thorium-x has been researched along with Skin-Neoplasms* in 9 studies
9 other study(ies) available for thorium-x and Skin-Neoplasms
Article | Year |
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Initial Safety and Tumor Control Results From a "First-in-Human" Multicenter Prospective Trial Evaluating a Novel Alpha-Emitting Radionuclide for the Treatment of Locally Advanced Recurrent Squamous Cell Carcinomas of the Skin and Head and Neck.
Our purpose was to report the feasibility and safety of diffusing alpha-emitter radiation therapy (DaRT), which entails the interstitial implantation of a novel alpha-emitting brachytherapy source, for the treatment of locally advanced and recurrent squamous cancers of the skin and head and neck.. This prospective first-in-human, multicenter clinical study evaluated 31 lesions in 28 patients. The primary objective was to determine the feasibility and safety of this approach, and the secondary objectives were to evaluate the initial tumor response and local progression-free survival. Eligibility criteria included all patients with biopsy-proven squamous cancers of the skin and head and neck with either primary tumors or recurrent/previously treated disease by either surgery or prior external beam radiation therapy; 13 of 31 lesions (42%) had received prior radiation therapy. Toxicity was evaluated according to the Common Terminology Criteria for Adverse Events version 4.03. Tumor response was assessed at 30 to 45 days at a follow-up visit using the Response Evaluation Criteria in Solid Tumors, version 1.1. Median follow-up time was 6.7 months.. Acute toxicity included mostly local pain and erythema at the implantation site followed by swelling and mild skin ulceration. For pain and grade 2 skin ulcerations, 90% of patients had resolution within 3 to 5 weeks. Complete response to the Ra-224 DaRT treatment was observed in 22 lesions (22/28; 78.6%); 6 lesions (6/28, 21.4%) manifested a partial response (>30% tumor reduction). Among the 22 lesions with a complete response, 5 (22%) developed a subsequent local relapse at the site of DaRT implantation at a median time of 4.9 months (range, 2.43-5.52 months). The 1-year local progression-free survival probability at the implanted site was 44% overall (confidence interval [CI], 20.3%-64.3%) and 60% (95% CI, 28.61%-81.35%) for complete responders. Overall survival rates at 12 months post-DaRT implantation were 75% (95% CI, 46.14%-89.99%) among all patients and 93% (95% CI, 59.08%-98.96%) among complete responders.. Alpha-emitter brachytherapy using DaRT achieved significant tumor responses without grade 3 or higher toxicities observed. Longer follow-up observations and larger studies are underway to validate these findings. Topics: Aged; Aged, 80 and over; Alpha Particles; Brachytherapy; Carcinoma, Squamous Cell; Erythema; Feasibility Studies; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Pain, Procedural; Photography; Pilot Projects; Progression-Free Survival; Prospective Studies; Radium; Safety; Skin Neoplasms; Skin Ulcer; Thorium; Time Factors; Treatment Outcome | 2020 |
Thorium X treatment: multiple basal cell carcinomas within a port-wine stain.
Thorium X is an ionizing radiation treatment that was commonly used by dermatologists in the 1930 s to 1950 s to treat a variety of benign dermatoses and vascular lesions including port-wine stains. By the 1960 s, thorium X was discontinued due to poor clinical results and the carcinogenic potential. We report a 64-year-old man with a history of multiple basal cell carcinomas in a facial port wine stain, which had previously been treated with thorium X. Topics: Carcinoma, Basal Cell; Facial Neoplasms; Humans; Male; Middle Aged; Neoplasms, Radiation-Induced; Port-Wine Stain; Radium; Skin Neoplasms; Thorium | 2009 |
Thorium X and skin cancer: still a problem in the 21st century.
Topics: Alopecia Areata; Carcinoma, Basal Cell; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasms, Radiation-Induced; Radiotherapy; Radium; Scalp; Skin Neoplasms; Thorium | 2007 |
Basal cell carcinoma presenting as a delayed complication of thorium X used for treating a congenital hemangioma.
Topics: Carcinoma, Basal Cell; Facial Neoplasms; Female; Hemangioma; Humans; Middle Aged; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Radium; Skin Neoplasms; Thorium | 1994 |
Thorium X-induced basal-cell carcinoma: a case report.
Topics: Carcinoma, Basal Cell; Humans; Radium; Skin Neoplasms; Thorium | 1961 |
[Treatment of naevus flammeus with thorium X in patients of public health insurance].
Topics: Humans; Insurance; Insurance, Health; Nevus; Nevus, Pigmented; Port-Wine Stain; Radium; Skin Neoplasms; Thorium | 1953 |
Thorium X treatment of skin epithelioma, keratoses, and delayed radiation changes.
Topics: Carcinoma; Humans; Keratosis; Radium; Skin Neoplasms; Thorium | 1951 |
Treatment of haemangiomatous naevi with thorium X.
Topics: Humans; Nevus; Nevus, Pigmented; Radium; Skin Neoplasms; Thorium | 1951 |
[Noticeable clearing up of a pigmented nevus on the lower leg following single application of doramad (thorium X)].
Topics: Humans; Leg; Nevus, Pigmented; Radium; Scleroderma, Localized; Scleroderma, Systemic; Skin Neoplasms; Thorium | 1950 |