thiourea and Tuberculosis--Pulmonary

thiourea has been researched along with Tuberculosis--Pulmonary* in 13 studies

Other Studies

13 other study(ies) available for thiourea and Tuberculosis--Pulmonary

Article	Year
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorganic & medicinal chemistry, 2022, 01-01, Volume: 53 Tuberculosis (TB) remains a serious public health problem and one of the main concern is the emergence of multidrug-resistant and extensively resistant TB. Hyper-reactive patients develop inflammatory necrotic lung lesions that aggravate the pathology and facilitate transmission of mycobacteria. Treatment of severe TB is a major clinical challenge that has few effective solutions and patients face a poor prognosis, years of treatment and different adverse drug reactions. In this work, fifteen novel and thirty-one unusual thiourea derivatives were synthesized and evaluated in vitro for their antimycobacterial and anti-inflammatory potential and, in silico for ADMET parameters and for structure-activity relationship (SAR). Thioureas derivatives 10, 15, 16, 28 and 29 that had shown low cytotoxicity and high activities were selected for further investigation, after SAR study. These five thioureas derivatives inhibited Mtb H37Rv growth in bacterial culture and in infected macrophages, highlighting thiourea derivative 28 (MIC Topics: Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Severity of Illness Index; Structure-Activity Relationship; Thiourea; Tuberculosis, Pulmonary	2022
[Tuberculostatic active N,N'-diarylthioureas. 1]. Arzneimittel-Forschung, 1969, Volume: 19, Issue:4 Topics: Animals; Antitubercular Agents; Drug Tolerance; Guinea Pigs; Isoniazid; Mice; Mycobacterium tuberculosis; Phenylthiourea; Thiourea; Tuberculosis, Pulmonary	1969
[Trial treatment of pulmonary tuberculosis with a combination of isoniazid and an injectable diphenylthiourea preparation]. Maroc medical, 1967, Volume: 47, Issue:501 Topics: Adolescent; Adult; Aged; BCG Vaccine; Drug Tolerance; Female; Humans; Injections, Intramuscular; Isoniazid; Male; Middle Aged; Morocco; Mycobacterium; Radiography; Statistics as Topic; Thiourea; Tuberculosis, Pulmonary	1967
[STUDY OF AMBULATORY TREATMENT OF PULMONARY TUBERCULOSIS WITH THE COMBINATION OF 1906 CIBA (DPT) AND INH]. Annales des Societes belges de medecine tropicale, de parasitologie, et de mycologie, 1964, Volume: 44 Topics: Drug Therapy; Isoniazid; Phenylthiourea; Thiourea; Toxicology; Tuberculosis; Tuberculosis, Pulmonary	1964
[PIN-POINTING THE FEMALE GENITAL LOCALIZATION IN THE TUBERCULOUS PATIENT AND ITS MEDICAL TREATMENT]. Revista de la Asociacion Medica Argentina, 1963, Volume: 77 Topics: Antitubercular Agents; Cycloserine; Oxytetracycline; Phenazines; Thiourea; Tuberculosis; Tuberculosis, Female Genital; Tuberculosis, Gastrointestinal; Tuberculosis, Hepatic; Tuberculosis, Pulmonary; Tuberculosis, Urogenital; Viomycin	1963
[Therapeutic trial with 4,4-'diiosoamyloxythiocarbanilide in pulmonary tuberculosis]. Schweizerische Zeitschrift fur Tuberkulose und Pneumonologie. Revue suisse de la tuberculose et de pneumonologie. Rivista svizzera della tubercolosi e della pneumonologia, 1961, Volume: 18 Topics: Thiourea; Tuberculosis; Tuberculosis, Pulmonary	1961
[Preliminary report on treatment of pulmonary tuberculosis with Isoxyl]. Hoja tisiologica, 1961, Volume: 21 Topics: Phenylthiourea; Thiourea; Tuberculosis; Tuberculosis, Pulmonary	1961
Results of therapy with thiocarbanidin used with isoniazid or streptomycin. The American review of respiratory disease, 1960, Volume: 81 Topics: Antitubercular Agents; Isoniazid; Streptomycin; Thiourea; Tuberculosis; Tuberculosis, Pulmonary	1960
A clinical evaluation of thiocarbanidin and isoniazid in the treatment of pulmonary tuberculosis. The American review of respiratory disease, 1959, Volume: 80 Topics: Antitubercular Agents; Isoniazid; Thiourea; Tuberculosis; Tuberculosis, Pulmonary	1959
[Use of the preparation ethoxid in clinical pulmonary tuberculosis]. Problemy tuberkuleza, 1959, Volume: 37(8) Topics: Antitubercular Agents; Thiourea; Tuberculosis, Pulmonary	1959
[Thorax diseases in pulmonary tuberculosis and their treatment with mediment]. Die Medizinische, 1955, Aug-20, Issue:33-34 Topics: Chloroform; Disease; Humans; Liniments; Thiourea; Thoracic Diseases; Thorax; Tuberculosis; Tuberculosis, Pulmonary	1955
A comparison of the sensitivity of some methods for determining the activity of thyroid glands. Acta endocrinologica, 1955, Volume: 18, Issue:3 Topics: Anti-Bacterial Agents; Thiouracil; Thiourea; Thyroid Gland; Tuberculosis; Tuberculosis, Pulmonary; Viscera	1955
[Necacyl (benzothiocarbamide), an adjuvant medication for the treatment of pulmonary tuberculosis]. Schweizerische medizinische Wochenschrift, 1951, Jan-27, Volume: 81, Issue:4 Topics: Analgesics; Humans; Thiourea; Tuberculosis; Tuberculosis, Pulmonary	1951