thiourea and Peptic-Ulcer

thiourea has been researched along with Peptic-Ulcer* in 12 studies

Trials

2 trial(s) available for thiourea and Peptic-Ulcer

ArticleYear
Human gastric mucosal adenylate cyclase: activation by histamine-H2-receptor stimulation and inhibition by cimetidine in vitro and in peptic ulcer patients.
    European journal of clinical pharmacology, 1979, Apr-17, Volume: 15, Issue:3

    Topics: Adenylyl Cyclases; Cimetidine; Clinical Trials as Topic; Enzyme Activation; Female; Gastric Mucosa; Guanidines; Histamine; Humans; Male; Middle Aged; Peptic Ulcer; Phenethylamines; Pyrilamine; Receptors, Histamine; Receptors, Histamine H2; Thiourea

1979
Proceedings: Should peptic ulcer treatment relieve symptoms or heal ulcers?
    Gut, 1976, Volume: 17, Issue:5

    Topics: Clinical Trials as Topic; Humans; Metiamide; Palliative Care; Peptic Ulcer; Placebos; Thiourea; Wound Healing

1976

Other Studies

10 other study(ies) available for thiourea and Peptic-Ulcer

ArticleYear
[Effect of metiamide, an antagonits of H-2 phistamine receptor, on the development of experimental peptic ulcer in rats].
    Folia medica Cracoviensia, 1977, Volume: 19, Issue:3

    Topics: Animals; Gastric Juice; Male; Metiamide; Peptic Ulcer; Rats; Secretory Rate; Thiourea

1977
Effect of metiamide, a histamine H2 - receptor antagonist, on the development of gastric stress ulcers and acid secretion.
    European journal of pharmacology, 1976, Volume: 36, Issue:1

    In normal and stressed rats with chronic gastric fistula small doses of metiamide (0.001-0.01 muM/kg) increased and doses of over 20 muM/kg decreased gastric acid secretion. In both these dose ranges of dosage metiamide suppressed the development of stress ulcers, most markedly in doses of 0.005 and 100 muM/kg. Intermediate doses had no such action. Only the anti-ulcer action of large doses of metiamide ran parallel to a reduction in acid secretion. Small doses of metiamide increased gastric secretion, but like larger doses, had a weak adrenergic action.

    Topics: Animals; Biogenic Amines; Blood Glucose; Brain; Female; Gastric Juice; Gastric Mucosa; Male; Metiamide; Peptic Ulcer; Rats; Receptors, Drug; Stress, Physiological; Thiourea

1976
Clinical experience with metiamide.
    Federation proceedings, 1976, Volume: 35, Issue:8

    The new histamine H2-receptor antagonist, metiamide, was shown to inhibit acid and pepsin secretion in gastric secretion studies performed on patients suffering from peptic ulceration. The new drug was administered intravenously in these experiments, but effective plasma levels could also be produced by oral administration. When symptomatic patients were treated with the drug nearly all experienced marked symptomatic relief, and there was some evidence that ulcer healing occurred during treatment. When the drug was withdrawn symptoms tended to return. No toxic reactions were encountered in this trial. Double-blind studies are now being made in Britain to establish the place metiamide may have in the treatment of duodenal ulceration.

    Topics: Depression, Chemical; Female; Gastric Juice; Humans; Male; Metiamide; Peptic Ulcer; Thiourea

1976
Editorial: Antihistamines and gastric acid secretion.
    Canadian Medical Association journal, 1975, Jan-25, Volume: 112, Issue:2

    Topics: Agranulocytosis; Animals; Dogs; Gastric Juice; Histamine H1 Antagonists; Humans; Imidazoles; Male; Peptic Ulcer; Rats; Secretory Rate; Sulfides; Thiourea

1975
Proceedings: The interaction of cholinergic and histaminic blockades on the partieta cell: therapeutic possibilities.
    The British journal of surgery, 1975, Volume: 62, Issue:2

    Topics: Animals; Atropine; Cats; Drug Therapy, Combination; Histamine H1 Antagonists; Imidazoles; Peptic Ulcer; Stomach; Sulfides; Thiourea

1975
Editorial: New antagonists excite an old histamine prospector.
    The New England journal of medicine, 1974, Mar-28, Volume: 290, Issue:13

    Topics: Animals; Arrhythmias, Cardiac; Cyclic AMP; Gastric Juice; Gastric Mucosa; Guinea Pigs; Heart; Heart Rate; Histamine; Histamine H1 Antagonists; Humans; Imidazoles; Myocardium; Peptic Ulcer; Rabbits; Receptors, Drug; Sulfides; Thiourea; Vagus Nerve

1974
Proceedings: Effect of H2-receptor blockade on vagally induced gastric secretion and gastric emptying in man.
    Gut, 1974, Volume: 15, Issue:4

    Topics: Depression, Chemical; Gastric Juice; Histamine H1 Antagonists; Humans; Imidazoles; Male; Peptic Ulcer; Receptors, Drug; Secretory Rate; Stomach; Sulfides; Thiourea; Vagus Nerve

1974
Editorial: Unrefined antihistamine lode.
    The New England journal of medicine, 1974, Aug-22, Volume: 291, Issue:8

    Topics: Agranulocytosis; Depression, Chemical; Duodenal Ulcer; Gastric Juice; Histamine H1 Antagonists; Humans; Imidazoles; Peptic Ulcer; Receptors, Drug; Sulfides; Thiourea

1974
[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHROM. 2. Toxicologic findings].
    Archiv fur experimentelle Veterinarmedizin, 1974, Volume: 28, Issue:5

    Acute, subacute and chronic toxicity of TURISYNCHRON and its zinc complex (SUISYNCHRON) was tested in mice, rats and dogs. The acute toxicity of SUISYNCHRON was lower than that of TURISYNCHRON in mice and rats. Ulcerative lesions in the duodenum produced by high doses of SUISYNCHRON were quantitatively less pronounced than those produced by similar doses of TURISYNCHRON. Subacute toxicity testing in rats showed that neither preparation had any toxic effect on haematological, clinical chemical or histological criteria in the dosages selected. Chronic toxicity testing of TURISYNCHRON in dogs did not reveal any evidence of toxic damage.

    Topics: Acute Disease; Administration, Oral; Animals; Atropine; Body Weight; Chlorpromazine; Chronic Disease; Duodenal Diseases; Female; Injections, Subcutaneous; Lethal Dose 50; Maternal-Fetal Exchange; Methallibure; Mice; Organ Size; Papaverine; Peptic Ulcer; Poisoning; Pregnancy; Rats; Sex Factors; Structure-Activity Relationship; Thiourea; Zinc

1974
Control of gastric acid secretion by histamine H2-receptor antagonists; a pharmacological dream come true.
    Australian and New Zealand journal of medicine, 1974, Volume: 4, Issue:5

    Topics: Administration, Oral; Animals; Costs and Cost Analysis; Depression, Chemical; Drug Evaluation, Preclinical; Gastric Juice; Humans; Imidazoles; Pentagastrin; Peptic Ulcer; Receptors, Drug; Secretory Rate; Sulfides; Thiourea

1974