thromboxane-b2 has been researched along with Glucose-Intolerance* in 2 studies
2 other study(ies) available for thromboxane-b2 and Glucose-Intolerance
| Article | Year |
|---|---|
Structural, functional and circulatory placental changes associated with impaired glucose metabolism.
To investigate associations between structural, functional and circulatory placental changes in pregnancies complicated by impaired glucose metabolism.. Umbilical artery (UA) blood flow resistance was measured by Doppler velocimetry in 21 gravidae with diabetes/impaired glucose tolerance (IGT) and 10 healthy gravidae. Umbilical and placental vessel segments were incubated for determination of prostacyclin and thromboxane synthesis, and tissues histologically examined. Non-parametric statistical tests at a two-tailed P<0.05 were used.. Placental lesions were more common in diabetes/IGT and, although not being an uniform finding, in general associated with a higher vascular synthesis of thromboxane and/or lower prostacyclin/thromboxane synthesis ratio. As an exception, ischemic villitis was associated with a higher ratio and higher UA flow resistance.. Placental lesions are associated with an altered vascular prostanoid synthesis in diabetes/IGT, but not until structural signs of ischemia develop is a rise of UA blood flow resistance detected. Topics: 6-Ketoprostaglandin F1 alpha; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucose Intolerance; Humans; Infarction; Ischemia; Placenta; Placenta Diseases; Pregnancy; Pregnancy in Diabetics; Thrombosis; Thromboxane B2; Umbilical Arteries; Vascular Resistance | 2002 |
Signs of platelet activation, but not lipid peroxidation, in fetal blood associated with functional and structural umbilicoplacental lesions in pregnancies complicated by impaired glucose metabolism.
To study the influence of platelet activation and lipid peroxidation in fetal blood on umbilical vascular prostanoid synthesis and placental morphology in diabetic pregnancy.. The concentrations of thromboxane A2 (TxA2) and malondialdehyde (MDA) were determined in umbilical cord plasma in 21 women with diabetes mellitus/impaired glucose tolerance (DM/IGT) and ten healthy women. Segments from the umbilical artery and vein were incubated and prostacyclin (PGI2) and TxA2 metabolites were determined. Prostanoid synthesis was stimulated with calcium ionophore at a second incubation. Histological examination was carried out in samples from the umbilical cord, membranes and placental parenchyma. Non-parametric statistical analysis was used, with a two-tailed p < 0.05 considered statistically significant.. Cord plasma TxA2, but not MDA, was higher among DM/IGT women (p = 0.07). There were indications that cord plasma TxA2, but not MDA, was positively correlated with vascular prostanoid synthesis and synthesis capacity. In the umbilical vein, both the basal and stimulated PGI2 production and the stimulated TxA2 production were lower in the DM/IGT group. Ischemic placental lesions were associated with a high TxA, and a low MDA concentration in cord plasma.. Even in less severe forms of impaired glucose metabolism, disturbances in platelet activation significantly affect both biochemical and morphological vessel wall and tissue functions in the umbilicoplacental unit. This could indicate an abnormal programming of fetal cell functions and designate cases at increased risk of developing cellular and organ damage. Topics: 6-Ketoprostaglandin F1 alpha; C-Peptide; Embryonic and Fetal Development; Epoprostenol; Female; Fetal Blood; Glucose Intolerance; Glycated Hemoglobin; Humans; Lipid Peroxidation; Malondialdehyde; Placenta; Placenta Diseases; Platelet Activation; Pregnancy; Pregnancy in Diabetics; Thromboxane A2; Thromboxane B2; Umbilical Arteries; Umbilical Veins | 2002 |