thromboxane-a2 and Preleukemia

thromboxane-a2 has been researched along with Preleukemia* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-a2 and Preleukemia

Article	Year
Thrombocytopathy in preleukaemia: association with a defect of thromboxane A2 activity. British journal of haematology, 1979, Volume: 41, Issue:3 Platelet aggregation and the platelet prostaglandin pathway have been investigated in two patients with preleukaemic states who had a haemorrhagic tendency but a normal platelet count. In both patients platelet aggregation induced by collagen adenosine diphosphate (ADP) and arachidonic acid (AA) were abnormal. Malonyldiadehyde (MDA) production from exogenous AA was normal in both patients thus excluding cyclo-oxygenase deficiency. The platelet aggregating and rabbit aorta contracting activities of thromboxane A2 (TxA2) were very low in both patients. Production of thromboxane B2 (TxB2) assessed by thin layer chromatographic separation of the metabolites of [1(-14)C]AA and by radioimmunoassay, was normal. These abnormalities of platelet function appear to be due to the production of TxA2 with a low biological activity. Topics: Adenine Nucleotides; Blood Platelet Disorders; Blood Platelets; Female; Humans; Male; Platelet Aggregation; Preleukemia; Thromboxane A2; Thromboxane B2; Thromboxanes	1979

Article

Year

Thrombocytopathy in preleukaemia: association with a defect of thromboxane A2 activity.

British journal of haematology, 1979, Volume: 41, Issue:3

Platelet aggregation and the platelet prostaglandin pathway have been investigated in two patients with preleukaemic states who had a haemorrhagic tendency but a normal platelet count. In both patients platelet aggregation induced by collagen adenosine diphosphate (ADP) and arachidonic acid (AA) were abnormal. Malonyldiadehyde (MDA) production from exogenous AA was normal in both patients thus excluding cyclo-oxygenase deficiency. The platelet aggregating and rabbit aorta contracting activities of thromboxane A2 (TxA2) were very low in both patients. Production of thromboxane B2 (TxB2) assessed by thin layer chromatographic separation of the metabolites of [1(-14)C]AA and by radioimmunoassay, was normal. These abnormalities of platelet function appear to be due to the production of TxA2 with a low biological activity.

Topics: Adenine Nucleotides; Blood Platelet Disorders; Blood Platelets; Female; Humans; Male; Platelet Aggregation; Preleukemia; Thromboxane A2; Thromboxane B2; Thromboxanes

1979