thromboplastin and Purpura--Thrombocytopenic

Plasma tissue factor (TF) antigen can be detected in healthy volunteers and may be significantly increased in patients with disseminated intravascular coagulation (DIC). Plasma TF antigen level in patients with DIC was significantly reduced after therapy. The TF activity of human umbilical vein endothelial cells (HUVEC) cultured with lipopolysaccharide (LPS), cytokines and the medium of cultured mononuclear cells (MNC) was significantly increased. TF expression was induced in HUVEC and MNC by incubation with lipoproteins, suggesting that hyperlipidaemia is a direct risk factor in thrombotic disease. TF activity in HUVEC was significantly increased in the presence of plasma and this activation was higher in patients with thrombotic thrombocytopenic purpura (TTP) and DIC. Enhanced TF production by endothelial cells may be important in the pathogenesis of thrombotic diseases.

Topics: Cells, Cultured; Disseminated Intravascular Coagulation; Endothelium, Vascular; Humans; Lipopolysaccharides; Purpura, Thrombocytopenic; Thromboplastin; Umbilical Veins

Topics: Autoimmune Diseases; Blood Platelets; Child; Child, Preschool; Energy Metabolism; Enzyme Activation; Histocytochemistry; Humans; Hypersensitivity, Delayed; Immunity, Cellular; Infant; Lymphocyte Activation; Lymphocytes; Macrophages; Platelet Count; Purpura, Thrombocytopenic; Thromboplastin

Topics: Adult; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Platelet Disorders; Child; Factor X; Factor XII; Female; Fibrinolysin; Fibrinolysis; Hemostasis; Humans; Lipoproteins; Male; Prothrombin Time; Purpura, Thrombocytopenic; Thrombin; Thromboplastin; Thrombosis; von Willebrand Diseases

Topics: Adolescent; Adult; Blood Coagulation; Blood Coagulation Disorders; Child; Disseminated Intravascular Coagulation; Embolism, Fat; Endotoxins; Fatty Acids; Female; Fibrinolysis; Heart Defects, Congenital; Hemangioma; Hemolysis; Humans; Leukemia; Male; Middle Aged; Mononuclear Phagocyte System; Neoplasms; Pregnancy; Pregnancy Complications; Purpura, Thrombocytopenic; Skin Neoplasms; Thromboplastin

Bernard-Soulier syndrome is a rare constitutional thrombopathy, the main clinical feature is a bleeding tendency which is variable. The long bleeding time, in spite of a normal or little decreased platelet count, has been recently explained: the giant platelets have a defective adhesion to subendothelium. This abnormal adhesion could be related with an abnormal pattern of platelet membrane glycoproteins. Interactions between vessel wall, von Willebrand's factor and platelets are discussed.

Topics: Adenosine Diphosphate; Blood Coagulation Factors; Blood Platelets; Cell Membrane; Cell Survival; Collagen; Factor VIII; Factor XI; Glycoproteins; Humans; Platelet Adhesiveness; Platelet Aggregation; Purpura, Thrombocytopenic; Ristocetin; Serotonin; Sialic Acids; Syndrome; Thromboplastin; von Willebrand Factor

Topics: Adult; Afibrinogenemia; Animals; Blood Cell Count; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Cattle; Citrates; Collagen; Crystallization; Dogs; Edetic Acid; Factor VII Deficiency; Factor X Deficiency; Factor XII; Female; Fibrinogen; Hemophilia A; Hemostasis; Heparin; Humans; Male; Platelet Adhesiveness; Platelet Aggregation; Purpura, Thrombocytopenic; Thrombin; Thromboplastin; von Willebrand Diseases

Topics: Blood Cell Count; Blood Coagulation; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Platelet Disorders; Blood Platelets; Diagnosis, Differential; Disseminated Intravascular Coagulation; Female; Hemoglobinometry; Hemophilia A; Hemophilia B; Hemorrhage; Humans; Male; Prothrombin Time; Purpura; Purpura, Thrombocytopenic; Purpura, Thrombotic Thrombocytopenic; Rheumatic Diseases; Telangiectasia, Hereditary Hemorrhagic; Thromboplastin; von Willebrand Diseases

Topics: Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Fibrin; Fibrinogen; Fibrinolysis; Hematology; Hemophilia A; Hemostasis; History, 15th Century; History, 16th Century; History, 17th Century; History, 18th Century; History, 19th Century; History, 20th Century; History, Ancient; History, Medieval; History, Modern 1601-; Humans; Prothrombin; Prothrombin Time; Purpura, Thrombocytopenic; Thrombin; Thromboplastin

Topics: Absorption; Adenosine; Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Glycolysis; Humans; Indomethacin; Oxidative Phosphorylation; Platelet Adhesiveness; Purpura, Thrombocytopenic; Spectrum Analysis; Thromboplastin; Time Factors

Topics: Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Female; Fibrin; Fibrinogen; Fibrinolysis; Heparin; Humans; Middle Aged; Purpura, Thrombocytopenic; Thrombophlebitis; Thromboplastin

Topics: Animals; Antibodies; Aspirin; Blood Coagulation Tests; Drug Hypersensitivity; Humans; Purpura, Thrombocytopenic; Rabbits; Thromboplastin

Topics: Anticoagulants; Enzyme Inhibitors; Immunoglobulins; Purpura; Purpura, Thrombocytopenic; Thrombocytopenia; Thromboplastin

Topics: Blood Coagulation Tests; Factor X; Fibrinolysis; Humans; Infant; Purpura; Purpura, Thrombocytopenic; Thrombocytopenia; Thromboplastin; Vitamin K 1

Topics: Blood Transfusion; Hemophilia A; Humans; Purpura; Purpura, Thrombocytopenic; Thrombocytopenia; Thromboplastin