thromboxane-b2 has been researched along with Ear-Diseases* in 2 studies
2 other study(ies) available for thromboxane-b2 and Ear-Diseases
| Article | Year |
|---|---|
6-Deoxy- and 11-Hydroxytolypodiols: Meroterpenoids from the Cyanobacterium HT-58-2.
Chemical investigation of cyanobacterial strain HT-58-2, which most closely aligns with the genus Topics: Animals; Anti-Inflammatory Agents; Cyanobacteria; Diterpenes; Ear Diseases; Edema; Escherichia coli; Lipopolysaccharides; Mice; Rats; Superoxides; Thromboxane B2 | 2020 |
Suppressive effect of 2-phenyl-4-quinolone (YT-1) on hind-paw edema and cutaneous vascular plasma extravasation in mice.
Like indomethacin, BW755C, diphenhydramine and methysergide, 2-phenyl-4-quinolone (YT-1) suppressed the polymyxin B-induced hind-paw edema. This inhibitory effect of YT-1 was also demonstrated in adrenalectomized mice. YT-1 inhibited the antidromic stimulation of saphenous nerve-induced plasma leakage in dorsal paw skin and reduced the volume of plasma exudation in PCA reaction. Bradykinin-, substance P- and compound 48/80-induced mouse ear edema was suppressed by YT-1 in a dose-dependent manner. In isolated rat peritoneal mast cells, YT-1 produced a dose-dependent inhibition of bradykinin-, substance P- and compound 48/80-induced histamine and beta-glucuronidase release. YT-1 also reduced the TXB2 formation from PMN leukocytes with IC50 2.0 +/- 0.5 microM, however with little effect on LTB4 formation. Histamine- and serotonin-induced plasma exudation in ear edema were reduced by YT-1. Moreover, the maximal response of ileum contraction caused by histamine and serotonin were also suppressed by YT-1 in a dose-dependent manner. In compound 48/80-pretreatment mice, YT-1 failed to suppress the bradykinin- and substance P-induced ear edema to a significantly greater extent than diphenhydramine combined with methysergide did. These results indicate that the inhibitory effect of YT-1 on local edema formation is not through the release of steroid hormones from adrenal gland, and is probably by suppressing the release of chemical mediators from mast cells, inhibition of prostaglandins formation, and noncompetitive but selective protection of the vasculature against the histamine- and serotonin-induced plasma extravasation. Topics: Animals; Ear Diseases; Edema; Guinea Pigs; Hemorrhage; Hindlimb; Histamine; Ileum; In Vitro Techniques; Leukotriene B4; Mast Cells; Mice; Mice, Inbred ICR; Muscle Contraction; p-Methoxy-N-methylphenethylamine; Quinolones; Rats; Rats, Sprague-Dawley; Serotonin; Skin; Thromboxane B2 | 1994 |