thromboxane-b2 has been researched along with Ascorbic-Acid-Deficiency* in 1 studies
1 other study(ies) available for thromboxane-b2 and Ascorbic-Acid-Deficiency
| Article | Year |
|---|---|
Differential regulation of the formation of prostaglandins and related substances from arachidonic acid and from dihomogammalinolenic acid. II. Effects of vitamin C.
Vitamin C over the concentration range 10 to 100 microgram/ml (5.7-57 x 10-5 M) caused a dose dependent and highly significant enhancement of conversion of 14C-dihomogammalinolenic acid (DGLA) to prostaglandin (PG) E1 and to thromboxane (Tx) B1 by human platelets. Vitamin C had no effect on conversion of 14C-arachidonic acid to PGE2 and TxB2. The concentration range is relevant to physiology: in some cells which concentrate the vitamin, such as polymorphonbuclear leucocytes and the adrenal cortex, vitamin C concentrations may be substantially higher than 100 microgram/ml. Vitamin C can therefore selectively enhance the formation of cyclo-oxygenase generated products from DGLA without changing formation of those from AA. This effect can account for a number of the known actions of vitamin C including its effect on the immune system. The implications of this finding are discussed. Topics: 8,11,14-Eicosatrienoic Acid; Arachidonic Acids; Ascorbic Acid; Ascorbic Acid Deficiency; Blood Platelets; Fatty Acids, Unsaturated; Humans; In Vitro Techniques; Prostaglandins; Prostaglandins E; Thromboxane B2 | 1979 |