threonine and Parkinson Disease

threonine has been researched along with Parkinson Disease in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (3.77)	18.7374
1990's	1 (1.89)	18.2507
2000's	26 (49.06)	29.6817
2010's	20 (37.74)	24.3611
2020's	4 (7.55)	2.80

Authors

Authors	Studies
Aracil-Bolaños, I; Bejr-Kasem, H; Campolongo, A; Horta-Barba, A; Kulisevsky, J; Marín-Lahoz, J; Martinez-Horta, S; Pagonabarraga, J; Pascual-Sedano, B; Pérez-González, R; Pérez-Pérez, J; Puig-Davi, A; Rivas, E; Ruiz-Barrios, I; Sampedro, F	1
Li, R; Shi, W; Yan, Z; Yao, L	1
Braun, AR; Nathan Kochen, N; Pandey, AK; Sachs, JN; Seaney, D; Vasandani, V; Walters, MA	1
Julku, UH; Kilpeläinen, T; Myöhänen, TT; Svarcbahs, R	1
Galesic, A; Pratt, MR	1
Dai, L; Kuang, S; Li, J; Rao, Z; Tang, X; Yang, L; Zhong, H; Zhong, Z	1
Brotchie, JM; Chiu, WH; Decher, N; Geibl, FF; Henrich, MT; Koprich, JB; Lee, B; Matschke, LA; Oertel, WH; Timmermann, L	1
Beratis, I; Fragkiadaki, S; Kontaxopoulou, D; Koros, C; Marek, K; Papadimitriou, D; Papageorgiou, SG; Papagiannakis, N; Prentakis, A; Seibyl, J; Simitsi, A; Stamelou, M; Stefanis, L; Trapali, XG	1
Smith, PF; Stiles, L; Zheng, Y	1
Baum, L; Chan, AY; Hui, KF; Kuo, SH; Kwan, JY; Lau, CY; Mizuno, Y; Mok, VC; Ng, PW; Tang, NL	1
Ito, G; Iwatsubo, T; Kamikawaji, S; Sano, T	1
Caspell, C; Chen-Plotkin, AS; Chowdhury, S; Coffey, CS; Frasier, M; Irwin, DJ; Jennings, D; Kang, JH; Kieburtz, K; Marek, K; Mollenhauer, B; Pan, S; Shaw, LM; Siderowf, A; Simuni, T; Singleton, A; Tanner, CM; Taylor, P; Toga, AW; Trojanowski, JQ; Waligórska, T	1
Han, H; Liu, C; Liu, Z; Wang, X; Xu, Y; Yang, X; Zhang, J	1
Fujinaga, M; Furutsuka, K; Hashimoto, H; Hatori, A; Kawamura, K; Kumata, K; Nengaki, N; Shimoda, Y; Shiomi, S; Takei, M; Wakizaka, H; Xie, L; Yamasaki, T; Yui, J; Zhang, MR	1
Chen, NH; Gong, XG; Guo, ZY; Hu, JH; Li, P; Ma, L; Sun, HM; Wang, ZZ; Zhang, Y	1
Chen, GS; Chen, ML; Lim, HQ; Lin, CH; Tan, EK; Tan, LC; Wu, RM	1
Greene, LA; Jin, ZH; Malagelada, C	1
Sotiriou, E; Stefanis, L; Vassilatis, DK; Vila, M	1
Auff, E; Balzar, J; Brücke, T; Daniel, G; Edris, S; El Tawil, S; Foki, T; Gasser, T; Haubenberger, D; Katzenschlager, R; Lichtner, P; Pirker, W; Reinthaler, E; Schulte, C; Zimprich, A	1
Bendixen, C; Bertelsen, MF; Hedegaard, C; Larsen, K	1
Baekelandt, V; Beilina, A; Cookson, MR; Deng, J; Greggio, E; Jaffe, H; Merchant, K; Ryder, J; Sun, P; Taymans, JM; Vancraenenbroeck, R; Zhen, EY	1
Farrer, MJ; Keeling, BH; Rajput, A; Ross, OA; Soto-Ortolaza, AI; Uitti, RJ; Vilariño-Güell, C; Wszolek, ZK	1
