thromboplastin and Edema

Topics: Animals; Bacteremia; Biomarkers; Disseminated Intravascular Coagulation; Dogs; Edema; Escherichia coli Infections; Inflammation; Papio; Protein C; Rats; Shock, Septic; Thromboplastin; Tumor Necrosis Factor-alpha

Carrageenan-induced paw edema has been described as a local and acute inflammatory process. In fact, little is known about the time course and systemic changes following a carrageenan injection. In this study, we examine the systemic changes that follow carrageenan injection in the paw.. Acute inflammation was produced by subplantar injection of carrageenan in a hind paw of Sprague-Dawley rats. Saline was used in control rats. Paw volume was measured with a plethysmometer. The hot plate latency test was used to quantify antinociception. C-reactive protein (CRP) levels were measured with a sandwich enzyme immunoassay. Fibrinogen concentration was measured using the gravimetric method. Lung morphometric analysis was performed using an image processing package. Lungs and paws were also examined for tissue factor (TF) and proinflammatory cytokines expression by immunohistochemistry.. We found diverse systemic changes including increased levels of acute phase proteins, such as CRP and fibrinogen, and a lung inflammatory process characterized by lung edema, fibrin deposition, and leukocyte infiltration. An elevated expression of TF, IL-6, IL-1β, and TNFα, was observed in paw and lung tissue sections by immunohistochemical methods.. This study provides new evidence that a local carrageenan injection induces a systemic response.

Topics: Animals; C-Reactive Protein; Carrageenan; Cytokines; Edema; Fibrinogen; Foot; Inflammation; Lung; Pain Measurement; Rats; Rats, Sprague-Dawley; Thromboplastin

We found distinct alterations of the clotting and fibrinolytic mechanisms in a 27-year-old man who suffered from typical bilateral vasculitis, clinically and fluoroangiographically manifest as obstruction of the central retinal veins. The partial thromboplastin time was slightly increased, a partial clot lysis occurred after one hour, the plasminogen level was markedly low, and alpha2-macroglobulin was decreased, as were factor XII and IgG. Kallikrein was absent. Similar changes, though not so pronounced, were also found in the patient's son and in his brother.

Topics: Adult; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Coagulation Tests; Child, Preschool; Clot Retraction; Edema; Factor XII; Fluorescein Angiography; Humans; Immunoglobulin G; Macroglobulins; Male; Papilledema; Plasminogen; Retinal Diseases; Retinal Hemorrhage; Thromboplastin; Vasculitis

Topics: Adolescent; Adult; Ascites; Bilirubin; Edema; Hepatic Encephalopathy; Hepatitis B Antigens; Humans; Immunologic Techniques; Laparoscopy; Liver Cirrhosis; Liver Function Tests; Neoplasm Proteins; Prognosis; Serum Albumin; Sulfobromophthalein; Thromboplastin; Transaminases; Urobilinogen

Topics: Adult; Animals; Arm; Blood Coagulation; Blood Platelets; Edema; Fever; Humans; Male; Prothrombin Time; Rats; Snakes; Thrombin; Thromboplastin; Venoms

Topics: Animals; Blood Platelets; Edema; Female; Humans; Hypertension, Renal; Immune Sera; Kidney Glomerulus; Kidney Tubules; Microscopy, Electron; Placenta; Pre-Eclampsia; Pregnancy; Proteinuria; Rabbits; Regional Blood Flow; Thromboplastin