threonine has been researched along with Acute Confusional Senile Dementia in 100 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (10.00) | 18.2507 |
| 2000's | 53 (53.00) | 29.6817 |
| 2010's | 23 (23.00) | 24.3611 |
| 2020's | 14 (14.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bjerke, M; Bridel, C; De Deyn, PP; Engelborghs, S; Nagels, G; Niemantsverdriet, E; Rozemuller, A; Sieben, A; Somers, C; Struyfs, H; Teunissen, CE; Van Broeckhoven, C; Vermeiren, Y | 1 |
| Barthélemy, NR; Bateman, RJ; Benzinger, TLS; Cruchaga, C; Fagan, AM; Farlow, MR; Goate, A; Graff-Radford, NR; Hassenstab, J; Laske, C; Levin, J; Lim, YY; Maruff, P; Masters, CL; McDade, E; Morris, JC; Salloway, S; Sato, C; Schofield, PR; Xiong, C | 1 |
| Huang, YY; Shen, XN; Tan, L; Wang, HF; Yang, YX; Yu, JT | 1 |
| Alosco, ML; Aparicio, HJ; Ashton, NJ; Au, R; Blennow, K; Budson, AE; Frank, B; Goldstein, LE; Jun, GR; Karikari, TK; Killiany, R; Kowall, NW; Martin, B; McKee, AC; Mez, J; Morrison, MS; Palmisano, JN; Qiu, WQ; Stein, TD; Steinberg, EG; Stern, RA; Sugarman, MA; Tripodis, Y; Turk, KW; Zetterberg, H | 1 |
| Aracil-Bolaños, I; Bejr-Kasem, H; Campolongo, A; Horta-Barba, A; Kulisevsky, J; Marín-Lahoz, J; Martinez-Horta, S; Pagonabarraga, J; Pascual-Sedano, B; Pérez-González, R; Pérez-Pérez, J; Puig-Davi, A; Rivas, E; Ruiz-Barrios, I; Sampedro, F | 1 |
| Banks, SJ; Brewer, JB; Edland, SD; Galasko, D; Reas, ET; Sundermann, EE; Tsiknia, AA | 1 |
| Ahel, HI; Asih, PR; Gajwani, M; Ittner, A; Poljak, A; Stefanoska, K; Tan, ARP; Volkerling, A | 1 |
| Chatzipanagiotou, S; Constantinides, VC; Daskalaki, A; Gargalionis, AN; Kalligerou, F; Mamalaki, E; Ntanasi, E; Patas, K; Scarmeas, N; Yannakoulia, M | 1 |
| Maitra, S; Vincent, B | 1 |
| Frade, JM; Llabrés-Mas, AM; López-Sánchez, N; Lozano-Ureña, A; Ramón-Landreau, M; Sánchez-Puelles, C | 1 |
| Bloom, GS; Guruacharya, A; Mandell, JW; Rajbanshi, B | 1 |
| Grossmann, K; Risch, L; Saely, CH; Telser, J; Werner, P; Wohlwend, N | 1 |
| Cullen, N; Dage, JL; Hansson, O; Janelidze, S; Mattsson-Carlgren, N; Mengel, D; Palmqvist, S; Stomrud, E; Strandberg, O; Svenningsson, AL; Walsh, DM | 1 |
| Ashton, NJ; Blennow, K; Grothe, MJ; Karikari, TK; Moscoso, A; Rodriguez, JL; Schöll, M; Snellman, A; Suárez-Calvet, M; Zetterberg, H | 1 |
| Chun, YS; Chung, S; Kwon, OH | 1 |
| Bennett, DA; Bianco, AC; Chaker, L; Evans, DA; Jo, S; Mash, DC; McAninch, EA; Peeters, RP; Rajan, KB | 1 |
| Chen, SG; Gao, J; Huntley, ML; Perry, G; Siedlak, SL; Termsarasab, P; Wang, L; Wang, X; Yan, T | 1 |
| Attems, J; Daum, G; Flunkert, S; Hoeller, C; Hutter-Paier, B; Kerschbaumer, B; Loeffler, T; Neddens, J; Niederkofler, V; Temmel, M | 1 |
| An, SSA; Bagyinszky, E; Jeong, JH; Kim, S; Koh, SB; Lee, HM; Van Giau, V | 1 |
| An, Y; Chan, HE; Chan, WW; Chau, DD; Hao, Y; Lau, KF; Ngo, JC; Yung, KW | 1 |
| Andreasen, N; Li, TQ; Li, X; Wahlund, LO; Westman, E; Wiberg, MK | 1 |
| Conicella, AE; Fawzi, NL | 1 |
| Achouri-Rassas, A; Anane, N; Belal, S; Ben Ali, N; Chabbi, S; Cherif, A; Fray, S; Gouider, R; Hadj Fredj, S; Kechaou, M; Messaoud, T; Zakraoui, NO | 1 |
| Bowers, MT; Liu, D; Roychaudhuri, R; Teplow, DB; Zheng, X | 1 |
| Cadinu, D; Dennissen, FJ; Hochgräfe, K; Joseph, M; Könen, S; Mandelkow, EM; Matenia, D; Petrova, O; Sydow, A | 1 |
| Belfort, G; Chacko, AR; Das, P | 1 |
| Bagnoli, S; Berti, V; Ferrari, C; Ginestroni, A; Lombardi, G; Lucidi, G; Moretti, M; Nacmias, B; Piaceri, I; Polito, C; Pupi, A; Sorbi, S; Tedde, A | 1 |
| Han, W; Wu, YD; Xiong, H | 1 |
| Green, KN; LaFerla, FM; Martinez-Coria, H; Schreiber, SS; Steffan, JS; Sun, X; Thompson, LM | 1 |
| Bini, P; Costa, A; Franciotta, D; Moglia, A; Ravaglia, S; Sinforiani, E; Tosca, P; Zardini, E | 1 |
| Aisen, PS; Blennow, K; Clark, CM; Dean, R; Knapik-Czajka, M; Lee, VM; Lewczuk, P; Petersen, RC; Potter, W; Shaw, LM; Siemers, E; Simon, A; Soares, H; Trojanowski, JQ; Vanderstichele, H | 1 |
