thromboplastin and Meningioma

thromboplastin has been researched along with Meningioma* in 4 studies

Other Studies

4 other study(ies) available for thromboplastin and Meningioma

ArticleYear
Canine intracranial meningiomas: Immunohistochemical evaluation of tissue factor, fibrin/fibrinogen and D-dimers.
    Veterinary journal (London, England : 1997), 2015, Volume: 206, Issue:3

    The haemostatic system influences angiogenesis, cell growth and metastasis in solid tumours. The aim of this study was to investigate tissue factor (TF) expression, fibrin/fibrinogen and D-dimer deposition, as well as the occurrence of intravascular thrombosis (IVT) in canine intracranial meningiomas using immunohistochemistry. All but three (26/29) meningiomas expressed TF. TF immunolabelling was significantly higher in high-grade (grades II and III) than in low-grade (grade I) meningiomas. Fibrin/fibrinogen and D-dimer deposits were detected in all meningiomas and staining scores were statistically different between different meningioma grades. IVT was detected in 19/29 specimens, but no statistical differences were observed between different malignancy grades. In conclusion, the haemostatic system may be involved in meningioma pathobiology and may be a potential therapeutic target for canine meningiomas, as also suggested for human meningiomas.

    Topics: Animals; Dog Diseases; Dogs; Fibrin; Fibrin Fibrinogen Degradation Products; Immunohistochemistry; Meningeal Neoplasms; Meningioma; Thromboplastin

2015
Disseminated intravascular coagulation complicating resection of a malignant meningioma.
    British journal of neurosurgery, 2006, Volume: 20, Issue:4

    A 70-year-old woman developed disseminated intravascular coagulation (DIC) during a craniotomy for a parasagittal anaplastic/malignant meningioma. This was successfully treated with rapid resection of the tumour and haematological replacement, but a poor neurological outcome resulted. The tumour was demonstrated to express tissue factor, an important causative factor in other tumour associated DIC and previously shown to be expressed by malignant meningiomas. A link between the two is suggested.

    Topics: Aged; Brain Neoplasms; Craniotomy; Disseminated Intravascular Coagulation; Female; Humans; Intraoperative Complications; Meningioma; Neoplasm Proteins; Thromboplastin

2006
Clinico-pathological study of meningiomas with haemorrhagic onset.
    Acta neurochirurgica, 2003, Volume: 145, Issue:9

    Haemorrhage from meningiomas is rare and the underlying pathophysiological mechanisms remain to be determined. We sought to identify these mechanisms by studying clinical and histological records of 6 meningioma patients treated at our institution.. We retrospectively studied 6 patients with meningiomas whose acute onset was due to haemorrhage. We evaluated clinical features and imaging studies. The vascularity and proliferative nature of these tumours were examined immunohistochemically and tissue factor (TF) immunoreactivity was assessed. For comparison we evaluated 25 non-haemorrhagic meningiomas.. At onset, the haemorrhages mimicked stroke in all 6 patients. On imaging studies, 3 of the haemorrhages were intra- and extratumoural, the other 3 were extratumoural only. Hyperintensity on T2-weighted MRI was a characteristic of these meningiomas. Histologically, they were of 3 subtypes, meningothelial (n=3), transitional (n=2), and anaplastic (n=1). The MIB-1 labelling index of the 5 WHO Grade I meningiomas was 5.8+/-2.2. The mean number of CD31-positive blood vessels did not differ in haemorrhagic and non-haemorrhagic meningiomas. The TF-positivity rate of haemorrhagic meningiomas was higher than of non-haemorrhagic meningiomas.. The proliferative nature of the meningiomas and TF expression in tumour cells may have contributed to the eventual haemorrhage of the meningiomas in our series.

    Topics: Aged; Aged, 80 and over; Blood Coagulation; Female; Humans; Intracranial Hemorrhages; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neovascularization, Pathologic; Retrospective Studies; Thromboplastin

2003
Local haemostasis in brain tumours.
    Experientia, 1975, Aug-15, Volume: 31, Issue:8

    The thromboplastic activity and the fibrinolytic activity were examined in 7 human meningiomas and 6 gliomas obtained at neurosurgery. Two different haemostatic patterns emerged, meningiomas having lower thromboplastic and higher fibrinolytic activity than that of gliomas. This difference might help to explain the better haemostatic capacity of gliomas during and after operation than that of meningiomas.

    Topics: Adult; Aged; Brain Neoplasms; Female; Fibrinolysis; Glioma; Hemostasis; Humans; Male; Meningioma; Middle Aged; Thromboplastin

1975