thromboxane-a2 and Lymphatic-Diseases

Physical interaction of T cells and dendritic cells (DCs) is essential for T cell proliferation and differentiation, but it has been unclear how this interaction is regulated physiologically. Here we show that DCs produce thromboxane A2 (TXA2), whereas naive T cells express the thromboxane receptor (TP). In vitro, a TP agonist enhances random cell movement (chemokinesis) of naive but not memory T cells, impairs DC-T cell adhesion, and inhibits DC-dependent proliferation of T cells. In vivo, immune responses to foreign antigens are enhanced in TP-deficient mice, which also develop marked lymphadenopathy with age. Similar immune responses were seen in wild-type mice treated with a TP antagonist during the sensitization period. Thus, TXA2-TP signaling modulates acquired immunity by negatively regulating DC-T cell interactions.

Topics: Animals; Cell Communication; Cell Movement; Dendritic Cells; Dermatitis, Contact; Female; Hyaluronan Receptors; Immunity; Lymphatic Diseases; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Receptors, Thromboxane; T-Lymphocytes; Thromboxane A2

Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Child, Preschool; Humans; Infant; Lymphatic Diseases; Mucocutaneous Lymph Node Syndrome; Thromboxane A2; Thromboxanes

Topics: 6-Ketoprostaglandin F1 alpha; Animals; Burns; Fistula; Hemodynamics; Lung Diseases; Lymphatic Diseases; Lymphatic System; Prostaglandins; Sheep; Thromboxane A2; Thromboxane B2; Thromboxanes