| Blankenstein, MA; Bouwman, FH; Klein, M; Scheltens, P; van der Flier, WM; van der Vlies, AE; Verwey, NA | 1 |
| Bowser, R; Caltagarone, J; Jing, Z | 1 |
| De Deyn, PP; Engelborghs, S; Koopman, K; Le Bastard, N; Martin, JJ; Nagels, G | 1 |
| Albertini, V; Benussi, L; Bernardini, S; Binetti, G; Bruno, A; Cassetta, E; Ghidoni, R; Paterlini, A; Rossini, PM; Squitieri, F; Squitti, R | 1 |
| Barkhof, F; Barnes, J; Blankenstein, MA; Fox, NC; Henneman, WJ; Klein, M; Scheltens, P; Sluimer, IC; van der Flier, WM; Verwey, NA; Vrenken, H | 1 |
| Chung, SH; Son, MY | 1 |
| Barrett, L; Callahan, LM; Eberwine, J; Federoff, H; Kim, M; Kim, TK; Powers, JM; Sharma, A; Sul, JY | 1 |
| Alosco, ML; Griffith, HR; Mielke, MM; Okonkwo, OC; Shaw, LM; Tremont, G; Trojanowski, JQ | 1 |
| Frommann, I; Jessen, F; Kölsch, H; Kornhuber, J; Lewczuk, P; Maier, W; Popp, J | 1 |
| Aisen, PS; Craig, DW; DeChairo, BM; Foroud, T; Huentelman, MJ; Kim, S; Nho, K; Petersen, RC; Potkin, SG; Risacher, SL; Saykin, AJ; Shaw, LM; Shen, L; Swaminathan, S; Trojanowski, JQ; Weiner, MW | 1 |
| Bertelsen, S; Chiang, HH; Cruchaga, C; Goate, A; Graff, C; Hinrichs, AL; Mayo, K; Morris, JC; Norton, JB; Spiegel, N; Wang, J | 1 |
| Hsieh, SH; Sankaranarayanan, S; Savage, MJ; Simon, AJ; Wu, G | 1 |
| Blennow, K; Brinkmalm, G; Halim, A; Larson, G; Nilsson, J; Portelius, E; Rüetschi, U; Westman-Brinkmalm, A; Zetterberg, H | 1 |
| Laezza, F; Reese, LC; Taglialatela, G; Woltjer, R | 1 |
| Hornbeck, L; Judge, M; Padmanabhan, J; Potter, H | 1 |
| Andreasen, N; Arai, H; Blennow, K; Buerger, K; Davies, P; DeBernardis, J; Hampel, H; Hofmann-Kiefer, K; Kerkman, D; Kohnken, R; McCulloch, C; Möller, HJ; Padberg, F; Pirttilä, T; Rapoport, SI; Schapiro, MB; Tapiola, T; Teipel, SJ; Zinkowski, R | 1 |
| Andreasen, N; Arai, H; Blennow, K; Buerger, K; Davies, P; DeBernardis, J; Engel, R; Hampel, H; Heun, R; Hofmann-Kiefer, K; Kerkman, D; McCulloch, C; Moeller, H; Ptok, U; Teipel, SJ; Zinkowski, R | 1 |
| Arai, H; Buerger, K; DeBernardis, J; Faltraco, F; Goernitz, A; Hampel, H; Kerkman, D; McCulloch, C; Möller, HJ; Padberg, F; Pirttilä, T; Rapoport, SI; Tapiola, T; Teipel, SJ; Zinkowski, R | 1 |
| Buerger, K; Hampel, H; Hunt, A; Pantel, J; Schönknecht, P; Schröder, J; Volkmann, M | 1 |
| Hong, CJ; Liu, HC; Liu, TY; Tsai, SJ; Wang, KY | 1 |
| Cheung, J; Feng, GY; He, L; Ichimura, K; St Clair, D; Yang, JD; Zhang, J | 1 |
| Buxbaum, JD; Causevic, M; Davis, KL; Haroutunian, V; Ramoz, N | 1 |
| Ichinose, T; Yamauchi, T; Yoshimura, Y | 1 |
| Chang, NS; Heath, J; Hsu, LJ; Jambal, P; Pugazhenthi, S; Schultz, L; Su, M; Sze, CI | 1 |
| Beck, G; Bibl, M; Esselmann, H; Kornhuber, J; Lewczuk, P; Maler, JM; Otto, M; Wiltfang, J | 1 |
| Bernardi, G; Kawarai, T; Orlacchio, A; Paterson, AD; Polidoro, M; Rogaeva, E; St George-Hyslop, PH | 1 |
| Cittadella, R; La Bella, V; Liguori, M; Manna, I; Piccoli, F; Piccoli, T; Quattrone, A; Settipani, N | 1 |
| Bonvicini, C; Cavazzin, C; Gennarelli, M; Govoni, S; Kasahara, J; Nocera, A; Popoli, M; Racagni, G; Racchi, M; Tardito, D | 1 |
| Corder, EH; Helisalmi, S; Hiltunen, M; Iivonen, S; Koivisto, AM; Lehtovirta, M; Mannermaa, A; Soininen, H; Vepsäläinen, S | 1 |
| Armstrong, J; Boada, M; Ferrer, I; Rey, MJ; Vidal, N | 1 |
| Harris, PL; Lee, HG; Moreira, P; Perry, G; Smith, MA; Webber, KM; Zhu, X | 1 |
| Kaji, R; Kawakami, H; Kuno, S; Nishimura, M | 1 |
| Bürger, K; Davies, P; DeBernardis, J; Evans, AC; Hampel, H; Kerkman, D; Leinsinger, G; Möller, HJ; Pruessner, JC; Teipel, SJ; Zinkowski, R | 1 |
| Bégard, S; Buée, L; Delacourte, A; Drobecq, H; Ghestem, A; Gompel, M; Grognet, P; Grosjean, ME; Hamdane, M; Kostanjevecki, V; Sergeant, N; Vanmechelen, E; Vingtdeux, V | 1 |
| Arena, S; D'Adamio, L; D'Ambrosio, C; Fulcoli, G; Scaloni, A; Scheinfeld, MH; Zhou, D | 1 |
