thromboxane-b2 and Dermatitis--Atopic

In a double-blind trial patients with atopic eczema received either oral evening primrose oil (EPO) (n = 14) or placebo (n = 11) for 12 weeks. In the EPO group a statistically significant improvement was observed in the overall severity and grade of inflammation and in the percentage of the body surface involved by eczema as well as in dryness and itch. Patients in the placebo group showed a significant reduction in inflammation. The patients receiving EPO showed a significantly greater reduction in inflammation than those receiving placebo. Evening primrose oil caused a significant rise in the amount of dihomogammalinolenic acid in the plasma phospholipid fatty acids. Plasma levels of TXB2, 6-keto-PGF1 alpha and PGE1, and the amount of TXB2 released into serum during clotting were not altered by evening primrose oil.

Topics: 6-Ketoprostaglandin F1 alpha; Adult; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Dermatitis, Atopic; Dermatologic Agents; Double-Blind Method; Fatty Acids; Fatty Acids, Essential; Female; gamma-Linolenic Acid; Humans; Linoleic Acids; Male; Oenothera biennis; Phospholipids; Plant Oils; Random Allocation; Skin; Thromboxane B2

Column chromatography followed by RIA was used to measure the blood plasma content of arachidonic acid metabolites (leukotrienes C4, B4, C4/D4/E4, prostaglandins F2 alpha, E2, 6-keto-prostaglandin F1 alpha, thromboxane B2) in 146 children aged 6 months to 14 years with atopic dermatitis. The data obtained were compared to the healthy children's parameters. The majority of the patients manifested activation of the system of arachidonic acid metabolism. The intensity of changes in the content of eicosanoids was found to depend on the clinical pattern and spreading of skin lesions.

Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Arachidonic Acids; Child; Child, Preschool; Dermatitis, Atopic; Dinoprost; Dinoprostone; Humans; Infant; Leukotriene B4; SRS-A; Thromboxane B2

The blood plasma levels of a number of endogenous prostaglandins have been measured by column chromatography followed by radioimmunoassay in 33 patients with psoriasis and in 22 children with allergic dermatoses. The findings evidence an increase of these prostanoids at the peak of the skin process exacerbation, thus indicating their role in the pathogenesis of psoriasis and allergic dermatoses in children.

Topics: 6-Ketoprostaglandin F1 alpha; Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Dermatitis, Atopic; Humans; Infant; Middle Aged; Neurodermatitis; Psoriasis; Thromboxane B2