thromboplastin has been researched along with Fever* in 3 studies
3 other study(ies) available for thromboplastin and Fever
| Article | Year |
|---|---|
Procoagulant tissue factor activity on microparticles is associated with disease severity and bacteremia in febrile urinary tract infections.
Inhibition of tissue factor, the primary initiator of coagulation in sepsis, attenuates morbidity in primates infused with Escherichia coli. In a human endotoxemia model, microparticles expressing procoagulant TF (MP-TF) are released in blood concurrently with markers of inflammation and coagulation. We investigated whether the release of MP-TF into blood is accompanied by procoagulant and inflammatory changes in patients with E. coli urinary tract infection.. In a multicenter cohort study, we determined clinical disease severity using APACHE II scores and measured plasma MP-TF activity, TAT, sE-selectin, sVCAM-1, procalcitonin and monocyte count in blood of 215 patients with community-acquired febrile E. coli urinary tract infections.. Plasma MP-TF activity on admission corresponded with clinical disease severity (APACHE II score; P=0.006) and correlated significantly but weakly with plasma markers of disease severity (sE-selectin, sVCAM-1, procalcitonin). Additionally, median plasma MP-TF activity was higher in patients than in healthy controls (197 vs. 79 fM Xa/min; P<0.0001), and highest in bacteremic patients (325 fM Xa/min). MP-TF activity showed a weak inverse correlation with monocyte count (rs -0.22; P=0.016) and a weak correlation with TAT (rs 0.23, P=0.017). After 3 days of antibiotic treatment, upon resolution of the infection, plasma MP-TF activity and TAT concentrations declined.. Microparticle-associated procoagulant tissue factor activity is related to disease severity and bacteremia in febrile E. coli UTI patients and may contribute to the prothrombotic state in gram-negative sepsis. Topics: Adult; Aged; Aged, 80 and over; Bacteremia; Cell-Derived Microparticles; Cohort Studies; Escherichia coli Infections; Female; Fever; Humans; Male; Middle Aged; Severity of Illness Index; Thromboplastin; Urinary Tract Infections; Young Adult | 2014 |
Hemostatic alterations following severe dysbaric stress.
Topics: Animals; Atmospheric Pressure; Blood Coagulation Disorders; Decompression Sickness; Diving; Environment, Controlled; Fever; Fibrinogen; Hemostasis; Male; Platelet Adhesiveness; Prothrombin Time; Rats; Thrombocytopenia; Thromboplastin; Time Factors | 1974 |
Effects of puff adder venom on the coagulation mechanism. I. In vivo.
Topics: Adult; Animals; Arm; Blood Coagulation; Blood Platelets; Edema; Fever; Humans; Male; Prothrombin Time; Rats; Snakes; Thrombin; Thromboplastin; Venoms | 1973 |