| Imoto, M; Kajioka, T; Kosuga, S; Shimizu, Y; Tashiro, E; Ueki, M | 1 |
| Gong, CX; Grundke-Iqbal, I; Iqbal, K; Liu, F | 1 |
| Blennow, K; Buerger, K; Cepek, L; DeBernardis, J; Hampel, H; Kerkman, D; Kretzschmar, H; McCulloch, C; Möller, HJ; Otto, M; Schönknecht, P; Schröder, J; Teipel, SJ; Wiltfang, J; Zinkowski, R | 1 |
| An, WL; Benedikz, E; Götz, J; Nishimura, T; Norberg, J; Pei, JJ; Winblad, B; Zhou, XW | 1 |
| Bosch, R; Farías, G; Fuentes, P; Guillón, M; Lavados, M; Maccioni, RB; Mujica, C | 1 |
| Cripps, D; Davies, P; Jeng, Y; Thomas, SN; Yang, AJ; Yang, F | 1 |
| Balastik, M; Finn, G; Li, SH; Li, X; Lim, J; Lu, KP; Lu, PJ; Nicholson, LK; Pastorino, L; Sun, A; Wulf, G; Xia, W; Zhou, XZ | 1 |
| Baik, TK; Chang, KA; Ha, JW; Ha, TY; Jeong, YH; Kim, HS; Kim, S; Lee, JP; Park, CH; Shin, KY; Suh, YH | 1 |
| Arendt, T; Grosche, J; Härtig, W; Hoffmann, R; Lehmann, J; Singer, D; Stieler, J | 1 |
| Lee, P; Medina, L; Ringman, JM | 1 |
| Gandy, S; Iijima, K; Iijima-Ando, K; Itohara, S; Mathews, PM; Nakaya, T; Pedrini, S; Sano, Y; Suzuki, T; Takeda, S | 1 |
| Kapaki, EN; Kararizou, E; Paraskevas, GP; Seretis, A; Sfagos, C; Tzerakis, NG; Vassilopoulos, D | 1 |
| Ishihara, T; Kitamoto, T; Nakashima, H; Ogino, K; Shimabuku, A; Shin, RW; Taki, T | 1 |
| Bartolomé, F; Bermejo, F; Martín-Requero, A; Muñoz, U | 1 |
| Ahn, YS; Cheon, YH; Cho, HJ; Chung, SH; Jeong, HK; Kim, IS; Lee, HW; Radnaabazar, C; Ryoo, SR; Song, WJ; Yoo, JJ | 1 |
| Cho, HJ; Chung, SH; Jeong, HK; Kim, MJ; Kim, YS; Lee, HW; Radnaabazar, C; Ryoo, SR; Seo, H; Son, MY; Song, WJ | 1 |
| Ikeuchi, T; Ishikawa, A; Ito, G; Iwatsubo, T; Kakita, A; Kaneko, H; Kasuga, K; Kuwano, R; Miyashita, A; Nishizawa, M; Nozaki, H; Onodera, O; Sisodia, SS; Takahashi, H | 1 |
| Ballegaard, M; Batbayli, M; Erdal, J; Krabbe, K; Lindquist, SG; Nielsen, JE; Schwartz, M; Stokholm, J; Waldemar, G | 1 |
| Song, JS; Yang, SD | 1 |
| Czernik, AJ; Greengard, P; Marshak, DR; Nairn, AC; Oishi, M; Suzuki, T | 1 |
| Demoise, DC; Lee, VM; Merrick, SE | 1 |
| Grundke-Iqbal, I; Iqbal, K; Wang, JZ | 1 |
| Czernik, AJ; Gandy, SE; Greengard, P; Isohara, T; Lim, GS; Nairn, AC; Oishi, M; Suzuki, T | 1 |
| Akiyama, H; Ikeda, K; Kondo, H; McGeer, PL; Mori, H; Nishimura, T; Oda, T; Sahara, N | 1 |
| Biernat, J; Godemann, R; Illenberger, S; Mandelkow, E; Mandelkow, EM; Zheng-Fischhöfer, Q | 1 |
| Ando, K; Greengard, P; Iijima, K; Isohara, T; Kirino, Y; Nairn, AC; Oishi, M; Suzuki, T; Takeda, S | 1 |
| Suzuki, T; Tomita, S | 1 |
| Gordon-Krajcer, W; Ksiezak-Reding, H; Yang, L | 1 |
| Buerger, K; Davies, P; DeBernardis, J; Hampel, H; Kerkman, D; Kohnken, R; Miller, C; Möller, HJ; Shen, J; Zinkowski, R | 1 |
| Morley, SJ; Rulten, SL; Thorpe, JR | 1 |
| Brownlees, J; Grierson, AJ; Kesavapany, S; Lau, KF; McLoughlin, DM; Miller, CC; Standen, CL | 1 |
| Buerger, K; Davies, P; Hampel, H; Kohnken, R; Moeller, HJ; Rapoport, SI; Teipel, SJ; Zinkowski, R | 1 |
| Ando, K; Elliott, JI; Iijima, KI; Kirino, Y; Suzuki, T | 1 |
| Biernat, J; Goedert, M; Gustke, N; Mandelkow, E; Mandelkow, EM; Meyer, HE; Steiner, B | 1 |
5 review(s) available for threonine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Cdk5-p25 as a key element linking amyloid and tau pathologies in Alzheimer's disease: Mechanisms and possible therapeutic interventions.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Calpain; Cyclin-Dependent Kinase 5; Humans; Phosphorylation; Serine; tau Proteins; Threonine | 2022 |
E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Disease Models, Animal; Gliosis; Mice; Mice, Transgenic; Threonine; Transcription Factors | 2022 |
Phosphorylated tau in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction; Humans; Protein Isoforms; tau Proteins; Threonine | 2023 |
A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.
Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amino Acid Substitution; Black or African American; Case-Control Studies; Dementia; Female; Gene Frequency; Humans; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Male; Middle Aged; Polymorphism, Single Nucleotide; Threonine; United States; White People | 2018 |
[Structure and function of proteins interacting with the cytoplasmic domain of APP].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Arginine; Cytoplasm; DNA-Binding Proteins; Humans; Phosphorylation; Protein Sorting Signals; Threonine; Ubiquitin-Activating Enzymes | 1999 |
2 trial(s) available for threonine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cross-Sectional Studies; Dementia; Diagnosis, Differential; Female; Humans; Male; Mental Status Schedule; Middle Aged; Phosphorylation; Sensitivity and Specificity; tau Proteins; Threonine | 2002 |
Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease.
Topics: Age Distribution; Aged; Alzheimer Disease; Biomarkers; Creutzfeldt-Jakob Syndrome; Diagnosis, Differential; Female; Germany; Humans; Male; Middle Aged; Phosphorylation; Prevalence; Reproducibility of Results; Sensitivity and Specificity; Sex Distribution; Statistics as Topic; tau Proteins; Threonine | 2006 |
93 other study(ies) available for threonine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Biomarkers; Disease Progression; Female; Humans; Male; Peptide Fragments; Plaque, Amyloid; tau Proteins; Threonine | 2022 |
Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain-Derived Neurotrophic Factor; Cognition; Cross-Sectional Studies; Female; Humans; Male; Memory Disorders; Middle Aged; Positron-Emission Tomography; tau Proteins; Threonine | 2022 |
Genome-wide association study identifies APOE locus influencing plasma p-tau181 levels.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Genome-Wide Association Study; Humans; tau Proteins; Threonine | 2022 |
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Autopsy; Biomarkers; Humans; Nervous System Diseases; tau Proteins; Threonine | 2022 |
Dissociable contribution of plasma NfL and p-tau181 to cognitive impairment in Parkinson's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Humans; Middle Aged; Parkinson Disease; Prospective Studies; tau Proteins; Threonine | 2022 |
Sex differences in plasma p-tau181 associations with Alzheimer's disease biomarkers, cognitive decline, and clinical progression.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction; Disease Progression; Female; Glucose; Humans; Male; Sex Characteristics; tau Proteins; Threonine | 2022 |
Alzheimer's disease: Ablating single master site abolishes tau hyperphosphorylation.
Topics: Alzheimer Disease; Animals; Humans; Mice; Phosphorylation; tau Proteins; Tauopathies; Threonine | 2022 |
Initial Data and a Clinical Diagnosis Transition for the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration (ALBION) Study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Disease Progression; Humans; tau Proteins; Threonine | 2022 |
Localization, induction, and cellular effects of tau phosphorylated at threonine 217.
Topics: Alzheimer Disease; Animals; Humans; Mice; Neurons; Phosphorylation; tau Proteins; Threonine | 2023 |
Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction; Disease Progression; Female; Humans; Longitudinal Studies; Male; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Phosphorylation; Prospective Studies; tau Proteins; Threonine | 2020 |
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum.
Topics: Alzheimer Disease; Biomarkers; Brain; Disease Progression; Humans; Longitudinal Studies; Phosphorylation; Positron-Emission Tomography; Prospective Studies; tau Proteins; Threonine | 2021 |
O-GlcNAcylation of amyloid-β precursor protein at threonine 576 residue regulates trafficking and processing.
Topics: Acetylglucosamine; Acylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Cell Membrane; Glycosylation; HeLa Cells; Humans; Point Mutation; Protein Processing, Post-Translational; Protein Transport; Threonine; trans-Golgi Network | 2017 |
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Female; Humans; Male; Middle Aged; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; rab GTP-Binding Proteins; Threonine | 2018 |
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Disease Progression; Female; Humans; Male; Middle Aged; Phosphorylation; Psychiatric Status Rating Scales; Serine; Statistics, Nonparametric; tau Proteins; Threonine; Tyrosine | 2018 |
Topics: Adult; Age of Onset; Alzheimer Disease; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Humans; Hydrogen Bonding; Isoleucine; Male; Middle Aged; Models, Molecular; Pedigree; Presenilin-1; Protein Structure, Secondary; Republic of Korea; Sequence Analysis, DNA; Structural Homology, Protein; Threonine | 2018 |
Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line, Tumor; CHO Cells; Cricetulus; HEK293 Cells; Humans; Phosphorylation; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Threonine | 2019 |
The association between biomarkers in cerebrospinal fluid and structural changes in the brain in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Cognitive Dysfunction; Cross-Sectional Studies; Diffusion Tensor Imaging; Disease Progression; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Phosphorylation; Predictive Value of Tests; Sensitivity and Specificity; Severity of Illness Index; tau Proteins; Threonine | 2014 |
The C-terminal threonine of Aβ43 nucleates toxic aggregation via structural and dynamical changes in monomers and protofibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Structure, Secondary; Threonine | 2014 |
Novel presenilin 1 mutation (p.I83T) in Tunisian family with early-onset Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Exons; Female; Genes, Dominant; Genetic Association Studies; Humans; Isoleucine; Male; Middle Aged; Mutation, Missense; Presenilin-1; Protein Structure, Tertiary; Threonine; Tunisia | 2015 |
Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation.
Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Microscopy, Electron, Transmission; Mutation; Peptide Fragments; Protein Structure, Secondary; Threonine; Valine | 2015 |
Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.
Topics: Age Factors; Aging; Alanine; Alzheimer Disease; Animals; Astrocytes; Cognition Disorders; Cytokines; Dendritic Spines; Disease Models, Animal; Encephalitis; Female; Humans; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nerve Tissue Proteins; Pneumothorax; RNA, Untranslated; tau Proteins; Threonine | 2016 |
Alzheimer's Protective Cross-Interaction between Wild-Type and A2T Variants Alters Aβ
Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Humans; Kinetics; Models, Molecular; Molecular Dynamics Simulation; Monte Carlo Method; Mutation; Peptide Fragments; Protein Multimerization; Protein Structure, Secondary; Threonine | 2017 |
Low Florbetapir PET Uptake and Normal Aβ1-42 Cerebrospinal Fluid in an APP Ala713Thr Mutation Carrier.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Brain; Ethylene Glycols; Humans; Male; Middle Aged; Mutation; Peptide Fragments; Positron-Emission Tomography; Threonine | 2017 |
In silico study on the effect of F19T mutation on amyloid-beta peptide (10-35).
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Computer Simulation; Drug Stability; Humans; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Mutation; Peptide Fragments; Phenylalanine; Static Electricity; Threonine | 2008 |
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Butyrates; Cell Line, Transformed; Cognition Disorders; Disease Models, Animal; Enzyme Inhibitors; Humans; Immunoprecipitation; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mutation; Niacinamide; Peptide Fragments; Phosphorylation; Presenilin-1; Sirtuins; tau Proteins; Threonine; Time Factors; Transfection; Tubulin; Vitamin B Complex | 2008 |
Cerebrospinal fluid levels of tau phosphorylated at threonine 181 in patients with Alzheimer's disease and vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Catalytic Domain; Cognition Disorders; Dementia, Vascular; Disease Progression; Female; Humans; Male; Middle Aged; Neurons; Neuropsychological Tests; Phosphorylation; tau Proteins; Threonine | 2008 |
Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Area Under Curve; Biomarkers; Cognition Disorders; Cohort Studies; Diagnostic Imaging; Disease Progression; Female; Humans; Male; Middle Aged; Peptide Fragments; Phosphorylation; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Statistics, Nonparametric; tau Proteins; Threonine | 2009 |
CSF biomarkers in relationship to cognitive profiles in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Apolipoproteins E; Biomarkers; Cognition Disorders; Disability Evaluation; Disease Progression; Female; Humans; Male; Memory Disorders; Mental Processes; Middle Aged; Neuropsychological Tests; Peptide Fragments; Phosphorylation; Severity of Illness Index; tau Proteins; Threonine; Up-Regulation | 2009 |
Altered subcellular distribution of c-Abl in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Analysis of Variance; Case-Control Studies; Female; Hippocampus; Humans; Immunoprecipitation; Male; Microscopy, Confocal; Middle Aged; Neurofilament Proteins; Phosphorylation; Proto-Oncogene Proteins c-abl; Subcellular Fractions; tau Proteins; Threonine; Tyrosine | 2009 |
Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-tau(181P).
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Autopsy; Biomarkers; Brain; Catalytic Domain; Dementia; Diagnosis, Differential; Female; Humans; Male; Neurofibrillary Tangles; Peptide Fragments; Phosphorylation; Plaque, Amyloid; Predictive Value of Tests; Sensitivity and Specificity; tau Proteins; Threonine | 2009 |
Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Mutation; Peptide Fragments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Tyrosine | 2009 |
Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Atrophy; Biomarkers; Disease Progression; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Phosphorylation; Predictive Value of Tests; Sensitivity and Specificity; Severity of Illness Index; tau Proteins; Threonine | 2009 |
Expression of p25, an aberrant cyclin-dependent kinase 5 activator, stimulates basal secretion in PC12 cells.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cloning, Molecular; Disease Models, Animal; Growth Hormone; Humans; Mutation; Neurons; Neurosecretion; Neurotransmitter Agents; PC12 Cells; Phosphorylation; Phosphotransferases; Rats; Threonine; Transfection; Transgenes | 2010 |
A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Binding Sites; Cells, Cultured; ets-Domain Protein Elk-1; Female; Humans; Huntington Disease; Immunohistochemistry; Inclusion Bodies; Lewy Body Disease; Male; Microscopy, Confocal; Middle Aged; Mutagenesis, Site-Directed; Neurodegenerative Diseases; Neurons; Phosphorylation; Rats; Threonine; Transfection | 2010 |
Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Cognition Disorders; Female; Geriatric Assessment; Humans; Male; Neuropsychological Tests; Peptide Fragments; Phosphorylation; Psychiatric Status Rating Scales; Regression Analysis; Surveys and Questionnaires; tau Proteins; Threonine | 2010 |
Cerebrospinal fluid markers for Alzheimer's disease over the lifespan: effects of age and the APOEε4 genotype.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Apolipoprotein E4; Female; Genotype; Humans; Male; Mental Status Schedule; Middle Aged; Peptide Fragments; Phosphorylation; tau Proteins; Threonine; Young Adult | 2010 |
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antigens, Neoplasm; Apolipoproteins E; Cognition Disorders; Cohort Studies; Diagnostic Imaging; Female; Genome-Wide Association Study; Genotype; Humans; Linkage Disequilibrium; Male; Membrane Transport Proteins; Mitochondrial Precursor Protein Import Complex Proteins; Peptide Fragments; Phosphorylation; Polymorphism, Single Nucleotide; tau Proteins; Threonine | 2011 |
Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.
