thromboplastin and Lymphatic-Diseases

Platelets were studied in a group of 10 patients with typical clinical course, morphological findings, and specific histochemical criteria for leukemic reticuloendotheliosis. In 8 of these, marked qualitative abnormalities were found. These included lack of aggregation following epinephrine stimulation (6 patients), and decreased platelet factor 3 availability following ADP stimulation (4 patients). In addition, platelets in 4 of the 10 patients were studied by electron microscopy. All had granular abnormality, and 1 case showed the presence of rough-surfaced endoplasmic reticulum. The functional and ultrastructural abnormalities of platelets reported here may be responsible for the clinically important bleeding episodes which were not attributable to thrombocytopenia in 2 of our patients. The findings also provide a clue to the basic nature of this histogenetically controversial malignancy.

Topics: Adenosine Diphosphate; Adult; Aged; Blood Platelets; Endoplasmic Reticulum; Epinephrine; Female; Humans; Leukemia; Lymphatic Diseases; Male; Middle Aged; Platelet Aggregation; Thromboplastin

Topics: Acute Disease; Adolescent; Child; Child, Preschool; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphatic Diseases; Thromboplastin

Topics: Blood Coagulation Tests; Genetic Diseases, X-Linked; Hemorrhagic Disorders; Humans; Leukemia; Leukemia, Hairy Cell; Lymphatic Diseases; Metabolism; Severe Combined Immunodeficiency; Thrombocytopenia; Thromboplastin