thromboplastin has been researched along with Vitamin-B-12-Deficiency* in 2 studies
2 other study(ies) available for thromboplastin and Vitamin-B-12-Deficiency
Article | Year |
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Relevance of post-methionine homocysteine and lipoprotein (a) in evaluating the cardiovascular risk in young CAD patients.
Aims of our study were to evaluate the prevalence of high lipoprotein (a) [Lp(a)] and homocysteine levels - both in the fasting state (FHcy) and post-methionine (PMHcy) - in young coronary artery disease (CAD) patients, and to investigate the role of genetic and environmental factors for hyperhomocysteinaemia.. We studied 140 patients with angiographically documented CAD (24 women = 55 years and 116 men = 50 years) and 140 healthy subjects as controls.. Both FHcy [13.2 (5.4-45.8) vs. 9.0 (5.1-24) micromol L(-1)); P < 0.0001] and PMHcy [(39.4 (9.0-66.4) vs. 25.2 (16.4-33.9); P < 0.0001] were significantly higher in patients than in controls. Lp(a) levels were significantly higher in patients than in controls (200 (3-1486) mg L(-1) vs. 97 (10-412) mg L(-1); P < 0.0001). At the multivariate analysis, adjusted for the classical cardiovascular risk factors and creatinine levels, the OR (95% CI) for CAD at young age significantly increased in the fourth quartile of the distribution of FHcy, PMHcy and Lp(a) levels [FHcy: 14.9 (4.1-58), P < 0.0001; PMHcy: 19.2 (4.0-86.3); P < 0.0001; Lp(a): 19.6 (4.7-78.6): < 0.0001]. Vitamin deficiencies were detected in 28/140 (20%) patients. The prevalence of the homozygous C677T (+/+) methylenetetrahydrofolatereductase genotype was higher, but not significantly different, in patients (22.8%) than in controls (18.6%). The allele frequency of the 844ins68 insertion variant in the cystathionine beta-synthase gene was 0.08 in the control group and 0.06 in the patient group.. Results of the present study indicate the usefulness of including fasting and post-methionine Hcy, and Lp(a) determination in the diagnostic panels of young CAD patients, in order to obtain a better assessment of their cardiovascular risk profile. Topics: Adult; Biomarkers; Blood Coagulation; Case-Control Studies; Chelating Agents; Coronary Disease; Fasting; Female; Folic Acid Deficiency; Homocysteine; Humans; Lipoprotein(a); Male; Methionine; Middle Aged; Risk; Statistics, Nonparametric; Thromboplastin; Vitamin B 12 Deficiency | 2005 |
A qualitative platelet defect in severe vitamin B 12 deficiency. Response, hyperresponse, and thrombosis after vitamin B 12 therapy.
Topics: Adenosine Diphosphate; Aged; Biological Assay; Blood Cell Count; Blood Coagulation Factors; Blood Coagulation Tests; Blood Platelet Disorders; Collagen; Colorimetry; Epinephrine; Female; Fibrinogen; Folic Acid; Humans; Lacticaseibacillus casei; Male; Middle Aged; Platelet Adhesiveness; Prothrombin Time; Radioisotope Dilution Technique; Schilling Test; Thromboplastin; Thrombosis; Vitamin B 12; Vitamin B 12 Deficiency | 1973 |