). An absence or a striking decrease of theophylline-sensitive T suppressor cells was found in all patients during ARE. Incubation of the lymphocytes of these patients with a thymic hormone, THF, raised the number of TS lymphocytes from nil or from a very low level to normal or above. The therapeutic use of THF in selected renal allograft recipients is proposed.

Topics: Acute Disease; Adolescent; Adult; Female; Graft Rejection; Graft vs Host Reaction; Humans; Kidney Transplantation; Leukocyte Count; Male; T-Lymphocytes, Regulatory; Theophylline; Thymic Factor, Circulating; Thymus Hormones

Topics: Acute Disease; Antibody Formation; Child, Preschool; Humans; Immunity, Cellular; Infant; Pneumonia, Pneumococcal; Thymus Extracts; Thymus Hormones