thromboxane-b2 and Uveitis--Posterior

thromboxane-b2 has been researched along with Uveitis--Posterior* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-b2 and Uveitis--Posterior

Article	Year
Treatment of S antigen uveoretinitis with lipoxygenase and cyclo-oxygenase inhibitors. Ophthalmic research, 1991, Volume: 23, Issue:2 The role of metabolites of arachidonic acid (AA) in experimental autoimmune uveoretinitis was studied using inhibitors of AA metabolism. Nordihydroguaiaretic acid (NDGA), which inhibits predominantly the lipoxygenase (LO) pathway, or indomethacin, a specific cyclo-oxygenase (CO) inhibitor, was administered to rats immunized with retinal S antigen. Levels of various AA metabolites were measured in the inflamed uvea, and the severity of intraocular inflammation was quantitated by morphometric analysis. Histopathologically, the uveoretinitis was significantly suppressed following treatment with NDGA, while indomethacin treatment resulted in augmentation of the disease (p less than 0.05). These results tend to indicate that the inhibition of the LO rather than the CO pathway may be more beneficial in the treatment of autoimmune uveitis. Topics: Animals; Anthropometry; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arrestin; Dinoprostone; Disease Models, Animal; Eye Proteins; Female; Indomethacin; Leukotriene B4; Masoprocol; Radioimmunoassay; Rats; Rats, Inbred Lew; Retinitis; Thromboxane B2; Uveitis, Posterior	1991

Article

Year

Treatment of S antigen uveoretinitis with lipoxygenase and cyclo-oxygenase inhibitors.

Ophthalmic research, 1991, Volume: 23, Issue:2

The role of metabolites of arachidonic acid (AA) in experimental autoimmune uveoretinitis was studied using inhibitors of AA metabolism. Nordihydroguaiaretic acid (NDGA), which inhibits predominantly the lipoxygenase (LO) pathway, or indomethacin, a specific cyclo-oxygenase (CO) inhibitor, was administered to rats immunized with retinal S antigen. Levels of various AA metabolites were measured in the inflamed uvea, and the severity of intraocular inflammation was quantitated by morphometric analysis. Histopathologically, the uveoretinitis was significantly suppressed following treatment with NDGA, while indomethacin treatment resulted in augmentation of the disease (p less than 0.05). These results tend to indicate that the inhibition of the LO rather than the CO pathway may be more beneficial in the treatment of autoimmune uveitis.

Topics: Animals; Anthropometry; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arrestin; Dinoprostone; Disease Models, Animal; Eye Proteins; Female; Indomethacin; Leukotriene B4; Masoprocol; Radioimmunoassay; Rats; Rats, Inbred Lew; Retinitis; Thromboxane B2; Uveitis, Posterior

1991