Ito, G; Iwatsubo, T; Kamikawaji, S	1
Hattori, S; Iida, N; Katayama, Y; Kawakami, F; Maekawa, T; Obata, F; Ohta, E; Tajima, K; Yamamoto, M	1
Hamilton, BA	1
Bax, A; Bodner, CR; Dobson, CM; Maltsev, AS	1
Bateup, HS; Fukui, R; Greengard, P; Hara, M; Hieda, E; Kano, T; Kuroiwa, M; Nishi, A	1
Andersson, M; Blennow, K; Londos, E; Minthon, L; Zetterberg, H	1
Bonifati, V; Cossu, G; Melis, M; Murgia, D; Oostra, BA; Quadri, M; Saddi, V; Simons, EJ; Ticca, A	1
Bwala, G; Hagenah, J; Hung, AY; Klein, C; Krainc, D; Mazzulli, J; Palada, V; Peterlin, B; Terzić, J	1
Eikhof, A; Hempp, C; Mandelkow, EM; Matenia, D; Timm, T	1
Berger, K; Holzmann, C; Krüger, R; Riess, O; Saecker, AM; Schmitt, I; Schöls, L	1
Abou-Sleiman, PM; Ahmadi, KR; Barone, P; Barrone, P; Berciano, J; Bhatia, K; Burk, K; Goldstein, DB; Healy, DG; Kamm, C; Lees, AJ; Moller, JC; Ozawa, T; Quinn, N; Tolosa, E; Wood, NW; Wullner, U	1
Bussell, R; Eliezer, D	1
Auburger, G; Cabin, DE; Gispert-Sanchez, S; Murphy, D; Myers, RR; Nussbaum, RL	1
Kaji, R; Kawakami, H; Kuno, S; Nishimura, M	1
Copeland, NG; Jenkins, NA; Lee, MK; Martin, LJ; Pan, Y; Price, AC; Price, DL; Sterling, W	1
Dzoljić, E; Kostić, V; Krajinović, M; Mirković, D; Nesić, Z; Novaković, I; Prostran, M; Stojanović, R; Todorović, Z	1
Eblan, MJ; Giasson, BI; Goker-Alpan, O; Hurtig, HI; Lee, VM; Nguyen, J; Sidransky, E; Trojanowski, JQ	1
Akbas, N; Bauer, P; Behnke, S; Berg, D; Deplazes, J; Hochstrasser, H; Riess, O; Tomiuk, J; Walter, U	1
Agid, Y; Bonnet, AM; Borg, M; Brice, A; Broussolle, E; Damier, P; Destée, A; Durif, F; Dürr, A; Janin, S; Layet, V; Leclere, L; Lesage, S; Leutenegger, AL; Lohmann, E; Martinez, M; Penet, C; Pollak, P; Rasco, O; Thobois, S; Tison, F; Tranchan, C; Vérin, M; Viallet, F; Vidailhet, M	1
Alessi, DR; Campbell, DG; Deak, M; Gillardon, F; Jaleel, M; Knebel, A; Nichols, RJ	1
Athanassiadou, A; Chung, EJ; Davanos, N; Ki, CS; Kim, JY; Lee, WY; Stavrou, EF	1
Jiang, G; Song, S; Wang, L; Xu, L; Zhu, C	1
Bras, J; Calado, A; Dias, M; Guerreiro, R; Hardy, J; Januario, C; Morgadinho, A; Oliveira, C; Ribeiro, M; Semedo, C; Singleton, A	1
Abboud, H; Clark, RA; Dawson, TM; Habib, SL; Imam, SZ; Ko, HS; Masliah, E; Michel, D; Thomas, B	1
Conway, KA; Harper, JD; Lansbury, PT	2
Alves da Costa, C; Ancolio, K; Checler, F; Uéda, K	1
Conway, KA; Lansbury, PT; Rochet, JC	1
Copeland, NG; Dawson, TM; Jenkins, NA; Lee, MK; Mandir, AS; Price, DL; Qui, D; Stirling, W; Xu, X; Xu, Y	1
Gerstenbrand, F; Gründig, E; Oberhummer, J; Schedl, R; Simanyi, M; Weiss, J	1
Gerstenbrand, F; Gründig, E	1

