thiourea and Schistosomiasis

Lactate dehydrogenase isoenzyme (LD5) which is associated with anaerobic respiration was inhibited to a certain degree in Biomphalaria alexandrina snails, the intermediate host for Schistosoma mansoni. Urea and thiourea were used as inhibitors. The effect of LD5 inhibition on the mortality rate of infected Biomphalaria alexandrina snails and on the susceptibility of the snails to the trematode infection was also studied.

Topics: Anaerobiosis; Animals; Biomphalaria; Isoenzymes; L-Lactate Dehydrogenase; Schistosomiasis; Thiourea; Urea

It has been found that treatment of mice infected with Schistosoma mansoni with thiosinamine for five days had a significant effect on the formation of normal egg-shells within the ootype of female worms. The protein material, not organized into complete egg-shells, was nevertheless tanned and the surface of these amorphous masses was formed into microspines. Normal egg-shell formation was restored following drug withdrawal. The process of egg-shell formation consists of the integration of the physical moulding of egg-shell precursors derived from the vitelline cells, associated with the chemical process of protein tanning. It is suggested that thiosinamine treatment in vivo results in disruption of egg-shell formation by causing a breakdown in the moulding process and not by the inhibition of protein tanning involving the enzyme polyphenoloxidase. Treatment of worms with the drug under in vitro conditions resulted in a more enhanced effect of egg-shell formation.

Topics: Animals; Female; Mice; Microscopy, Electron; Ovum; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiourea

Topics: Animals; Antigens; Isothiuronium; Mice; Movement; Schistosoma mansoni; Schistosomiasis; Thiourea

Topics: Animals; Anthelmintics; Female; Mice; Ovum; Schistosomiasis; Thiourea

Topics: Africa; Africa, Western; Animals; Communicable Disease Control; Fascioliasis; Humans; Molluscacides; Schistosomiasis; Snails; Solubility; Thiourea; Zinc

Topics: Animals; Communicable Disease Control; Filariasis; Fishes; Food Contamination; Mollusca; Molluscacides; Rivers; Schistosomiasis; Snails; Thiourea; Toxicology; Zinc; Ziram