thromboxane-a2 and Carcinoma--Lewis-Lung

thromboxane-a2 has been researched along with Carcinoma--Lewis-Lung* in 1 studies

Other Studies

1 other study(ies) available for thromboxane-a2 and Carcinoma--Lewis-Lung

Article	Year
Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice. BMC complementary and alternative medicine, 2009, Jul-01, Volume: 9 Liqi, an herbal preparation used in traditional Chinese medicine, has been used to treat cancer in China for centuries. We investigated the anti-tumor effects of liqi and their mechanisms in mice that had been xenografted with tumors.. Sarcoma 180 tumor, Lewis lung carcinoma, and SGC-7901 cells were implanted in BALB/c mice, C57BL/6 mice, and BALB/c nude mice, respectively. Liqi was administered to subgroups of these mice. The tumor weight and size were measured. Cell cycle analysis and T lymphocyte subsets were determined by flow cytometry. The activity of NK cells and TNF was tested using cytotoxicity assay on YAC-1 cells and L929 cells, respectively, and the activity of IL-2 was tested with an IL-2-dependent CTLL-2 cell proliferation assay. Platelet aggregation was monitored by measuring electric impedance, and the levels of thromboxane A2 (TXA2) and prostacyclin (PGI2) in blood were measured by 125I-TXB2 and 125I-Keto-PGF1alpha radioimmunoassay.. The results showed that liqi inhibited tumor growth in tumor-implanted mice and arrested the cell proliferation in the G0/G1 phase and reduced the portion of cells in S and G2/M phase for SGC-7901 cells. Liqi increased the activity of NK cells and TNF-alpha, stimulated IL-2 production and activity, and regulated T lymphocyte subpopulations. Liqi inhibited the Lewis lung carcinoma metastasis by inhibiting platelet aggregation and normalizing the balance between TXA2 and PGI2.. All these findings demonstrated that liqi has an anti-tumor effect in vivo. The mechanism may be related to immune regulation and anticoagulation effects. Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Epoprostenol; Female; Interleukin-2; Killer Cells, Natural; Lung Neoplasms; Magnoliopsida; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Phytotherapy; Platelet Aggregation; Sarcoma, Experimental; T-Lymphocyte Subsets; Thromboxane A2; Tumor Necrosis Factor-alpha	2009

Article

Year

Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice.

BMC complementary and alternative medicine, 2009, Jul-01, Volume: 9

Liqi, an herbal preparation used in traditional Chinese medicine, has been used to treat cancer in China for centuries. We investigated the anti-tumor effects of liqi and their mechanisms in mice that had been xenografted with tumors.. Sarcoma 180 tumor, Lewis lung carcinoma, and SGC-7901 cells were implanted in BALB/c mice, C57BL/6 mice, and BALB/c nude mice, respectively. Liqi was administered to subgroups of these mice. The tumor weight and size were measured. Cell cycle analysis and T lymphocyte subsets were determined by flow cytometry. The activity of NK cells and TNF was tested using cytotoxicity assay on YAC-1 cells and L929 cells, respectively, and the activity of IL-2 was tested with an IL-2-dependent CTLL-2 cell proliferation assay. Platelet aggregation was monitored by measuring electric impedance, and the levels of thromboxane A2 (TXA2) and prostacyclin (PGI2) in blood were measured by 125I-TXB2 and 125I-Keto-PGF1alpha radioimmunoassay.. The results showed that liqi inhibited tumor growth in tumor-implanted mice and arrested the cell proliferation in the G0/G1 phase and reduced the portion of cells in S and G2/M phase for SGC-7901 cells. Liqi increased the activity of NK cells and TNF-alpha, stimulated IL-2 production and activity, and regulated T lymphocyte subpopulations. Liqi inhibited the Lewis lung carcinoma metastasis by inhibiting platelet aggregation and normalizing the balance between TXA2 and PGI2.. All these findings demonstrated that liqi has an anti-tumor effect in vivo. The mechanism may be related to immune regulation and anticoagulation effects.

Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Epoprostenol; Female; Interleukin-2; Killer Cells, Natural; Lung Neoplasms; Magnoliopsida; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Phytotherapy; Platelet Aggregation; Sarcoma, Experimental; T-Lymphocyte Subsets; Thromboxane A2; Tumor Necrosis Factor-alpha

2009