thromboxane-b2 and Rhinitis--Allergic--Seasonal

thromboxane-b2 has been researched along with Rhinitis--Allergic--Seasonal* in 2 studies

Other Studies

2 other study(ies) available for thromboxane-b2 and Rhinitis--Allergic--Seasonal

Article	Year
Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Thrombosis and haemostasis, 1986, Dec-15, Volume: 56, Issue:3 In a case control study 31 asymptomatic patients with asthma and/or hay fever and 31 normal controls had their bleeding time measured using the Simplate II device and venostasis. Mean bleeding time in the atopic group (527 s) was significantly prolonged compared to the controls (393 s) (p less than 0.0005). Platelet aggregation to collagen and ADP (but not to PAF-acether) was significantly depressed in the atopics. Mean circulating platelet mass was significantly greater in atopics than in the controls (p = 0.006). Stepwise multiple regression analysis showed that within the control group bleeding time was best predicted by platelet mass (p = 0.007). No such relationship was found in the atopics. However stepwise multiple regression analysis showed that bleeding time in the atopics (but not in the controls) was best predicted by PAF-acether induced platelet aggregability (p less than 0.05). In neither group was bleeding time related to collagen induced platelet thromboxane B2 production. It is hypothesised that in respiratory atopy the depressed aggregatory function of platelets is not compensated for sufficiently by an increase in platelet mass, leading to prolongation of the bleeding time. This haemostatic imbalance, whose cause remains to be established, appears to constitute a trait of atopy. Topics: Adenosine Diphosphate; Adult; Asthma; Bleeding Time; Collagen; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Platelet Function Tests; Rhinitis, Allergic, Seasonal; Thromboxane B2	1986
Mediator studies in skin blister fluid from patients with dual skin reactions after intradermal allergen injection. The Journal of allergy and clinical immunology, 1982, Volume: 70, Issue:4 Skin blister fluid (SBF) samples obtained after allergen skin testing in a total of 26 patients with late cutaneous reactions (LCRs) were examined for the presence of various vasoactive mediators. Histamine was predominant during the early phase of the wheal and flare reaction(206 +/- 40 ng/ml) and decreased with the development of the LCR toward normal SBF levels (around 20 ng/ml). Kallikrein activity was measurable in low amounts (around 5 ng/ml) in three out of 13 SBF samples taken 30 min after skin testing and in five of 13 SBF samples taken 6 hr after allergen testing. The thromboxane B2 content of SBF showed an increase with the development of LCR (control skin 976 +/- 483 ng/ml; allergen-tested skin 30 min after allergen injection, 1465 +/- 1566 ng/ml; allergen-tested skin 6 hr after antigen injection, 1775 +/- 731 ng/ml). SBF obtained from normal skin as well as from allergen-tested skin showed significant platelet-activating property as measured in an in vitro serotonin-release assay from washed human platelets. It is concluded that during the development of late-phase reactions a complex interaction of various mediator systems takes place. Topics: Adolescent; Adult; Allergens; Animals; Asthma; Blister; Child; Female; Histamine Release; Humans; Hypersensitivity, Immediate; Intradermal Tests; Kallikreins; Male; Rats; Rhinitis, Allergic, Seasonal; Serotonin; Skin; Skin Tests; Thromboxane B2	1982

Article

Year

Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever.

Thrombosis and haemostasis, 1986, Dec-15, Volume: 56, Issue:3

In a case control study 31 asymptomatic patients with asthma and/or hay fever and 31 normal controls had their bleeding time measured using the Simplate II device and venostasis. Mean bleeding time in the atopic group (527 s) was significantly prolonged compared to the controls (393 s) (p less than 0.0005). Platelet aggregation to collagen and ADP (but not to PAF-acether) was significantly depressed in the atopics. Mean circulating platelet mass was significantly greater in atopics than in the controls (p = 0.006). Stepwise multiple regression analysis showed that within the control group bleeding time was best predicted by platelet mass (p = 0.007). No such relationship was found in the atopics. However stepwise multiple regression analysis showed that bleeding time in the atopics (but not in the controls) was best predicted by PAF-acether induced platelet aggregability (p less than 0.05). In neither group was bleeding time related to collagen induced platelet thromboxane B2 production. It is hypothesised that in respiratory atopy the depressed aggregatory function of platelets is not compensated for sufficiently by an increase in platelet mass, leading to prolongation of the bleeding time. This haemostatic imbalance, whose cause remains to be established, appears to constitute a trait of atopy.

Topics: Adenosine Diphosphate; Adult; Asthma; Bleeding Time; Collagen; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Platelet Function Tests; Rhinitis, Allergic, Seasonal; Thromboxane B2

1986

Mediator studies in skin blister fluid from patients with dual skin reactions after intradermal allergen injection.

The Journal of allergy and clinical immunology, 1982, Volume: 70, Issue:4

Skin blister fluid (SBF) samples obtained after allergen skin testing in a total of 26 patients with late cutaneous reactions (LCRs) were examined for the presence of various vasoactive mediators. Histamine was predominant during the early phase of the wheal and flare reaction(206 +/- 40 ng/ml) and decreased with the development of the LCR toward normal SBF levels (around 20 ng/ml). Kallikrein activity was measurable in low amounts (around 5 ng/ml) in three out of 13 SBF samples taken 30 min after skin testing and in five of 13 SBF samples taken 6 hr after allergen testing. The thromboxane B2 content of SBF showed an increase with the development of LCR (control skin 976 +/- 483 ng/ml; allergen-tested skin 30 min after allergen injection, 1465 +/- 1566 ng/ml; allergen-tested skin 6 hr after antigen injection, 1775 +/- 731 ng/ml). SBF obtained from normal skin as well as from allergen-tested skin showed significant platelet-activating property as measured in an in vitro serotonin-release assay from washed human platelets. It is concluded that during the development of late-phase reactions a complex interaction of various mediator systems takes place.

Topics: Adolescent; Adult; Allergens; Animals; Asthma; Blister; Child; Female; Histamine Release; Humans; Hypersensitivity, Immediate; Intradermal Tests; Kallikreins; Male; Rats; Rhinitis, Allergic, Seasonal; Serotonin; Skin; Skin Tests; Thromboxane B2

1982