Trials

1 trial(s) available for threonine and Parkinson Disease

Article	Year
Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy. Journal of the neurological sciences, 2006, Oct-25, Volume: 248, Issue:1-2 Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Cysteine; Female; Homocysteine; Humans; Levodopa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Threonine; Time Factors	2006

Article

Year

Homocysteine serum levels and MTHFR C677T genotype in patients with Parkinson's disease, with and without levodopa therapy.

Journal of the neurological sciences, 2006, Oct-25, Volume: 248, Issue:1-2

Topics: Adult; Aged; Aged, 80 and over; Antiparkinson Agents; Cysteine; Female; Homocysteine; Humans; Levodopa; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Threonine; Time Factors

2006

Other Studies

52 other study(ies) available for threonine and Parkinson Disease

Article	Year
Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease. Parkinsonism & related disorders, 2022, Volume: 105 Topics: Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Humans; Middle Aged; Parkinson Disease; Prospective Studies; tau Proteins; Threonine	2022
Role of the gut-microbiota-metabolite axis in the rotenone model of early-stage Parkinson's Disease. Metabolic brain disease, 2022, Volume: 37, Issue:7 Topics: Alanine; Animals; Asparagine; Gastrointestinal Microbiome; Glutamine; Hydroxyproline; Methionine; Mice; Parkinson Disease; Rotenone; Serine; Threonine	2022
Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth. ACS chemical neuroscience, 2022, 09-07, Volume: 13, Issue:17 Topics: alpha-Synuclein; Humans; Lewy Body Disease; Mutation; Parkinson Disease; Threonine	2022
Behavioural and dopaminergic changes in double mutated human A30PA53T alpha-synuclein transgenic mouse model of Parkinson´s disease. Scientific reports, 2019, 11-22, Volume: 9, Issue:1* Topics: Aging; Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; Humans; Locomotion; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Parkinson Disease; Proline; Threonine	2019
Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein. Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2133 Topics: Acetylglucosamine; alpha-Synuclein; Cysteine; Escherichia coli; Esters; Gene Expression; Glycosylation; Humans; Parkinson Disease; Peptide Biosynthesis; Peptides; Plasmids; Protein Engineering; Recombinant Proteins; Solid-Phase Synthesis Techniques; Sulfhydryl Compounds; Threonine	2020
Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson's Disease. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2018, Volume: 45, Issue:2 Topics: Alanine; alpha-Synuclein; Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Ginkgo biloba; Glutathione; Glutathione Peroxidase; Locomotion; Malondialdehyde; Mice; Mice, Transgenic; Muscle Strength; Mutation; Parkinson Disease; Plant Extracts; Superoxide Dismutase; Swimming; Threonine	2018
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta neuropathologica communications, 2018, 05-10, Volume: 6, Issue:1 Topics: Alanine; alpha-Synuclein; Animals; Calcium-Binding Proteins; Disease Models, Animal; Endopeptidase K; Humans; Locus Coeruleus; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Mutation; Nerve Tissue Proteins; Neuroglia; Neurons; Parkinson Disease; Protein Aggregates; Protein Transport; Threonine; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase	2018
123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society, 2018, Volume: 33, Issue:11 Topics: Adult; Alanine; alpha-Synuclein; Cognition Disorders; Cohort Studies; Corpus Striatum; Dopamine; Female; Functional Laterality; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Threonine; Tomography, Emission-Computed, Single-Photon; Tropanes	2018
The effects of electrical stimulation of the peripheral vestibular system on neurochemical release in the rat striatum. PloS one, 2018, Volume: 13, Issue:10 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Dopamine; Electric Stimulation; Electric Stimulation Therapy; Electrodes; Male; Neostriatum; Parkinson Disease; Peripheral Nervous System; Rats; Rats, Wistar; Serine; Taurine; Threonine; Vestibular Nerve	2018
