thromboplastin and Papilledema

We found distinct alterations of the clotting and fibrinolytic mechanisms in a 27-year-old man who suffered from typical bilateral vasculitis, clinically and fluoroangiographically manifest as obstruction of the central retinal veins. The partial thromboplastin time was slightly increased, a partial clot lysis occurred after one hour, the plasminogen level was markedly low, and alpha2-macroglobulin was decreased, as were factor XII and IgG. Kallikrein was absent. Similar changes, though not so pronounced, were also found in the patient's son and in his brother.

Topics: Adult; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Child, Preschool; Clot Retraction; Edema; Factor XII; Fluorescein Angiography; Humans; Immunoglobulin G; Macroglobulins; Male; Papilledema; Plasminogen; Retinal Diseases; Retinal Hemorrhage; Thromboplastin; Vasculitis