thromboxane-a2 and Tachycardia--Supraventricular

thromboxane-a2 has been researched along with Tachycardia--Supraventricular* in 1 studies

Trials

1 trial(s) available for thromboxane-a2 and Tachycardia--Supraventricular

Article	Year
Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia. Prostaglandins, leukotrienes, and essential fatty acids, 2006, Volume: 74, Issue:6 PSVT attack of >20min and frequency >160 is well-recognized model of myocardial dysfunction. We measured 6-keto-PGF1alpha and TXB(2) before and after adenosine administration to assess its cardioprotective potential. A total of 64 patients were randomly assigned as having acute episode of PSVT to adenosine or verapamil group. A bolus of 6mg of adenosine up to the maximum dose of 12 or 5mg of verapamil up to the maximum dose of 10mg were given, until the sinus rhythm was restored. The levels of PGI(2), TXA(2) and TAS were measured in three different time intervals. In adenosine group all parameters were normalized after 20min of conversion to sinus rhythm. The ratio of PGI(2)/TXA(2) increased after 5min of conversion to SR (P<0.01). Also, the ratio of TXA(2)/TAS was decreased for ADO (P<0.01). This is the first study to demonstrate that adenosine exerts cardioprotective effect. Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adult; Cardiotonic Agents; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Prostaglandins; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Thromboxane A2; Thromboxane B2; Verapamil	2006

Article

Year

Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia.

Prostaglandins, leukotrienes, and essential fatty acids, 2006, Volume: 74, Issue:6

PSVT attack of >20min and frequency >160 is well-recognized model of myocardial dysfunction. We measured 6-keto-PGF1alpha and TXB(2) before and after adenosine administration to assess its cardioprotective potential. A total of 64 patients were randomly assigned as having acute episode of PSVT to adenosine or verapamil group. A bolus of 6mg of adenosine up to the maximum dose of 12 or 5mg of verapamil up to the maximum dose of 10mg were given, until the sinus rhythm was restored. The levels of PGI(2), TXA(2) and TAS were measured in three different time intervals. In adenosine group all parameters were normalized after 20min of conversion to sinus rhythm. The ratio of PGI(2)/TXA(2) increased after 5min of conversion to SR (P<0.01). Also, the ratio of TXA(2)/TAS was decreased for ADO (P<0.01). This is the first study to demonstrate that adenosine exerts cardioprotective effect.

Topics: 6-Ketoprostaglandin F1 alpha; Adenosine; Adult; Cardiotonic Agents; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Prostaglandins; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Thromboxane A2; Thromboxane B2; Verapamil

2006