The role of the Ala746Thr variant in the ATP13A2 gene among Chinese patients with Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:5 Topics: Age of Onset; Alanine; Asian People; Genetic Predisposition to Disease; Hong Kong; Humans; Middle Aged; Parkinson Disease; Proton-Translocating ATPases; Risk Factors; Threonine	2013
Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation. Biochemistry, 2013, Sep-03, Volume: 52, Issue:35 Topics: Chromatography, Thin Layer; HEK293 Cells; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mutation; Parkinson Disease; Peptide Mapping; Phosphopeptides; Phosphorylation; Protein Serine-Threonine Kinases; Threonine	2013
Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. JAMA neurology, 2013, Volume: 70, Issue:10 Topics: alpha-Synuclein; Amyloid beta-Peptides; Case-Control Studies; Cohort Studies; Female; Humans; Male; Memory; Middle Aged; Movement; Neuropsychological Tests; Parkinson Disease; Peptide Fragments; Phosphorylation; Regression Analysis; Severity of Illness Index; Statistics as Topic; tau Proteins; Threonine; Verbal Learning	2013
Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study. PloS one, 2015, Volume: 10, Issue:3 Topics: Adult; Alleles; Asian People; Case-Control Studies; China; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histamine; Histamine N-Methyltransferase; Humans; Isoleucine; Male; Parkinson Disease; Polymorphism, Genetic; Schizophrenia; Threonine	2015
Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Jan-13, Volume: 36, Issue:2 Topics: Alanine; alpha-Synuclein; Animals; Corpus Striatum; Disease Models, Animal; Disease Progression; Excitatory Amino Acid Agents; Exploratory Behavior; Female; Humans; Motor Activity; Oximes; Parkinson Disease; Protein Binding; Pyridines; Radioisotopes; Radionuclide Imaging; Rats; Rats, Transgenic; Receptors, Metabotropic Glutamate; Threonine; Time Factors	2016
Overexpression of DJ-1/PARK7, the Parkinson's disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells. The European journal of neuroscience, 2016, Volume: 43, Issue:10 Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Dopaminergic Neurons; Electron Transport Complex I; Glycogen Synthase Kinase 3 beta; Humans; Mitochondria; Parkinson Disease; Phosphorylation; Protein Deglycase DJ-1; Proto-Oncogene Proteins c-akt; Rats; Threonine	2016
Novel ATP13A2 variant associated with Parkinson disease in Taiwan and Singapore. Neurology, 2008, Nov-18, Volume: 71, Issue:21 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Asian People; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Models, Molecular; Mutation; Parkinson Disease; Positron-Emission Tomography; Proton-Translocating ATPases; Singapore; Taiwan; Threonine; Young Adult	2008
RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Dec-31, Volume: 28, Issue:53 Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Death; Cells, Cultured; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Melanins; Neurons; Oncogene Protein v-akt; Oxidopamine; Parkinson Disease; Phosphorylation; Rats; Serine; Substantia Nigra; Superior Cervical Ganglion; Sympatholytics; Threonine; Time Factors; Transcription Factors; Transfection	2008
Selective noradrenergic vulnerability in α-synuclein transgenic mice. Neurobiology of aging, 2010, Volume: 31, Issue:12 Topics: Alanine; alpha-Synuclein; Animals; Disease Models, Animal; Humans; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Norepinephrine; Parkinson Disease; Threonine	2010
PARK11 gene (GIGYF2) variants Asn56Ser and Asn457Thr are not pathogenic for Parkinson's disease. Parkinsonism & related disorders, 2009, Volume: 15, Issue:7 Topics: Aged; Asparagine; Austria; Carrier Proteins; DNA Mutational Analysis; Egypt; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Germany; Humans; Male; Middle Aged; Parkinson Disease; Polymorphism, Single Nucleotide; Serine; Threonine; White People	2009
Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals. Biochemical and biophysical research communications, 2009, Sep-25, Volume: 387, Issue:3 Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Conserved Sequence; Evolution, Molecular; Humans; Longevity; Molecular Sequence Data; Parkinson Disease; Sequence Alignment; Threonine	2009