Topics: Age of Onset; Aged; Alzheimer Disease; Amino Acid Substitution; Female; Frontotemporal Lobar Degeneration; Gene Expression; Genetic Predisposition to Disease; Heterozygote; Humans; Intercellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Linkage Disequilibrium; Male; Membrane Proteins; Middle Aged; Mutation; Nerve Tissue Proteins; Polymorphism, Single Nucleotide; Progranulins; Proportional Hazards Models; Risk Assessment; Risk Factors; Serine; Threonine; Time Factors | 2011 |
Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Peptide Fragments; Phosphorylation; tau Proteins; Threonine | 2011 |
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Chromatography, Liquid; Glycosylation; Humans; Molecular Sequence Data; Proteomics; Serine; Tandem Mass Spectrometry; Threonine; Tyrosine | 2011 |
Dysregulated phosphorylation of Ca(2+) /calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcineurin Inhibitors; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Cognitive Dysfunction; Disks Large Homolog 4 Protein; Embryo, Mammalian; Female; Gene Expression Regulation, Enzymologic; Guanylate Kinases; Hippocampus; Humans; Immunosuppressive Agents; Injections, Intraventricular; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Neurons; Peptide Fragments; Phosphorylation; Protein Transport; Tacrolimus; Threonine; Time Factors | 2011 |
Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Brain; Cell Cycle Proteins; Centrosome; Disease Models, Animal; Humans; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitosis; Phosphorylation; Plaque, Amyloid; Protein Processing, Post-Translational; RNA, Small Interfering; Threonine; Transfection | 2011 |
CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Biomarkers; Cognition Disorders; Disease Progression; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Phosphorylation; Predictive Value of Tests; Regression Analysis; Risk Factors; tau Proteins; Threonine | 2002 |
Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231.
Topics: Aged; Alzheimer Disease; Biomarkers; Depressive Disorder; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Female; Geriatric Assessment; Humans; Male; Phosphorylation; tau Proteins; Threonine | 2003 |
Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Female; Humans; Male; Middle Aged; Phosphorylation; tau Proteins; Threonine | 2003 |
Lack of association between the interleukin-1alpha gene C(-889)T polymorphism and Alzheimer's disease in a Chinese population.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Asian People; Cysteine; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Interleukin-1; Male; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Threonine | 2003 |
Apolipoprotein E -491 promoter polymorphism is an independent risk factor for Alzheimer's disease in the Chinese population.
Topics: Aged; Alanine; Alleles; Alzheimer Disease; Apolipoproteins E; Asian People; Case-Control Studies; Chi-Square Distribution; Cohort Studies; Diagnostic and Statistical Manual of Mental Disorders; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Linkage; Genotype; Humans; Linkage Disequilibrium; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Factors; Threonine | 2003 |
Lack of association between the levels of the low-density lipoprotein receptor-related protein (LRP) and either Alzheimer dementia or LRP exon 3 genotype.
Topics: Alzheimer Disease; Blotting, Western; Brain; Brain Chemistry; Cohort Studies; Cysteine; Exons; Genotype; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Polymorphism, Genetic; Threonine | 2003 |
Phosphorylation of tau protein to sites found in Alzheimer's disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry.
Topics: Alzheimer Disease; Brain; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Catalysis; Gas Chromatography-Mass Spectrometry; Humans; Phosphorylation; Recombinant Proteins; Serine; Spectrometry, Mass, Electrospray Ionization; tau Proteins; Threonine | 2003 |
Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anisomycin; Anthracenes; Brain; Cell Line; Cell Line, Tumor; COS Cells; Down-Regulation; Enzyme Inhibitors; Estradiol; Flavonoids; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; Humans; Immunohistochemistry; In Vitro Techniques; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Neurons; Oxidoreductases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Retroviridae; RNA, Small Interfering; Serine; tau Proteins; Temperature; Threonine; Time Factors; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Tyrosine; WW Domain-Containing Oxidoreductase | 2004 |
Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Biomarkers; Brain; Female; Humans; Male; Memory Disorders; Middle Aged; Neurofibrillary Tangles; Peptide Fragments; Phosphorylation; Predictive Value of Tests; Reproducibility of Results; tau Proteins; Threonine | 2004 |
Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene.
Topics: Adult; Age of Onset; Aged; Alanine; Alleles; Alzheimer Disease; Amyloid Precursor Protein Secretases; Apolipoproteins E; Cysteine; Female; Gene Frequency; Glycine; Haplotypes; Humans; Logistic Models; Male; Membrane Glycoproteins; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Threonine | 2004 |
A novel mutation (Thr116Ile) in the presenilin 1 gene in a patient with early-onset Alzheimer's disease.
Topics: Alzheimer Disease; DNA Mutational Analysis; Female; Humans; Isoleucine; Membrane Proteins; Middle Aged; Mutation; Presenilin-1; Threonine | 2004 |
Expression and phosphorylation of delta-CaM kinase II in cultured Alzheimer fibroblasts.
