thromboxane-b2 and Kidney-Calculi

thromboxane-b2 has been researched along with Kidney-Calculi* in 2 studies

Other Studies

2 other study(ies) available for thromboxane-b2 and Kidney-Calculi

Article	Year
Extracorporeal shock wave lithotripsy induces the release of prostaglandins which increase ureteric peristalsis. British journal of urology, 1993, Volume: 71, Issue:6 The aim of this study was to identify the changes in secretion of prostaglandins into the urinary tract as a result of treatment by extracorporeal shock wave lithotripsy (ESWL) and to determine their effects on ureteric motility. Sixteen patients with renal or upper ureteric calculi were studied. A peripheral blood and urine sample was collected immediately before and after ESWL, with further samples taken 24 h later. The following variables were assessed by radioimmunoassay:prostaglandin E2 (PGE2), prostaglandin F1 alpha (PGF1 alpha), and thromboxane B2 (TXB2). An in vitro canine study was then designed to study the activity of TXB2, PGF1 alpha and PGE2 on an isolated intact canine ureter model. Significant elevations of TXB2 were found immediately after ESWL in both serum and urine, which fell almost to pre-treatment levels by 24 h. PGF1 alpha levels showed significant elevations at 24 h but no immediate increase as seen with TXB2. In contrast, PGE2 levels were unchanged in the urine but significantly decreased in the serum. In vitro studies showed that both TXB2 and PGF1 alpha repeatedly produced an increased frequency of ureteric contraction. ESWL results in the release of prostaglandins from the urinary tract which are shown to cause increased ureteric peristalsis. Topics: Adult; Animals; Culture Techniques; Dinoprostone; Dogs; Female; Humans; Kidney Calculi; Lithotripsy; Male; Muscle Contraction; Prostaglandins F; Thromboxane B2; Ureter; Ureteral Calculi	1993
[Obstructive nephropathy; kidney function and renal excretion of prostaglandin (E)2 and Thromboxane B(2) following percutaneous decompression nephropyelostomy]. Der Urologe. Ausg. A, 1988, Volume: 27, Issue:5 In patients with chronic urinary obstruction the excretion of prostaglandin E(2) (PGE2) and thromboxane B(2) (TXB2) was measured. During obstruction signs of an increased vasoconstrictor (TXB2)- and a decreased vasodilator (PGE2) activity were found. After percutaneous nephropyelostomy a reverse pattern with decrease of the initially high (TXB2) excretion and increase of the PGE(2)excretion was observed. It is suggested that these changes of the arachidonic acid metabolism previously found in animals also take part in the pathophysiological changes in humans after relief of urinary obstruction having significant effect of renal blood flow, glomerular filtration rate and tubular function in obstructive nephropathy in humans. Topics: Adult; Dinoprostone; Female; Humans; Hydronephrosis; Kidney Calculi; Male; Middle Aged; Nephrostomy, Percutaneous; Prostatic Neoplasms; Thromboxane B2; Tissue Adhesions; Ureteral Obstruction	1988

Article

Year

Extracorporeal shock wave lithotripsy induces the release of prostaglandins which increase ureteric peristalsis.

British journal of urology, 1993, Volume: 71, Issue:6

The aim of this study was to identify the changes in secretion of prostaglandins into the urinary tract as a result of treatment by extracorporeal shock wave lithotripsy (ESWL) and to determine their effects on ureteric motility. Sixteen patients with renal or upper ureteric calculi were studied. A peripheral blood and urine sample was collected immediately before and after ESWL, with further samples taken 24 h later. The following variables were assessed by radioimmunoassay:prostaglandin E2 (PGE2), prostaglandin F1 alpha (PGF1 alpha), and thromboxane B2 (TXB2). An in vitro canine study was then designed to study the activity of TXB2, PGF1 alpha and PGE2 on an isolated intact canine ureter model. Significant elevations of TXB2 were found immediately after ESWL in both serum and urine, which fell almost to pre-treatment levels by 24 h. PGF1 alpha levels showed significant elevations at 24 h but no immediate increase as seen with TXB2. In contrast, PGE2 levels were unchanged in the urine but significantly decreased in the serum. In vitro studies showed that both TXB2 and PGF1 alpha repeatedly produced an increased frequency of ureteric contraction. ESWL results in the release of prostaglandins from the urinary tract which are shown to cause increased ureteric peristalsis.

Topics: Adult; Animals; Culture Techniques; Dinoprostone; Dogs; Female; Humans; Kidney Calculi; Lithotripsy; Male; Muscle Contraction; Prostaglandins F; Thromboxane B2; Ureter; Ureteral Calculi

1993

[Obstructive nephropathy; kidney function and renal excretion of prostaglandin (E)2 and Thromboxane B(2) following percutaneous decompression nephropyelostomy].

Der Urologe. Ausg. A, 1988, Volume: 27, Issue:5

In patients with chronic urinary obstruction the excretion of prostaglandin E(2) (PGE2) and thromboxane B(2) (TXB2) was measured. During obstruction signs of an increased vasoconstrictor (TXB2)- and a decreased vasodilator (PGE2) activity were found. After percutaneous nephropyelostomy a reverse pattern with decrease of the initially high (TXB2) excretion and increase of the PGE(2)excretion was observed. It is suggested that these changes of the arachidonic acid metabolism previously found in animals also take part in the pathophysiological changes in humans after relief of urinary obstruction having significant effect of renal blood flow, glomerular filtration rate and tubular function in obstructive nephropathy in humans.

Topics: Adult; Dinoprostone; Female; Humans; Hydronephrosis; Kidney Calculi; Male; Middle Aged; Nephrostomy, Percutaneous; Prostatic Neoplasms; Thromboxane B2; Tissue Adhesions; Ureteral Obstruction

1988