thorium-x and Ovarian-Neoplasms

Patients with advanced-stage ovarian cancer face a poor prognosis because of recurrent peritoneal cavity metastases following surgery and chemotherapy. Alpha-emitters may enable the efficient treatment of such disseminated diseases because of their short range and highly energetic radiation. Radium-224 is a candidate α-emitter due to its convenient 3.6-day half-life, with more than 90% of the decay energy originating from α-particles. However, its inherent skeletal accumulation must be overcome to facilitate intraperitoneal delivery of the radiation dose. Therefore,. The antitumor effect of CaCO. Nude athymic mice were inoculated intraperitoneally with human ovarian cancer cells (ES-2) and treated with a single intraperitoneal injection of. Radium-224-labeled CaCO

Topics: Alpha Particles; Animals; Calcium Carbonate; Drug Delivery Systems; Female; Mice; Ovarian Neoplasms; Particle Size; Radiopharmaceuticals; Radiotherapy Dosage; Radium; Thorium