thiourea and Peptic-Ulcer

Topics: Adenylyl Cyclases; Cimetidine; Clinical Trials as Topic; Enzyme Activation; Female; Gastric Mucosa; Guanidines; Histamine; Humans; Male; Middle Aged; Peptic Ulcer; Phenethylamines; Pyrilamine; Receptors, Histamine; Receptors, Histamine H2; Thiourea

Topics: Clinical Trials as Topic; Humans; Metiamide; Palliative Care; Peptic Ulcer; Placebos; Thiourea; Wound Healing

Topics: Animals; Gastric Juice; Male; Metiamide; Peptic Ulcer; Rats; Secretory Rate; Thiourea

In normal and stressed rats with chronic gastric fistula small doses of metiamide (0.001-0.01 muM/kg) increased and doses of over 20 muM/kg decreased gastric acid secretion. In both these dose ranges of dosage metiamide suppressed the development of stress ulcers, most markedly in doses of 0.005 and 100 muM/kg. Intermediate doses had no such action. Only the anti-ulcer action of large doses of metiamide ran parallel to a reduction in acid secretion. Small doses of metiamide increased gastric secretion, but like larger doses, had a weak adrenergic action.

Topics: Animals; Biogenic Amines; Blood Glucose; Brain; Female; Gastric Juice; Gastric Mucosa; Male; Metiamide; Peptic Ulcer; Rats; Receptors, Drug; Stress, Physiological; Thiourea

The new histamine H2-receptor antagonist, metiamide, was shown to inhibit acid and pepsin secretion in gastric secretion studies performed on patients suffering from peptic ulceration. The new drug was administered intravenously in these experiments, but effective plasma levels could also be produced by oral administration. When symptomatic patients were treated with the drug nearly all experienced marked symptomatic relief, and there was some evidence that ulcer healing occurred during treatment. When the drug was withdrawn symptoms tended to return. No toxic reactions were encountered in this trial. Double-blind studies are now being made in Britain to establish the place metiamide may have in the treatment of duodenal ulceration.

Topics: Depression, Chemical; Female; Gastric Juice; Humans; Male; Metiamide; Peptic Ulcer; Thiourea

Topics: Agranulocytosis; Animals; Dogs; Gastric Juice; Histamine H1 Antagonists; Humans; Imidazoles; Male; Peptic Ulcer; Rats; Secretory Rate; Sulfides; Thiourea

Topics: Animals; Atropine; Cats; Drug Therapy, Combination; Histamine H1 Antagonists; Imidazoles; Peptic Ulcer; Stomach; Sulfides; Thiourea

Topics: Animals; Arrhythmias, Cardiac; Cyclic AMP; Gastric Juice; Gastric Mucosa; Guinea Pigs; Heart; Heart Rate; Histamine; Histamine H1 Antagonists; Humans; Imidazoles; Myocardium; Peptic Ulcer; Rabbits; Receptors, Drug; Sulfides; Thiourea; Vagus Nerve

Topics: Depression, Chemical; Gastric Juice; Histamine H1 Antagonists; Humans; Imidazoles; Male; Peptic Ulcer; Receptors, Drug; Secretory Rate; Stomach; Sulfides; Thiourea; Vagus Nerve

Topics: Agranulocytosis; Depression, Chemical; Duodenal Ulcer; Gastric Juice; Histamine H1 Antagonists; Humans; Imidazoles; Peptic Ulcer; Receptors, Drug; Sulfides; Thiourea

Acute, subacute and chronic toxicity of TURISYNCHRON and its zinc complex (SUISYNCHRON) was tested in mice, rats and dogs. The acute toxicity of SUISYNCHRON was lower than that of TURISYNCHRON in mice and rats. Ulcerative lesions in the duodenum produced by high doses of SUISYNCHRON were quantitatively less pronounced than those produced by similar doses of TURISYNCHRON. Subacute toxicity testing in rats showed that neither preparation had any toxic effect on haematological, clinical chemical or histological criteria in the dosages selected. Chronic toxicity testing of TURISYNCHRON in dogs did not reveal any evidence of toxic damage.

Topics: Acute Disease; Administration, Oral; Animals; Atropine; Body Weight; Chlorpromazine; Chronic Disease; Duodenal Diseases; Female; Injections, Subcutaneous; Lethal Dose 50; Maternal-Fetal Exchange; Methallibure; Mice; Organ Size; Papaverine; Peptic Ulcer; Poisoning; Pregnancy; Rats; Sex Factors; Structure-Activity Relationship; Thiourea; Zinc

Topics: Administration, Oral; Animals; Costs and Cost Analysis; Depression, Chemical; Drug Evaluation, Preclinical; Gastric Juice; Humans; Imidazoles; Pentagastrin; Peptic Ulcer; Receptors, Drug; Secretory Rate; Sulfides; Thiourea