thiourea and Muscular-Diseases

Large conductance calcium-activated potassium (BK) channels play a crucial role in the repolarization and after-hyperpolarization phases of the cell membrane. The channel openers are also used in treatment of some diseases, including hypo/hyperkalemic periodic paralysis. However, little is known about the effects of BK channels and the channel activators on membrane potentials in skeletal muscle. In addition, the effects of reactive oxygen species (ROS) on BK channels in skeletal muscle are also unknown. Therefore, the aim of this study was to determine the effects of BK channel openers and ROS on membrane potentials in skeletal muscle fibers. For this purpose, resting membrane potentials and action potentials (AP) of frog gastrocnemius muscles were recorded in the presence of commonly used BK channel openers NS1619 and NS11021, H

Topics: Action Potentials; Animals; Benzimidazoles; Humans; Hydrogen Peroxide; Large-Conductance Calcium-Activated Potassium Channels; Membrane Potentials; Muscle Fibers, Skeletal; Muscular Diseases; Reactive Oxygen Species; Tetrazoles; Thiourea; Xenopus laevis

Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Bungarotoxins; Choline; Hemicholinium 3; Male; Muscular Diseases; Neuromuscular Junction; Rats; Rats, Inbred Strains; Thiourea