thromboxane-a2 and Nephrosis--Lipoid

thromboxane-a2 has been researched along with Nephrosis--Lipoid* in 2 studies

Other Studies

2 other study(ies) available for thromboxane-a2 and Nephrosis--Lipoid

Article	Year
[The effect of peripheral blood mononuclear cell products from children with nephrotic syndrome on thromboxane A2 metabolism]. Arerugi = [Allergy], 1995, Volume: 44, Issue:5 To confirm that the soluble factors produced by peripheral blood mononuclear cells (PBMC) from children with minimal change nephrotic syndrome (MCNS) enhance thromboxane (TX) A2 synthesis, we studied the urinary albumin and TXA2 metabolite excretions of rats intravenously injected with PBMC culture supernatant (PCS). Furthermore, we studied which does mainly effect on urinary albumin excretion, TXA2 metabolism in kidney or in platelet. In this study, the urinary albumin, TXB2, and 11-dehydro-TXB2 excretions of rats injected with PCS from MCNS children were remarkably increased, but this change was not observed in rats injected with PCS from children with MCNS in remission, glomerulonephritis, or healthy controls. The urinary albumin excretion of rats administered with acetylsalitylic acid before injection of PCS from MCNS children did not increase. We concluded that the soluble factors produced by PBMC from MCNS children increase urinary albumin excretion, and that the TXA2 metabolism is closely related to this effect. Topics: Albuminuria; Animals; Aspirin; Blood Platelets; Cells, Cultured; Child; Female; Humans; Kidney Glomerulus; Leukocytes, Mononuclear; Male; Nephrosis, Lipoid; Rats; Rats, Wistar; Thromboxane A2	1995
Preliminary report: renal thromboxane A2 synthesis in children with frequent relapsing nephrotic syndrome. Lancet (London, England), 1990, Sep-01, Volume: 336, Issue:8714 An evaluation was made of the possible relation between renal thromboxane (Tx)A2 synthesis (measured as urinary excretion of TxB2) and the loss of glomerular permeability to proteins, in 5 children with seven episodes of minimal change nephrotic syndrome. Urinary TxB2 excretion was significantly higher in children with minimal change nephrotic syndrome than in 14 healthy controls, and reached its maximum at the time of peak proteinuria. During remission of nephrotic syndrome urinary excretion of TxB2 was still significantly higher than in healthy controls. A significant positive correlation between urinary excretion of TxB2 and proteinuria was observed in 3 patients. The results suggest that renal TxA2 could be regarded as one of the possible mediators of the altered glomerular permeability to proteins in minimal change nephrotic syndrome. Topics: Child; Female; Humans; Kidney; Male; Nephrosis, Lipoid; Proteinuria; Thromboxane A2; Thromboxane B2	1990

Article

Year

[The effect of peripheral blood mononuclear cell products from children with nephrotic syndrome on thromboxane A2 metabolism].

Arerugi = [Allergy], 1995, Volume: 44, Issue:5

To confirm that the soluble factors produced by peripheral blood mononuclear cells (PBMC) from children with minimal change nephrotic syndrome (MCNS) enhance thromboxane (TX) A2 synthesis, we studied the urinary albumin and TXA2 metabolite excretions of rats intravenously injected with PBMC culture supernatant (PCS). Furthermore, we studied which does mainly effect on urinary albumin excretion, TXA2 metabolism in kidney or in platelet. In this study, the urinary albumin, TXB2, and 11-dehydro-TXB2 excretions of rats injected with PCS from MCNS children were remarkably increased, but this change was not observed in rats injected with PCS from children with MCNS in remission, glomerulonephritis, or healthy controls. The urinary albumin excretion of rats administered with acetylsalitylic acid before injection of PCS from MCNS children did not increase. We concluded that the soluble factors produced by PBMC from MCNS children increase urinary albumin excretion, and that the TXA2 metabolism is closely related to this effect.

Topics: Albuminuria; Animals; Aspirin; Blood Platelets; Cells, Cultured; Child; Female; Humans; Kidney Glomerulus; Leukocytes, Mononuclear; Male; Nephrosis, Lipoid; Rats; Rats, Wistar; Thromboxane A2

1995

Preliminary report: renal thromboxane A2 synthesis in children with frequent relapsing nephrotic syndrome.

Lancet (London, England), 1990, Sep-01, Volume: 336, Issue:8714

An evaluation was made of the possible relation between renal thromboxane (Tx)A2 synthesis (measured as urinary excretion of TxB2) and the loss of glomerular permeability to proteins, in 5 children with seven episodes of minimal change nephrotic syndrome. Urinary TxB2 excretion was significantly higher in children with minimal change nephrotic syndrome than in 14 healthy controls, and reached its maximum at the time of peak proteinuria. During remission of nephrotic syndrome urinary excretion of TxB2 was still significantly higher than in healthy controls. A significant positive correlation between urinary excretion of TxB2 and proteinuria was observed in 3 patients. The results suggest that renal TxA2 could be regarded as one of the possible mediators of the altered glomerular permeability to proteins in minimal change nephrotic syndrome.

Topics: Child; Female; Humans; Kidney; Male; Nephrosis, Lipoid; Proteinuria; Thromboxane A2; Thromboxane B2

1990