The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites. Biochemical and biophysical research communications, 2009, Nov-20, Volume: 389, Issue:3 Topics: Amino Acid Sequence; Cell Line; GTP Phosphohydrolases; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Molecular Sequence Data; Mutation; Parkinson Disease; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Threonine	2009
Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor. Parkinsonism & related disorders, 2010, Volume: 16, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Essential Tremor; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Histamine N-Methyltransferase; Humans; Isoleucine; Male; Middle Aged; Parkinson Disease; Polymorphism, Genetic; Psychiatric Status Rating Scales; Threonine	2010
Identification of the autophosphorylation sites of LRRK2. Biochemistry, 2009, Nov-24, Volume: 48, Issue:46 Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Antibodies; Biocatalysis; Cell Line; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Holoenzymes; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Microfilament Proteins; Parkinson Disease; Peptide Fragments; Phosphorylation; Phosphothreonine; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Recombinant Proteins; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spodoptera; Threonine; Transfection	2009
I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule. Biochemical and biophysical research communications, 2009, Dec-18, Volume: 390, Issue:3 Topics: Amino Acid Substitution; Cell Line; Humans; Isoleucine; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Parkinson Disease; Protein Serine-Threonine Kinases; Protein Stability; Threonine; Transfection	2009
Letter to the editor on "Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals". Biochemical and biophysical research communications, 2010, Jan-01, Volume: 391, Issue:1 Topics: alpha-Synuclein; Amino Acid Sequence; Animals; Cercopithecidae; Conserved Sequence; Humans; Mutation; Parkinson Disease; Platyrrhini; Threonine	2010
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy. Biochemistry, 2010, Feb-09, Volume: 49, Issue:5 Topics: Alanine; alpha-Synuclein; Genetic Variation; Glutamic Acid; Humans; Lysine; Magnetic Resonance Spectroscopy; Mutagenesis, Site-Directed; Parkinson Disease; Peptide Fragments; Phospholipids; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Solutions; Threonine	2010
Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons. Journal of neurochemistry, 2010, Volume: 113, Issue:4 Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Catalytic Domain; Cyclic AMP Response Element-Binding Protein; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neurons; Organ Culture Techniques; Parkinson Disease; Phosphorylation; Receptor, Adenosine A2A; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-1; Receptors, Dopamine D2; Signal Transduction; Threonine	2010
The cognitive profile and CSF biomarkers in dementia with Lewy bodies and Parkinson's disease dementia. International journal of geriatric psychiatry, 2011, Volume: 26, Issue:1 Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Biomarkers; Brief Psychiatric Rating Scale; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lewy Body Disease; Male; Parkinson Disease; Peptide Fragments; Threonine	2011
Broadening the phenotype of TARDBP mutations: the TARDBP Ala382Thr mutation and Parkinson's disease in Sardinia. Neurogenetics, 2011, Volume: 12, Issue:3 Topics: Aged; Alanine; Amino Acid Substitution; Case-Control Studies; Cohort Studies; DNA Mutational Analysis; DNA-Binding Proteins; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Italy; Male; Middle Aged; Mutation, Missense; Nerve Degeneration; Parkinson Disease; Threonine	2011
Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease. Neurobiology of aging, 2012, Volume: 33, Issue:4 Topics: Asian People; Case-Control Studies; Chi-Square Distribution; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Histamine N-Methyltransferase; Humans; Isoleucine; Male; Meta-Analysis as Topic; Parkinson Disease; Polymorphism, Single Nucleotide; Threonine; White People	2012
Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. The Journal of biological chemistry, 2012, Mar-09, Volume: 287, Issue:11 Topics: Amino Acid Substitution; Animals; Biological Transport, Active; Cell Survival; CHO Cells; Cricetinae; Cricetulus; HEK293 Cells; Humans; Mitochondria; Mutation, Missense; Neurons; Parkinson Disease; PC12 Cells; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Spodoptera; Threonine	2012
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996), 2003, Volume: 110, Issue:1 Topics: Aged; alpha-Synuclein; Cell Culture Techniques; Cysteine; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Genes, Reporter; Glycine; Haplotypes; Humans; Male; Middle Aged; Nerve Tissue Proteins; Neuroblastoma; Parkinson Disease; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Synucleins; Threonine; Transfection	2003
A functional polymorphism regulating dopamine beta-hydroxylase influences against Parkinson's disease. Annals of neurology, 2004, Volume: 55, Issue:3 Topics: Animals; Case-Control Studies; Chi-Square Distribution; Cohort Studies; Dopamine beta-Hydroxylase; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Male; Middle Aged; Multiple System Atrophy; Odds Ratio; Pan troglodytes; Parkinson Disease; Polymorphism, Genetic; Threonine	2004
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein. Biochemistry, 2004, Apr-27, Volume: 43, Issue:16 Topics: Alanine; alpha-Synuclein; Humans; Lipid Metabolism; Liposomes; Micelles; Mutation, Missense; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Parkinson Disease; Phosphatidic Acids; Phosphatidylcholines; Proline; Protein Binding; Protein Structure, Secondary; Recombinant Proteins; Synucleins; Threonine	2004
Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background. Neurobiology of aging, 2005, Volume: 26, Issue:1 Topics: Age Factors; Alanine; alpha-Synuclein; Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Motor Activity; Mutation; Nerve Tissue Proteins; Parkinson Disease; Phenylenediamines; RNA; Sciatic Nerve; Spinal Cord; Synucleins; Threonine; Wallerian Degeneration	2005
Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society, 2005, Volume: 20, Issue:8 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cysteine; Female; Genetic Predisposition to Disease; Humans; Japan; Male; Methionine; Middle Aged; Multiple System Atrophy; Parkinson Disease; Polymorphism, Genetic; Threonine; Valine	2005
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-04, Volume: 26, Issue:1 Topics: Alanine; alpha-Synuclein; Animals; Brain Stem; Cell Death; DNA Damage; Humans; Mice; Mice, Transgenic; Mitochondria; Mutation; Neocortex; Nerve Degeneration; Parkinson Disease; Threonine	2006
Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurology, 2006, Sep-12, Volume: 67, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Asparagine; Autopsy; Brain; DNA Mutational Analysis; Female; Glucosylceramidase; Humans; Isoleucine; Lewy Body Disease; Male; Middle Aged; Mutation; Parkinson Disease; Risk Factors; Synucleins; Threonine	2006
Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Neuroscience letters, 2006, Oct-16, Volume: 407, Issue:1 Topics: Aged; Aspartic Acid; Chromatography, High Pressure Liquid; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Testing; Hemochromatosis Protein; Histocompatibility Antigens Class I; Humans; Isoleucine; Male; Membrane Proteins; Middle Aged; Mucoproteins; Mutation; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Threonine	2006
LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans. Archives of neurology, 2007, Volume: 64, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; DNA Mutational Analysis; Europe; Exons; Female; Histidine; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Parkinson Disease; Protein Serine-Threonine Kinases; Serine; Threonine; Tyrosine	2007
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. The Biochemical journal, 2007, Jul-15, Volume: 405, Issue:2 Topics: Amino Acid Sequence; Animals; Cytoskeletal Proteins; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Membrane Proteins; Microfilament Proteins; Parkinson Disease; Protein Serine-Threonine Kinases; Rats; Threonine	2007
