thiram has been researched along with Parkinson Disease in 2 studies
Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.
thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thiram was also found as a good inhibitor of the protective activity of DJ-1 against glycation." | 1.91 | Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease. ( Barouki, R; Birman, S; Coumoul, X; Dairou, J; Galardon, E; Gonis, E; Larigot, L; Laurent, C; Le-Grand, B; Mansuy, D; Mathas, N; Nioche, P; Poncet, G; Sari, MA; Tiouaini, M, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mathas, N | 1 |
| Poncet, G | 1 |
| Laurent, C | 1 |
| Larigot, L | 1 |
| Le-Grand, B | 1 |
| Gonis, E | 1 |
| Birman, S | 1 |
| Galardon, E | 1 |
| Sari, MA | 1 |
| Tiouaini, M | 1 |
| Nioche, P | 1 |
| Barouki, R | 1 |
| Coumoul, X | 1 |
| Mansuy, D | 1 |
| Dairou, J | 1 |
| Farkas, S | 1 |
| Nagy, K | 1 |
| Jia, Z | 1 |
| Harkany, T | 1 |
| Palkovits, M | 1 |
| Donohou, SR | 1 |
| Pike, VW | 1 |
| Halldin, C | 1 |
| Máthé, D | 1 |
| Csiba, L | 1 |
| Gulyás, B | 1 |
2 other studies available for thiram and Parkinson Disease
| Article | Year |
|---|---|
Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease.
Topics: Humans; Neurodegenerative Diseases; Parkinson Disease; Pesticides; Protein Deglycase DJ-1; Thiram | 2023 |
The decrease of dopamine D₂/D₃ receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CB₁ cannabinoid receptors in Parkinson's disease: a preliminary autoradiographic study with the selective dopamine D₂/D₃ antagoni
Topics: Aged; Autoradiography; Case-Control Studies; Caudate Nucleus; Dopamine Antagonists; Female; Humans; | 2012 |