Topics: Aged; Alzheimer Disease; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cells, Cultured; Cognition Disorders; Female; Fibroblasts; Humans; Isoenzymes; Male; Middle Aged; Neuronal Plasticity; Phosphorylation; RNA, Messenger; Signal Transduction; Threonine | 2004 |
Genetic variation in apolipoprotein D and Alzheimer's disease.
Topics: Age of Onset; Aged; Alanine; Alzheimer Disease; Apolipoproteins; Apolipoproteins D; Case-Control Studies; Cysteine; Female; Finland; Gene Frequency; Genetic Variation; Genotype; Glycine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Threonine | 2004 |
Familial Alzheimer disease associated with A713T mutation in APP.
Topics: Alanine; Alzheimer Disease; Cerebral Cortex; DNA Mutational Analysis; Exons; Humans; Immunohistochemistry; Male; Middle Aged; Molecular Sequence Data; Point Mutation; Serum Amyloid A Protein; Threonine | 2004 |
Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Female; Hippocampus; Histones; Humans; Immunohistochemistry; Male; Mitogen-Activated Protein Kinase 1; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Postmortem Changes; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Threonine | 2005 |
Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cysteine; Female; Genetic Predisposition to Disease; Humans; Japan; Male; Methionine; Middle Aged; Multiple System Atrophy; Parkinson Disease; Polymorphism, Genetic; Threonine; Valine | 2005 |
Correlation of cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 with rates of hippocampal atrophy in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Atrophy; Enzyme-Linked Immunosorbent Assay; Female; Functional Laterality; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Phosphorylation; Statistics as Topic; tau Proteins; Threonine | 2005 |
Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Endopeptidases; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Peptide Fragments; Phosphorylation; Presenilin-1; Protein Processing, Post-Translational; Protein Structure, Tertiary; Rabbits; Threonine; Tumor Cells, Cultured | 2005 |
Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amino Acid Motifs; Amino Acid Sequence; Amyloid beta-Peptides; Anisomycin; Cells, Cultured; Chromatography, Affinity; Humans; Immunoprecipitation; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-akt; Serine; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine | 2006 |
GSK-3beta directly phosphorylates and activates MARK2/PAR-1.
Topics: Alzheimer Disease; Binding Sites; Blotting, Western; Brain; Cell Line; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Hybridomas; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Serine; Threonine; Transfection | 2005 |
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.
Topics: Aged, 80 and over; Alzheimer Disease; Catalytic Domain; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Immunoprecipitation; Iodine Isotopes; Kinetics; Male; Phosphoprotein Phosphatases; Phosphorylation; Postmortem Changes; Serine; tau Proteins; Threonine; Time Factors | 2005 |
P70 S6 kinase mediates tau phosphorylation and synthesis.
Topics: Alzheimer Disease; Cell Line, Tumor; Cell-Free System; Enzyme Activation; Humans; Membrane Proteins; Phosphorylation; Protein Biosynthesis; Ribosomal Protein S6 Kinases, 70-kDa; Serine; Threonine; Zinc | 2006 |
Anomalously phosphorylated tau and Abeta fragments in the CSF correlates with cognitive impairment in MCI subjects.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Blotting, Western; Case-Control Studies; Cognition Disorders; Enzyme-Linked Immunosorbent Assay; Female; Humans; Longitudinal Studies; Male; Neuropsychological Tests; Phosphorylation; Serine; tau Proteins; Threonine | 2006 |
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
Topics: Algorithms; Alzheimer Disease; Amino Acid Sequence; Chromatography, Liquid; Humans; Immunoblotting; Immunoprecipitation; Lysine; Mass Spectrometry; Molecular Sequence Data; Nerve Degeneration; Neurofibrillary Tangles; Peptides; Phosphorylation; Proteasome Endopeptidase Complex; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Serine; Solvents; tau Proteins; Threonine; Trypsin; Ubiquitin | 2006 |
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Catalysis; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Humans; Mice; Mice, Knockout; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Threonine; Transfection | 2006 |
Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.
Topics: Active Transport, Cell Nucleus; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Cell Nucleus; Cells, Cultured; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Mice; Mice, Transgenic; Mutation; Nerve Degeneration; Nerve Growth Factor; Nerve Tissue Proteins; Neurons; Nuclear Proteins; PC12 Cells; Phosphorylation; Protein Structure, Tertiary; Protein Transport; Rats; tau Proteins; Threonine | 2006 |
Simultaneous detection of tau phospho-epitopes with haptenylated antibodies.
Topics: Alzheimer Disease; Antibodies, Monoclonal; Antibody Specificity; Epitopes; Humans; Immunohistochemistry; Neocortex; Nerve Tissue Proteins; Phosphorylation; Serine; tau Proteins; Threonine | 2006 |
The Thr354Ile substitution in PSEN1:: disease-causing mutation or polymorphism?
Topics: Alzheimer Disease; Genetic Predisposition to Disease; Heterozygote; Humans; Male; Membrane Proteins; Middle Aged; Mutation; Polymorphism, Genetic; Presenilin-1; Threonine | 2006 |
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Base Sequence; Brain; DNA Primers; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Mutagenesis, Site-Directed; Peptide Fragments; Phosphorylation; Recombinant Proteins; Threonine | 2006 |
Cerebrospinal fluid tau, phospho-tau181 and beta-amyloid1-42 in idiopathic normal pressure hydrocephalus: a discrimination from Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hydrocephalus, Normal Pressure; Male; Middle Aged; Peptide Fragments; Phosphoproteins; Phosphorylation; Sensitivity and Specificity; tau Proteins; Threonine | 2007 |
Amyloid precursor protein cytoplasmic domain with phospho-Thr668 accumulates in Alzheimer's disease and its transgenic models: a role to mediate interaction of Abeta and tau.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cytoplasm; Enzyme-Linked Immunosorbent Assay; Humans; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; tau Proteins; Threonine | 2007 |
Enhanced proteasome-dependent degradation of the CDK inhibitor p27(kip1) in immortalized lymphocytes from Alzheimer's dementia patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding Sites; Calcium Signaling; Calmodulin; Cell Cycle Proteins; Cell Line, Transformed; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Female; Humans; Lymphocyte Activation; Lymphocytes; Male; Nerve Degeneration; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-akt; Signal Transduction; Threonine; Ubiquitination | 2008 |
DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease.
