thiourea and Morphine-Dependence

thiourea has been researched along with Morphine-Dependence* in 2 studies

Other Studies

2 other study(ies) available for thiourea and Morphine-Dependence

Article	Year
[Effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2009, Volume: 38, Issue:6 To investigate the effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference (CPP) in rats.. The persistence, extinction and reinstatement of morphine-induced CPP were established.In clobenpropit group three different doses of clobenpropit (2, 5 and 10 microg/rat, i.c.v.) were administered 15 min after morphine (1 mg/kg, i.p.) was injected. In histidine group histidine (100, 200, 500 mg/kg) was given 1 h prior to morphine treatment (1 mg/kg i.p).. The CPP was reinstated by priming injection of 1 mg/kg morphine. Clobenpropit (5, 10 microg/rat) significantly inhabited the reinstatement by a priming dose of morphine-induced CPP compared with the morphine control group; histidine (100, 200, 500 mg/kg) significantly inhibited the reinstatement in a dose-dependent manner.. Clobenpropit and histidine inhibit the revival of morphine-induced CPP in a dose dependent manner, indicating that endogenous histamine may inhibit relapse of morphine to some extent. Topics: Animals; Conditioning, Operant; Histidine; Imidazoles; Male; Morphine Dependence; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Substance Withdrawal Syndrome; Thiourea	2009
Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice. Behavioural brain research, 2006, Jan-06, Volume: 166, Issue:1 The effects of intracerebroventricular (i.c.v.) administration of ultra low doses (ULDs) of histamine, clobenpropit and pyrilamine are studied on morphine state-dependent (STD) memory in mice. Although pre-test administration of different doses of histamine and clobenpropit showed no effect on impairment of memory induced by pre-training morphine, when the above drugs were co-administered with morphine, they inhibited the restoration of memory by morphine. These effects were opposite to microgram doses of the same drugs. Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Histamine; Histamine Agents; Imidazoles; Injections, Intraventricular; Male; Memory; Mice; Morphine; Morphine Dependence; Pyrilamine; Reaction Time; Thiourea	2006

Article

Year

[Effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2009, Volume: 38, Issue:6

To investigate the effects of clobenpropit and histidine on reinstatement of morphine-induced conditioned place preference (CPP) in rats.. The persistence, extinction and reinstatement of morphine-induced CPP were established.In clobenpropit group three different doses of clobenpropit (2, 5 and 10 microg/rat, i.c.v.) were administered 15 min after morphine (1 mg/kg, i.p.) was injected. In histidine group histidine (100, 200, 500 mg/kg) was given 1 h prior to morphine treatment (1 mg/kg i.p).. The CPP was reinstated by priming injection of 1 mg/kg morphine. Clobenpropit (5, 10 microg/rat) significantly inhabited the reinstatement by a priming dose of morphine-induced CPP compared with the morphine control group; histidine (100, 200, 500 mg/kg) significantly inhibited the reinstatement in a dose-dependent manner.. Clobenpropit and histidine inhibit the revival of morphine-induced CPP in a dose dependent manner, indicating that endogenous histamine may inhibit relapse of morphine to some extent.

Topics: Animals; Conditioning, Operant; Histidine; Imidazoles; Male; Morphine Dependence; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Substance Withdrawal Syndrome; Thiourea

2009

Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice.

Behavioural brain research, 2006, Jan-06, Volume: 166, Issue:1

The effects of intracerebroventricular (i.c.v.) administration of ultra low doses (ULDs) of histamine, clobenpropit and pyrilamine are studied on morphine state-dependent (STD) memory in mice. Although pre-test administration of different doses of histamine and clobenpropit showed no effect on impairment of memory induced by pre-training morphine, when the above drugs were co-administered with morphine, they inhibited the restoration of memory by morphine. These effects were opposite to microgram doses of the same drugs.

Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Histamine; Histamine Agents; Imidazoles; Injections, Intraventricular; Male; Memory; Mice; Morphine; Morphine Dependence; Pyrilamine; Reaction Time; Thiourea

2006