thromboplastin and Disease

thromboplastin has been researched along with Disease* in 6 studies

Reviews

2 review(s) available for thromboplastin and Disease

Article	Year
Tissue factor in health and disease. Frontiers in bioscience (Elite edition), 2012, 01-01, Volume: 4, Issue:1 Tissue Factor (TF) is a crucial initiator of the extrinsic coagulation cascade. TF is expressed on cells which are normally sequestered from blood. However, upon injury TF is exposed to the blood resulting in activation of the coagulation cascade. TF dependent generation of coagulation proteases also initiates intracellular signaling through protease activated receptors. Pathologic TF expression is found in patients with a number of different diseases. This review will describe the roles of TF in health and disease as well as discuss approaches to reduce pathologic TF expression. Topics: Disease; Female; Humans; Pregnancy; Thromboplastin	2012
The present status of tissue factor pathway inhibitor. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1992, Volume: 3, Issue:4 Tissue factor pathway inhibitor (TFPI) is the factor Xa-dependent inhibitor of the factor VIIa/tissue factor complex. The plasma concentration of this 276 amino acid, 40 kDa glycoprotein is normally about 100 ng/ml. There are three intravascular pools of TFPI: 50-90% is on the endothelium, 10-50% is in plasma and less than 2.5% is in platelets. The TFPI in plasma is mainly associated with lipoproteins-only about 5% is free TFPI. The lipoprotein-associated TFPI seems to be of less anticoagulant effect than the free TFPI. Both unfractionated heparin, low-molecular-weight heparins and pentosan polysulphate induce release of TFPI after intravenous injection, whereas dermatan sulphate does not. The interactions with TFPI account for a considerable amount of the anticoagulant effect of heparin. Studies have shown increased TFPI levels in plasma from patients with advanced malignancy and in subjects with fatal DIC or septicaemia. The reason for this is unknown. For measuring the anticoagulant activity of TFPI in plasma, end-point or antigen assays may be less useful than the clotting assay with dilute tissue factor. Animal studies indicate that the main physiological role of TFPI is the inhibition of small amounts of tissue factor. TFPI is probably essential for a normal haemostatic balance. Topics: Disease; Heparin; Humans; Lipoproteins; Reference Values; Thromboplastin	1992

Article

Year

Frontiers in bioscience (Elite edition), 2012, 01-01, Volume: 4, Issue:1

Tissue Factor (TF) is a crucial initiator of the extrinsic coagulation cascade. TF is expressed on cells which are normally sequestered from blood. However, upon injury TF is exposed to the blood resulting in activation of the coagulation cascade. TF dependent generation of coagulation proteases also initiates intracellular signaling through protease activated receptors. Pathologic TF expression is found in patients with a number of different diseases. This review will describe the roles of TF in health and disease as well as discuss approaches to reduce pathologic TF expression.

Topics: Disease; Female; Humans; Pregnancy; Thromboplastin

2012

The present status of tissue factor pathway inhibitor.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1992, Volume: 3, Issue:4

Tissue factor pathway inhibitor (TFPI) is the factor Xa-dependent inhibitor of the factor VIIa/tissue factor complex. The plasma concentration of this 276 amino acid, 40 kDa glycoprotein is normally about 100 ng/ml. There are three intravascular pools of TFPI: 50-90% is on the endothelium, 10-50% is in plasma and less than 2.5% is in platelets. The TFPI in plasma is mainly associated with lipoproteins-only about 5% is free TFPI. The lipoprotein-associated TFPI seems to be of less anticoagulant effect than the free TFPI. Both unfractionated heparin, low-molecular-weight heparins and pentosan polysulphate induce release of TFPI after intravenous injection, whereas dermatan sulphate does not. The interactions with TFPI account for a considerable amount of the anticoagulant effect of heparin. Studies have shown increased TFPI levels in plasma from patients with advanced malignancy and in subjects with fatal DIC or septicaemia. The reason for this is unknown. For measuring the anticoagulant activity of TFPI in plasma, end-point or antigen assays may be less useful than the clotting assay with dilute tissue factor. Animal studies indicate that the main physiological role of TFPI is the inhibition of small amounts of tissue factor. TFPI is probably essential for a normal haemostatic balance.

Topics: Disease; Heparin; Humans; Lipoproteins; Reference Values; Thromboplastin

1992

Other Studies

4 other study(ies) available for thromboplastin and Disease

Article	Year
Pulmonary vascular lesions following the repeated intravascular administration of thromboplastin. The American journal of pathology, 1962, Volume: 41 Topics: Arteries; Disease; Humans; Pulmonary Artery; Thromboembolism; Thromboplastin; Vascular Diseases	1962
[Scapulohumeral periarthritis with giant subacromiodeltoid bursitis in an octogenarian: local treatment; relative failure of steroids; success with claudene]. Revue medicale de la Suisse romande, 1958, Volume: 78, Issue:11 Topics: Aged; Bursitis; Disease; Periarthritis; Shoulder; Steroids; Thromboplastin	1958
[Tissue factors in origin of muscular pain]. Rivista critica di clinica medica, 1957, Mar-31, Volume: 56, Issue:5-6 Topics: Disease; Humans; Muscles; Muscular Diseases; Myalgia; Pain; Potassium; Thromboplastin	1957
[Tissue factors in diagnosis of paradontal lesions]. Odontoiatria; revista ibero-americana de medicina de la boca, 1953, Volume: 10, Issue:109 Topics: Disease; Humans; Periodontal Diseases; Periodontium; Thromboplastin	1953