Topics: Alzheimer Disease; Animals; Brain; Cell Line; DNA, Complementary; Down Syndrome; Dyrk Kinases; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Models, Biological; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Serine; tau Proteins; Threonine | 2007 |
Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line; Down Syndrome; Dyrk Kinases; Gene Expression Regulation; Humans; Mice; Mice, Transgenic; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Threonine; Tyrosine | 2008 |
Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
Topics: Aged; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glioma; Humans; Lewy Body Disease; Mice; Middle Aged; Mutation; Neuroblastoma; Phosphorylation; Presenilin-1; Rats; Receptors, Notch; Threonine; Transfection | 2007 |
Atypical early-onset Alzheimer's disease caused by the Iranian APP mutation.
Topics: Alanine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Blood Pressure; DNA Mutational Analysis; Electroencephalography; Family Health; Humans; Iran; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Peptide Fragments; Threonine | 2008 |
Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Brain; Cattle; Glycogen Synthase Kinase 3; Heparin; Microtubules; Molecular Sequence Data; Peptide Mapping; Phosphopeptides; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Serine; Swine; tau Proteins; Threonine; Trypsin | 1995 |
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cell Cycle; Electrophoresis, Gel, Two-Dimensional; G2 Phase; HeLa Cells; Humans; Kinetics; Methionine; Mitosis; Molecular Sequence Data; PC12 Cells; Peptide Mapping; Peptides; Phosphates; Phosphopeptides; Phosphorylation; Threonine | 1994 |
Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A.
Topics: Alzheimer Disease; Amino Acid Sequence; Antibodies; Autoradiography; Blotting, Western; Cells, Cultured; Colchicine; Electrophoresis, Polyacrylamide Gel; Epitopes; Humans; Methionine; Microtubules; Neurons; Nocodazole; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Protein Phosphatase 2; Serine; Sulfur Radioisotopes; tau Proteins; Teratocarcinoma; Threonine; Tumor Cells, Cultured | 1996 |
Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1.
Topics: Alkaline Phosphatase; Alzheimer Disease; Humans; Microtubules; Phosphates; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; tau Proteins; Threonine | 1996 |
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Antibodies; Brain; Cells, Cultured; Cytoplasm; HeLa Cells; Humans; Molecular Sequence Data; PC12 Cells; Phosphorylation; Rats; Serine; Threonine | 1997 |
Variable deposition of amyloid beta-protein (A beta) with the carboxy-terminus that ends at residue valine40 (A beta 40) in the cerebral cortex of patients with Alzheimer's disease: a double-labeling immunohistochemical study with antibodies specific for
Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Antibody Specificity; Cerebral Cortex; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Peptide Fragments; Staining and Labeling; Threonine; Valine | 1997 |
Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Antibodies, Monoclonal; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Cyclic AMP-Dependent Protein Kinases; Epitopes; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Mapping; Phosphopeptides; Phosphorylation; Point Mutation; Protein Structure, Secondary; Recombinant Proteins; Serine; Substrate Specificity; tau Proteins; Threonine | 1998 |
Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Differentiation; Mutation; Nerve Tissue Proteins; Neurons; PC12 Cells; Phosphorylation; Rats; Threonine | 1999 |
Conformation of paired helical filaments blocks dephosphorylation of epitopes shared with fetal tau except Ser199/202 and Ser202/Thr205.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Alzheimer Disease; Amino Acid Sequence; Brain; Epitopes; Female; Fetus; Formates; Humans; Kinetics; Middle Aged; Neuropil Threads; Phosphorylation; Serine; tau Proteins; Threonine | 2000 |
Detection of tau phosphorylated at threonine 231 in cerebrospinal fluid of Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Humans; Mice; Molecular Sequence Data; Phosphorylation; Phosphothreonine; Sensitivity and Specificity; tau Proteins; Threonine | 2000 |
Utilizing the peptidyl-prolyl cis-trans isomerase pin1 as a probe of its phosphorylated target proteins. Examples of binding to nuclear proteins in a human kidney cell line and to tau in Alzheimer's diseased brain.
Topics: Alzheimer Disease; Brain; Cell Line; Cell Nucleus; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Kidney; Male; Middle Aged; Mitosis; Molecular Probes; NIMA-Interacting Peptidylprolyl Isomerase; Nocodazole; Nuclear Proteins; Peptidylprolyl Isomerase; Phosphorylation; Protein Binding; Serine; tau Proteins; Threonine | 2001 |
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; COS Cells; Cricetinae; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinases; Neurofilament Proteins; Phosphorylation; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Threonine; Transfection | 2001 |
Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231.
Topics: Aged; Alzheimer Disease; Disease Progression; Female; Humans; Male; Middle Aged; Phosphorylation; tau Proteins; Threonine | 2001 |
Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amino Acid Motifs; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Binding Sites; Humans; Nerve Tissue Proteins; Nuclear Proteins; Phosphorylation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Threonine; Two-Hybrid System Techniques | 2001 |
The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.
Topics: Alzheimer Disease; Amino Acid Sequence; Brain; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Humans; Microtubules; Molecular Sequence Data; Mutation; Phosphorylation; Proline; Protein Binding; Protein Kinases; Serine; tau Proteins; Threonine | 1992 |