thromboxane-b2 and Cholecystitis--Acute

thromboxane-b2 has been researched along with Cholecystitis--Acute* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-b2 and Cholecystitis--Acute

Article	Year
Bile duct ligation induced acute inflammation up-regulates cyclooxygenase-2 content and PGE2 release in guinea pig gallbladder smooth muscle cell cultures. Prostaglandins, leukotrienes, and essential fatty acids, 2005, Volume: 72, Issue:5 This study examines hypotheses that BDL induces increased guinea pig gallbladder smooth muscle PGE2 release by up-regulation of COX-2.. BDL, Sham and Control Hartley guinea pig gallbladders were placed in cell culture, grown to confluence and underwent Western Blot analysis for smooth muscle cell content of COX-1, COX-2, Prostacylin Synthase, actin, caldesmon, vinculin, meta-vinculin and tropomyosin and were assayed for basal release of 6-keto-PGF(1alpha), PGE2 and TxB2 by EIA.. BDL did not alter content of smooth muscle cytoskeletal proteins. BDL for 48 h increased smooth muscle cell release of PGE2 and 6-keto-PGF(1alpha) by 3-fold or more when compared to the Control and Sham groups. Western Blot analysis showed increased content of COX-2 in the BDL group.. BDL for 48 h markedly increased endogenous guinea pig smooth muscle cell PG release, which was due to increased COX-2 synthesis. Topics: Animals; Bile Ducts; Cells, Cultured; Cholecystitis, Acute; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Gallbladder; Guinea Pigs; Inflammation; Ligation; Male; Myocytes, Smooth Muscle; Prostaglandin-Endoperoxide Synthases; Thromboxane B2; Up-Regulation	2005

Article

Year

Bile duct ligation induced acute inflammation up-regulates cyclooxygenase-2 content and PGE2 release in guinea pig gallbladder smooth muscle cell cultures.

Prostaglandins, leukotrienes, and essential fatty acids, 2005, Volume: 72, Issue:5

This study examines hypotheses that BDL induces increased guinea pig gallbladder smooth muscle PGE2 release by up-regulation of COX-2.. BDL, Sham and Control Hartley guinea pig gallbladders were placed in cell culture, grown to confluence and underwent Western Blot analysis for smooth muscle cell content of COX-1, COX-2, Prostacylin Synthase, actin, caldesmon, vinculin, meta-vinculin and tropomyosin and were assayed for basal release of 6-keto-PGF(1alpha), PGE2 and TxB2 by EIA.. BDL did not alter content of smooth muscle cytoskeletal proteins. BDL for 48 h increased smooth muscle cell release of PGE2 and 6-keto-PGF(1alpha) by 3-fold or more when compared to the Control and Sham groups. Western Blot analysis showed increased content of COX-2 in the BDL group.. BDL for 48 h markedly increased endogenous guinea pig smooth muscle cell PG release, which was due to increased COX-2 synthesis.

Topics: Animals; Bile Ducts; Cells, Cultured; Cholecystitis, Acute; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Gallbladder; Guinea Pigs; Inflammation; Ligation; Male; Myocytes, Smooth Muscle; Prostaglandin-Endoperoxide Synthases; Thromboxane B2; Up-Regulation

2005