The Ala53Thr mutation in the alpha-synuclein gene in a Korean family with Parkinson disease. Clinical genetics, 2007, Volume: 71, Issue:5 Topics: Adult; Age of Onset; Alanine; alpha-Synuclein; Amino Acid Substitution; Family; Haplotypes; Humans; Korea; Male; Mutation; Parkinson Disease; Pedigree; Threonine	2007
Association study of human MTH1 Ile45Thr polymorphism with sporadic Parkinson's disease. European neurology, 2008, Volume: 59, Issue:1-2 Topics: Aged; Aged, 80 and over; Chi-Square Distribution; China; DNA Repair Enzymes; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Isoleucine; Male; Middle Aged; Parkinson Disease; Phosphoric Monoester Hydrolases; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sex Factors; Threonine	2008
Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2. BMC neurology, 2008, Jan-22, Volume: 8 Topics: Aged; alpha-Synuclein; DNA Mutational Analysis; Exons; Family Health; Female; Genetic Predisposition to Disease; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Methionine; Middle Aged; Mutation; Parkinson Disease; Portugal; Protein Kinases; Protein Serine-Threonine Kinases; Threonine; Ubiquitin-Protein Ligases	2008
Role of tuberin in neuronal degeneration. Neurochemical research, 2008, Volume: 33, Issue:6 Topics: Animals; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Parkinson Disease; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Threonine; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins	2008
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nature medicine, 1998, Volume: 4, Issue:11 Topics: Age of Onset; Alanine; alpha-Synuclein; Amino Acid Substitution; Circular Dichroism; Humans; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Electron; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Neurons; Parkinson Disease; Phosphoproteins; Point Mutation; Recombinant Proteins; Substantia Nigra; Synucleins; Threonine	1998
Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid. Biochemistry, 2000, Mar-14, Volume: 39, Issue:10 Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Benzothiazoles; Binding Sites; Brain; Circular Dichroism; Congo Red; Endopeptidases; Humans; Hydrolysis; Immunohistochemistry; Lewy Bodies; Microscopy, Atomic Force; Microscopy, Polarization; Molecular Sequence Data; Mutation, Missense; Nerve Tissue Proteins; Parkinson Disease; Postmortem Changes; Proline; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Thiazoles; Threonine	2000
Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells. Neuroscience letters, 2000, May-12, Volume: 285, Issue:2 Topics: Alanine; alpha-Synuclein; Amino Acid Substitution; Animals; Cell Line; Cysteine Endopeptidases; Humans; Mice; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Synucleins; Threonine; Transfection	2000
Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry, 2000, Sep-05, Volume: 39, Issue:35 Topics: Alanine; alpha-Synuclein; Amyloid; Animals; Chromatography, Gel; Humans; Mice; Microscopy, Atomic Force; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Parkinson Disease; Protein Conformation; Protein Folding; Protein Precursors; Spectroscopy, Fourier Transform Infrared; Synucleins; Threonine	2000
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, 2002, Jun-25, Volume: 99, Issue:13 Topics: Alanine; alpha-Synuclein; Animals; Humans; Mice; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Parkinson Disease; Reverse Transcriptase Polymerase Chain Reaction; Synucleins; Threonine	2002
[Biochemical aspects of the effect of L-dopa in patients with Parkinson's disease]. Zeitschrift fur Neurologie, 1972, Volume: 203, Issue:1 Topics: Cysteine; Cystine; Dihydroxyphenylalanine; Female; Glycine; Humans; Male; Methionine; Parkinson Disease; Serine; Threonine; Time Factors	1972
[Correlation between Parkinsonism symptoms and a disorder in the amino acid metabolism in CNS]. Wiener klinische Wochenschrift, 1970, Nov-06, Volume: 82, Issue:45 Topics: Amino Acids; Animals; Brain Injuries; Central Nervous System Diseases; Cerebrospinal Fluid; Cysteine; Cystine; Diagnosis, Differential; Glycine; Humans; Parkinson Disease; Parkinson Disease, Postencephalitic; Phenothiazines; Rats; Serine; Threonine; Tremor	1970