thromboxane-a2 and Contracture

thromboxane-a2 has been researched along with Contracture* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-a2 and Contracture

Article	Year
Contraction of guinea pig lung parenchyma by pancreatic type phospholipase A2 via its specific binding site. FEBS letters, 1992, Jun-01, Volume: 303, Issue:2-3 Porcine pancreatic group I phospholipase A2 (PLA2-I) induced contraction of guinea pig parenchyma in a concentration-dependent manner. Its EC50 value was similar to the Kd value calculated from the specific binding of 125I-labeled porcine PLA2-I in the membrane fraction of guinea pig lung. Type-specific action of PLA2's and homologous desensitization strongly implicated the involvement of PLA2-I-specific sites in the activation process. Thromboxane A2 was found to be the main product from lung tissue by PLA2-I action and the contractile response by PLA2-I was specifically suppressed by thromboxane A2 receptor antagonists and cyclooxygenase inhibitor, but not by leukotriene receptor antagonist and H1 blocker. These findings indicate that PLA2-I-induced contractile response may depend on the secondarily produced thromboxane A2, thus providing a new aspect of PLA2-I from the pathophysiological standpoint. Topics: Animals; Binding Sites; Contracture; Guinea Pigs; In Vitro Techniques; Lung; Male; Pancreas; Phospholipases A; Phospholipases A2; Thromboxane A2	1992

Article

Year

Contraction of guinea pig lung parenchyma by pancreatic type phospholipase A2 via its specific binding site.

FEBS letters, 1992, Jun-01, Volume: 303, Issue:2-3

Porcine pancreatic group I phospholipase A2 (PLA2-I) induced contraction of guinea pig parenchyma in a concentration-dependent manner. Its EC50 value was similar to the Kd value calculated from the specific binding of 125I-labeled porcine PLA2-I in the membrane fraction of guinea pig lung. Type-specific action of PLA2's and homologous desensitization strongly implicated the involvement of PLA2-I-specific sites in the activation process. Thromboxane A2 was found to be the main product from lung tissue by PLA2-I action and the contractile response by PLA2-I was specifically suppressed by thromboxane A2 receptor antagonists and cyclooxygenase inhibitor, but not by leukotriene receptor antagonist and H1 blocker. These findings indicate that PLA2-I-induced contractile response may depend on the secondarily produced thromboxane A2, thus providing a new aspect of PLA2-I from the pathophysiological standpoint.

Topics: Animals; Binding Sites; Contracture; Guinea Pigs; In Vitro Techniques; Lung; Male; Pancreas; Phospholipases A; Phospholipases A2; Thromboxane A2

1992